Synthesis,Crystal Structure and Antitumor Activity of a Novel Zn(Ⅱ) Complex with 2-(Nicotinoyloxy)acetic Acid Ligand

A novel Zn(Ⅱ) complex, [ZnL_2(H_2O)_4]·H_2O(1, HL = 2-(nicotinoyloxy)acetic acid), was synthesized using Zn(OAc)_2·2H_2O and 2-(nicotinoyloxy)acetic acid as raw materials. Its structure has been elucidated by elemental analysis, IR and single-crystal X-ray diffraction. The structural analysis revealed that complex 1 crystallizes in triclinic, space group P1 and the Zn(Ⅱ) atom is six-coordinated with two N atoms from two different 2-(nicotinoyloxy)acetate anion ligands and four O atoms from coordinated water molecules. Complex 1 forms a 3D network structure by O–H···O hydrogen bonds. The antitumor activities of 2-(nicotinoyloxy)acetic acid ligand and its Zn(Ⅱ) complex were evaluated against human lung adenocarcinoma A549 cells, human hepatoma SMMC-7721 cells and human colon carcinoma Wi Dr cells.     

高效液相色谱-电雾式检测器法同时检测食品中8种人工甜味剂的应用

采用高效液相色谱-电雾式检测器（HPLC-CAD）建立了同时测定食品中8种人工甜味剂的方法。以5 mmol/L甲酸铵和乙腈为流动相进行梯度洗脱,CAD检测器直接检测,外标法定量。研究结果表明,安赛蜜、糖精钠、甜蜜素、三氯蔗糖、阿斯巴甜、阿力甜、爱德万甜和纽甜在相应线性范围内线性关系良好（相关系数R2>0.999）,检出限为5～30μg/L,定量限为20～150μg/L,3个浓度水平的加标回收率在88.5%～102.8%之间,相对标准偏差为0.85%～2.16%。该方法简单、快速、灵敏度高和重复性好,可用于不同食品中人工甜味剂的有效检测研究。