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QSAR Studies on 7-Substituted Fluoroquinolones 总被引:1,自引:0,他引:1
1 INTRODUCTION Fluoroquionlones are potent antibacterials with a broad spectrum of activities against gram-positive and gram-negative organisims and mycobacteria by inhibiting bacterial topoisomerase II(DNA gyra- se)[1].These compounds have been successfully used in clinic for a decade and its market has risen in recent years only a little less than that of penicillins and macrolides[2]. The fluoroquinolones constitute a class of extremely potent and orally active broad spectrum antibact… 相似文献
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