分子印迹聚合物在核苷类药物分离分析中的应用

核苷类药物在新型冠状病毒肺炎（COVID-19）、艾滋病及肝炎等病毒性疾病治疗方面效果显著,应用广泛,其准确定量具有重要意义。近年来,基于分子印迹技术合成的分子印迹聚合物（MIPs）备受关注。MIPs可模拟酶与底物或抗体与抗原之间的相互作用,对目标物进行高选择性识别。将MIPs应用于核苷类药物分离分析过程,可显著提高选择性和检测灵敏度。本文对近5年MIPs在核苷类药物样品前处理（固相萃取、固相微萃取等）、色谱分离及传感分析等检测中的应用进行综述,总结了检测过程中面临的挑战,并对其应用前景进行了展望。     

碳点在抗生素分析检测中的应用

抗生素的过度使用对环境造成了极大破坏,对其进行监测控制刻不容缓.常用的分析检测技术,如高效液相色谱(HPLC)、气相色谱(GC)、高效液相色谱-串联质谱(HPLC-MS/MS)等具有高效快速、重现性好、可自动化操作等优点.但对环境样品中抗生素的检测存在样品前处理过程繁琐、检测灵敏度低、实验成本高等问题.结合现有的检测技...     

Advances in chromatographic analysis of ginsenosidesEI北大核心CSCD

Ginsenosides possess pharmacological activities such as anti-aging，cardiovascular protection，and improving immunity. However，the detection and analysis of ginsenosides commonly suffer from the problem of low sensitivity owing to the complex matrix and low content of ginsenosides. Chromatographic technology was often used to detect ginsenosides owing to the advantages of high accuracy，high sensitivity，good reproducibility and low sample consumption，etc. In this review，the application of chromatographic analysis technologies in ginsenosides detection was summarized. First of all，accuracy of test results for the ginsenosides can be effectively improved by using high performance liquid chromatography（HPLC）combined with various detectors. Secondly，the combination of HPLC with mass spectrometry can be utilized for qualitative and quantitative analysis of ginsenosides， as well as other fields， such as metabonomics， pharmacokinetics， intestinal microorganisms and quality control. Moreover，the application of gas chromatography in analysis of ginsenosides was reviewed. Briefly，with the continuous development of chromatographic technology，the degree of accuracy for ginsenosides detection was effectively improved，which is beneficial to realize the effective analysis of ginsenosides. © 2023, Youke Publishing Co., Ltd. All rights reserved.