包结物晶析法选择分离辛夷挥发油中1，8-枝叶素

We used 1,1,6,6-tetraphenylhexa-2,4-diyne-1,6-diol(A) as the host molecule to selectively recognize the component 1,8-cineole(B) in the volatile oil of Flos Magnoliae(Xin Yi). The inclusion com-pound (A B) was formed as crystalline, and the structure was confirmed by means of IR, ^1H NMR, and single crystal X-ray diffraction, with the 1:2 molar ratios of the host to the guest. The component 1,8-cineole(B) was selectively isolated from the inclusion compound(A B) by Kugelrohr vaccum technology, and then further characterized by IR, ^1H NMR and ^13C NMR. The whole components in the volatile oil of Flos Magnoliae (Xin Yi) and the isolation effect of 1,8-cineole isolated from inclusion crystals were analyzed by GC and GC-MS, respectively. The result indicate that the good isolation effect is given by the inclusion method, with purity and yield of the component 1,8-cineole(B) separated from the volatile oil of Flos Magnoliae are 100% and 85%, respectively.     

包结物晶析法选择分离辛夷挥发油中1,8-桉叶素

主客体化学的分子识别在同分异构体选择分离、外消旋异构体光学拆分中已有广泛研究[1～3].我们利用中草药挥发油中化学组分的分子形状、几何拓扑性质、官能团数量和键力性质的不同,选定主体分子对挥发油中某一组分进行分子识别,并以结晶的形式从挥发油体系中离析出来,达到选择分离单一挥发油化学组分的目的[4～7].本文利用主体分子1,1,6,6-四苯基-2,4-己二炔-1,6-二醇(A)作为主体分子[8],以辛夷挥发油为研究对象,其主要成分1,8-桉叶素(B)为分子识别的客体分子,与化合物A形成稳定的包结物晶体(A+B),并从辛夷挥发油中析出,得到纯度为100%的…     

主客体包结法选择分离青花椒挥发油中的化学成分

以1,1,6,6-四苯基-2,4-己二炔-1,6-二醇为主体分子, 可简单、迅速地从青椒挥发油中选择分离出化学成分烯丙基茴香醚, 基于挥发油的用量, 收率为3.78%. IR, ¹H NMR, ¹³C NMR光谱和单晶衍射证实了包结化合物结构, 用气相色谱法评价了选择分离效果, 分离的烯丙基茴香醚气相色谱纯度为94.5%. 同时, 主体分子形成的隧道框架对茴香醛具有识别作用, 形成2∶1(主/客)物质的量比的特殊结构包结物晶体, 它是主客体分子物质的量比为1∶2包结物的超分子异构体.     

主客体包结法选择分离白花前胡的化学成分

以1,1,6,6-四苯基-2,4-己二炔-1,6-二醇为主体分子, 可简单、迅速地从白花前胡粗提物中选择分离有效成分3'-乙酰氧基-4'-β-羟基丙酰氧基-3',4'-二氢邪蒿内酯, 收率为0.17%. IR, ¹H NMR, ¹³C NMR光谱和单晶衍射证实了包结化合物的形成及其晶体结构, 并且用气相色谱方法(GC)评价了选择分离效果.