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A cell line (SMC-1) has been established from the resected tissue of a patient with malignant pleural mesothelioma which has been pathologically confirmed to be the mixed type. The cell line is characterized by the pleomorphy and multilaycred growth of the cells with the population-doubling time of approximately 32h, the highest mitotic index of 46—50‰ and the modal chromosome number of 69—70. Transplantation of the cells into the anireals can produce tumors bearing histological resemblance to the original material. The cultured cells, xenografted tumor cells and the cells from the host specimen show similar histochemical expressions. These data meet the requirements of a human malignant pleural mesothelioma cell line. The establishment of this cell line will serve as a useful tool in clinical research of diagnosis and treatment of this devastating disease. 相似文献
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本文报道以一例混合型人体恶性胸膜间皮瘤手术切除标本,经体外培养和建成一长期传代的细胞系,命名为SMC-1.该系细胞呈多形性,具有明显的重叠性生长特征.细胞群体倍增时间约32小时,最高分裂指数达46—50%,染色体众数为69—70.异种移植可产生类似原培养材料组织结构的肿瘤.培养细胞、异种移植之肿瘤及原培养材料三者具有同一的组织化学特征.这些说明这是一例人体恶性胸膜间皮瘤细胞系.SMC-1细胞系的建成,对研究愈后极为凶险的恶性间皮瘤提供了有利条件。 相似文献
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人体肺腺癌细胞系——SPC-A-1的建立及其生物学特性 总被引:3,自引:0,他引:3
从一例男性原发性肺腺癌患者手术中,取得胸膜转移结节,经离体培养建成细胞系,定名为:SPC-A-1。对本系细胞进行生物学特性的观察分析的结果是:细胞群体的倍增时间约30小时,细胞形态以多形性上皮样细胞为主。在电子显微镜下,细胞表面具多量微绒毛,细胞核形态不规则,胞质内有粘液性分泌颗粒和类似于肺泡Ⅱ型上皮细胞的板层体,张力原纤维束以及细胞间的桥粒结构。细胞的染色体众数范围为75—80,其中均有一对异常长的具有亚中着丝点的染色体。动物异种移植形成恶性肿瘤结节,其组织结构与该病例的临床肺腺癌标本相似。PAS和粘液卡红染色反应阳性。以上特性表明:本细胞系是一个人体原发性肺腺癌细胞系。 相似文献
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