青蒿素的免疫抑制作用

青蒿素是由中草药黄花蒿(Artemisia annua Linn)中提纯的倍半萜内酯类低毒、高效抗疟药~([1-4])。本文报道了其水溶性衍生物,青蒿素琥珀酸酯钠(简称QHS)对体外小鼠胸腺细胞及部分白血病人外周血细胞~3H-TdR自动掺入以及分裂原刺激下小鼠脾细胞与正常人外周血淋巴细胞~3H-TdR掺入的显著抑制及抑制作用的特点,并讨论了QHS抑制淋巴细胞DNA合成的机理。本文还报道了QHS在体内对小鼠抗体细胞介导的红细胞溶血作用的影响,并对体内外的不同效应作了初步探讨。     

IMMUNOSUPPRESSIVE ACTION OF QINGHAOSU

Qinghaosu (青蒿素), isolated and purified from the Chinese herb Artemisia annua Linn(黄花蒿), and identified as a sesquiterpene with a peroxide bridge and lactone structure,is a highly potent and non-toxic new antimalaria drug. This paper reports the immunosup-pressive action of its water soluble derivative (hemisuccinate Na, QHS). The remarkable sup-pression by QHS of the in vitro ~3HTdR incorporation by mitogen-stimulated mouse spleencells and human peripheral lymphocytes, as well as the spontaneous incorporation by mousethymocytes and blood cells from some leukemia patients is presented and its characteristics aredescribed. The in vivo effect as shown by quantitative PFC is studied and the differencebetween the present in vitro and in vivo effects is investigated. The possible mechanism ofinhibition and discrepancy in effects are discussed.