Preparation of 9,13-dicis double bonds locked retinoids

Synthesis of two retionids in which the 9, 13-dicis double bonds were locked in cycloalkene or thiophene was described. The key steps were the Wittig olefination of phosphonium salt 3 and 23 with aldehyde 14, followed by carbonylation of vinyl bromide 17 and 24 with carbon monoxide in the presence ofPd(PPh3)4.     

亚硝酸盐的烃化

亚硝酸盐的烃化问题,因受卤代烃的结构、亚硝酸盐的种类,以及溶剂等因素的影响而复杂化。本文旨在阐述这一复杂问题的反应历程、N—和O—烷基化产物主与次的条件以及实验室中,采用亚硝酸盐烃化法制备硝基化合物的可行方法。