含1,2,4-三唑杂环的新型Strobilurins衍生物的合成及杀菌活性

为了寻找新的高活性先导化合物, 设计合成了14个未见文献报道的Strobilurins类衍生物, 结构经MS, ¹H NMR, 元素分析确认. 并用X-ray单晶衍射测定了(E)-3-甲氧基-2-[(5-甲基-4-邻溴代苯亚甲基亚胺基-1,2,4-三唑)-3-硫亚甲基]-苯基丙烯酸甲酯(5i)的晶体结构, 证实了分子中的两个C＝C均为E-式构型. 初步生物活性测试结果表明, 在实验浓度下部分化合物具有一定的杀菌活性.     

LAMOST medium-resolution spectroscopic survey of binarity and exotic star (LAMOST-MRS-B): Observation strategy and target selection

LAMOST-MRS-B is one of the sub-surveys of LAMOST medium-resolution ($R\sim7500$) spectroscopic survey. It aims at studying the statistical properties (e.g., binary fraction, orbital period distribution, mass ratio distribution) of binary stars and exotic stars. We intend to observe about 30000 stars ($10 {\rm mag}\leq G < 14.5$ mag) with at least 10 visits in five years. We first planned to observe 25 plates around the galactic plane in 2018. Then the plates were reduced to 12 in 2019 because of the limitation of observation. At the same time, two new plates located at the high galactic latitude were added to explore binary properties influenced by the different environments. In this survey project, we set the identified exotic and low-metallicity stars with the highest observation priorities. For the rest of the selected stars, we gave the higher priority to the relatively brighter stars in order to obtain high quality spectra as many as possible. Spectra of 49129 stars have been obtained in LAMOST-MRS-B field and released in DR8, of which 28828 and 3375 stars have been visited more than twice and ten times with $\rm SNR \geq 10$, respectively. Most of the sources are B-, A-, and F-type stars with $\rm -0.6< [Fe/H] < 0.4 $ dex. We also obtain 347 identified variable and exotic stars and about 250 stars with $\rm [Fe/H] <-1$ dex. We measure radial velocities (RVs) by using 892233 spectra of the stars. The uncertainties of RV achieve about $1$ ${\rm km \cdot s^{-1}}$and $10$ ${\rm km \cdot s^{-1}}$ for 95% of late- and early-type stars, respectively. The datasets presented in this paper are available at http://www.doi.org/10.57760/sciencedb.j00113.00035.