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The rapid development of internet technology has made the access to knowledge more convenient and diverse, which is both an opportunity and a challenge for traditional teaching methods. By analyzing and comparing the characteristics of four advanced teaching methods and techniques, and addressing the specific curriculum features and students' situation, a new mixed teaching model was constructed by Traditional Classroom Teaching Model (TCTM), Small Private Online Course (SPOC) and Flipping Classroom Model (FCM). The proportion of the three teaching methods was about 50%:35%:15%, respectively. By striving to combine their strengths and develop students' learning and reasoning ability gradually, the proposed mode achieved a satisfactory teaching effect. 相似文献
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有机锡化合物能够抑制蛋白酶体的类糜蛋白酶活性(CT),导致细胞死亡,但是其与蛋白酶体的相互作用形式并不清楚.本文测定了丁基锡化合物和苯基锡化合物对蛋白酶体CT活性的IC50值,探讨了有机锡化合物对蛋白酶体CT活性的抑制作用形式.研究表明,对蛋白酶体CT活性,本文研究的一取代或二取代有机锡是弱的、可逆抑制剂,而三丁基锡、三苯基锡是强的、不可逆抑制剂.计算机分子对接分析表明,对于可逆抑制CT活性的有机锡化合物,其预测抑制常数与实测IC50值有良好的线性相关性.三丁基锡和三苯基锡上的Sn原子可能与β5亚基上的Thr1Oγ形成共价配位键,从而不可逆抑制CT活性.总之,本文建立的计算机分子对接模型很好地解释了有机锡化合物与蛋白酶体β5亚基的相互作用形式,这也将有助于了解类似金属化合物与蛋白酶体的相互作用机制. 相似文献
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以聚乙二醇单甲醚-聚乳酸-乙醇酸共聚物(m PEG-PLGA)为载体材料,制备同时载带硫酸长春新碱(VCR)和与之具有协同抗肿瘤作用的姜黄素(Cur)的m PEG-PLGA纳米粒(VCR/Cur-m PEG-PLGA-NP)。建立了以等吸收双波长紫外分光光度法同时测定纳米粒中VCR和Cur含量的方法,研究显示,VCR测定波长296.5nm,等吸收波长462nm;Cur测定波长414nm;VCR在4.0—36.0μg.mL-1范围内,浓度C与差值吸光度ΔA呈良好线性相关;Cur在0.5—8.0μg.mL-1范围内,浓度C与吸光度A具有良好的线性关系。该方法简便迅速,结果准确可靠,适用于VCR/Cur-m PEG-PLGA-NP中药物含量的同时测定。 相似文献
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甲壳素和壳聚糖是可再生的大分子生物质资源.由于分子内和分子间的强烈氢键作用,甲壳素和壳聚糖不能溶解在水或常规有机溶剂中,这极大地限制了其在诸多领域中的应用.离子液体作为一种新型绿色溶剂,对甲壳素和壳聚糖具有优良的溶解作用.本文综述了离子液体对甲壳素和壳聚糖的溶解性能和溶解机理,概述了均相溶液体系中纤维、膜、凝胶等材料的制备以及酰化、接枝共聚、交联、降解、希夫碱化等多种衍生化反应,总结了离子液体在甲壳素和壳聚糖化学研究中面临的挑战并对其进行了展望. 相似文献
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Effect of B-Site Ordering on the Magnetic Order in Multifunctional La_2NiMnO_6 Double Perovskite
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To obtain various Ni/Mn orderings, we use a low-temperature synthesized method to modulate the Ni/Mn ordering of the ferromagnetic-ferroelastic La2NiMnO6 compound, and the Ni/Mn ordering is estimated by the low-temperature saturation magnetism.The microstructures, crystal structures and magnetic properties are investigated, and the Landau theory are used to describe the form and magnitude of the coupling effects between Ni/Mn ordering and magnetic order parameters.It is pre... 相似文献