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In an effort to find highly efficient ligands for hepatic asialoglycoprotein receptor(ASGPR),four cluster galac-tosides with different scaffolds were synthesized in this paper.The affinity of these compounds for ASGPR wasanalyzed by binding study in vitro.The results showed that trivalent cluster galactosides behaved better than diva-lent analogues and the cluster galactosides with aryl groups on their scaffolds presented better binding affinity thanthose with aliphatic chain scaffolds. 相似文献
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