Effects of PEG molecular weight on its interaction with albumin

The fluorescence property of bovine serum albumin was investigated in the presence of PEGs of different molecular weights. Based on our results, we propose that PEGs of different molecular weights bind to albumin in the p H 7.4 aqueous solution, but only when the polymer size is larger than the protein size, one polymer chain may bind to multiple proteins and cause the proteins to aggregate.     

药物递送中的高分子原理

药物递送正在逐渐成熟为一门工程科学,主要根据药理学的要求,利用材料科学的基本原理来进行递送体系设计和研究.高分子是药用材料的主要类别,本文以药物一高分子固体分散体和高分子药物为例,讨论了高分子科学中的基本原理,尤其是结构与性能关系,是如何在药物递送研究和设计中得以体现的.另一方面,药物递送领域的发展也对高分子科学提出了...     

A method to accelerate the gelation of disulfide-crosslinked hydrogels

A glutathione-disulfide-ended poly(ethylene glycol)(GSSG-PEG-GSSG) was designed. It is a much more efficient accelerator than glutathione disulfide(GSSG) for the gelation of an 8arm-PEG-SH polymer solution, and the gelation time can be tuned from hours to minutes at the physiological p H and temperature. A mechanism was proposed to explain the different behaviors of the GSSG and GSSG-PEG-GSSG gelation systems. Due to the ever-going thiol-disulfide exchange reaction, the thiol-disulfide hydrogels also showed interesting swelling behavior.