THE EFFECTS OF PERFUSION OF LATERAL VENTRICLE WITH CaCl_2 ON THE FEBRILE RESPONSE AND cAMP CONTENT IN PLASMA AND CEREBROSPINAL FLUID DURING LP-INDUCED FEVER

Artificial cerebrospinal fluid (c.s.f.) containing 40 mmol/L excess calcium was perfus-ed through the lateral ventricles of New Zealand white rabbits in order to reduce the Na~+/Ca~(++) ratio in the brain and the effects on both the febrile response and adenosine cyclic mo-nophosphate (cAMP) concentration in plasma and c.s.f, during leucocytic pyrogen (LP)-induced fever were observed. The results showed that cAMP concentration in c.s.f, increas-ed significantly during LP-induced fever while the cAMP level in Plasma remained unchang-ed, and the perfusion of artificial c.s,f, containing 40 mmol/L excess calcium can signif-icantly inhibit not only the febrile response but also the increase in c.s.f, cAMP level,while there appears no effect on plasma cAMP concentration, thus demonstrating that theincrease of Na~+/Ca~(++) ratio causing the increase of cAMP content in the brain may be anessential link in the pathogenesis of LP-induced fever.     

静脉灌注水杨酸钠对家兔EP性发热时体温升高和血浆、脑脊液cAMP含量变化的影响

为进一步分析内生致热原(EP)性发热时体温升高与脑脊液环磷酸腺苷(cAMP)含量变化间的因果关系,本文观察了静脉灌注水畅酸钠对家兔EP性发热时体温升高和血浆、脑脊液cAMP含量变化的影响,证明了cAMP很可能作为重要的中枢介质参与家兔EP性发热机制。静脉注射EP后家兔脑脊液cAMP含量的增高不是体温升高的结果。EP性发热时脑脊液中增加的cAMP不可能来源于血浆。水杨酸钠的抑热环节可能在cAMP增高之后。     

EFFECTS OF SODIUM SALICYLATE ON THE FEBRILE RESPONSE AND INCREASED LEVELS OF CYCLIC AMP IN CEREBRO-SPINAL FLUID DURING ENDOGENOUS PYROGEN-INDUCED FEVER IN RABBITS

To further evaluate the causality between endogenous pyrogen (EP)-induced fever andcyclic adenosine- 3', 5'- monophosphate (cyclic AMP) level. the effects of sodium salicylate(SS) on the febrile response and increased levels of cyclic AMP in both cerebrospinal fluid(c.s.f.) and plasma during EP- induced fever in rabbits were observed. The results suggestthat cyclic AMP is probably involved in the central mediation of EP-induced fever and thatincreased concentration of cyclic AMP in c.s.f. associated with EP- induced fever is not theresult of temperature elevation but appears to be caused by the increased synthesis in the cen-tral nervous system. In addition it is confirmed that blood is impossibly a contributorysource of increased cyclic AMP in c.s.f. during EP fever, and that SS may act subsequentto the increase in cyclic AMP.     

脑室灌注CaCl_2对家兔LP性发热时体温、血浆和脑脊液cAMP含量的影响

本文用新西兰兔进行实验,观察了侧脑室灌注CaCl_2对家兔的细胞致热原(LP)性发热时体温、血浆和脑脊液cAMP含量的影响。结果表明,静脉注射LP引起发热时,脑脊液cAMP含量明显上升,侧脑室灌注CaCl_2抑制了LP性发热时的体温升高,同时也抑制了脑脊液cAMP浓度的增高,表明Na~+/Ca~(++)比值上升导致cAMP增多,可能是LP性发热发病学的重要环节。