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MicroRNAs是一类内源性非编码小RNA分子,可调控靶基因的表达。特异性microRNAs的失调在诸如癌症、心血管疾病、免疫疾病、神经退行性疾病和皮肤疾病等的发展过程中起着关键作用,常作为疾病早期诊断和预后的生物标志物。电化学生物传感器由于其灵敏、快速、成本低等优势,已经成为传统microRNAs检测方法的一种很有前途的替代方法。本文综述了基于microRNA电化学生物传感器检测乳腺癌的研究进展,并对其所构建的电化学生物传感器的检测方法进行了分析探讨。 相似文献
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为调查A河、B河下游水体的水质现状,于2014年丰水期(8月)和枯水期(12月),选取A、B河下游各8个采样点,对水体的溶解氧、氨氮等6项理化指标,以及Hg、Pb等7项重金属指标进行检测,采用单项参数评价法和综合水质标识指数法对2条河流的水质现状进行分析及评价,并采用对数型幂函数普适指数公式对水体的富营养程度进行评价。结果发现,A、B河下游水质以劣V类为主,水体中各类重金属不超标,主要超标污染物为总氮、总磷、氨氮等。A河水质好于B河,2条河流丰水期水质好于枯水期。A、B河下游水体处于重富和极富营养化状态,应加强整治2条河流流域的农业面污染源,降低河流的富营养化风险。 相似文献
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我们发展了一种简易的、无光刻法制备Bi2Sr2CaCu2O8+x单晶内禀结的新型工艺,制备过程简单,重复性好,成功率高,结面积在20μm×20μm~80μm×80μm之间.同时,我们测量了内禀结的直流I~V特性,得到了具有多路电阻分支的内禀约瑟夫逊直流I~V特性曲线 相似文献
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Nafion solution as a binder,the Gr/CeO2 /Nafion/GCE modified electrode was prepared based on graphene (Gr)-nano cerium oxide (CeO2 )composite materials. The electrochemical behavior of Pb(II)on the modified electrode was investigated using differential pulse anodic stripping voltammetry (DPASV). Subsequently,a determination method for Pb(II)was established. The concentrations and ratio of composite materials,buffer solution pH,modification amount,enrichment potential and time were optimized. Under the optimal conditions ,the peak current of Gr/CeO2 /Nafion/GCE showed good linearity in the range of 0.24-48.31 μµmol/L of Pb(II),and the detection limit was 4.3 nmol/L. Interference experiments showed that the other common anions and cations in water samples caused little interference to Pb(II)detection. Furthermore,the interference of Cu(II)within 10 times is acceptable. The modified electrode was used to the detection of Pb(II) in four complex water samples,and the recovery rates of the spiked assays were from 89.5% to 107.7%. © 2023, Youke Publishing Co.,Ltd. All rights reserved. 相似文献
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