ABSOLUTE CONFIGURATION OF (-)ANISODINE (A NEW GANGLIO BLOCKING AGENT) AND (-)ANISODINIC ACID

A new tropane alkaloid, (-)anisodlne (Ⅰ), was isolated from the plant of Anisodus tanguticus. It is a novel ganglio blocking agent. The absolute configuration of (-)anisodinic acid (Ⅶ), which-is the side chain of (-)anisodine, was determined by chemical correlation with (R) (-)-2-phenyl-1, 2-propanediol (Ⅳ) and (R) (-)-2-hydroxy-2-phenylpropionic acid (Ⅵ). Thereby (-)anisodine with the absolute configuration shown as (Ⅰ) is 6β, 7β-epoxy-1αH, 5αH-tropan-3α-ol (S) 2'-phenyl-2', 3'-dihydroxypropionate. Two new tropane alkaloids: 6β, 7β-epoxy-1αH, 5αH-tropan-3α-ol 2',3'-epox-ypropionate (Ⅲ) and 2'-phenyl-2'-hydroxypropionate (Ⅴ) were prepared and its physical constant is reported in this paper.     

左旋樟柳碱(新胆碱能阻滞剂)和左旋樟柳酸绝对构型的研究

本文从唐古特山茛菪植物(Anisodus tanguticus)中分离到樟柳碱(1)是一种新的胆碱能阻滞剂。樟柳碱边链樟柳酸(Ⅶ)经化学反应与(R)(—)-2-苯基-1,2丙二醇(Ⅳ)和(R)(—)-2-羟基-2-苯基丙酸(Ⅵ)发生关联,从而确定其不对称中心为“S”构型。樟柳碱的绝对构型如(Ⅰ)式所示,为3α-((S)-2′-苯基-2′,3′-二羟基丙酰氧基)-6,7β-环氧莨菪烷。还制备了两个新的托品生物碱(Ⅲ)和(Ⅴ)。