排序方式: 共有3条查询结果,搜索用时 15 毫秒
1
1.
本文报道用高效液相色谱法和高效薄层色谱法分离磷酸醌基化学修饰的二核苷酸二尿苷硼烷磷酸酯,二胸苷硫代磷酸酯,二(2'-脱氧-2'-氟)尿苷及胞苷硫代磷酸酯的非对映异构体,所得到的非对映异构体的RF值和^31P-NMR化学移植之间的关系符合一般规律,即移动快的异构体有较高的位移植,移动慢的异构体有较的化学位移植。 相似文献
2.
本文综述了反义寡核普酸作为墓因表达抑制剂的原理和作用机理,作为人类疾病治疗剂的寡核普酸必须具备的性质。介绍了化学修饰的寡核普酸的种类、性质和目前已达到的研究及应用水平。 相似文献
3.
Diuridine 3', 5'-boianophosphate has been synthesized. Its diastereomers were separated and their configurations were tentatively assigned based on the selective snake venom phosphodiesterase (SVPDE) hydrolysis. It is found that, compared to the unmodified parent compound diuridine phosphate, the nucleophilicity and the stability of the modified compounds to SVPDE are significantly enhanced. 相似文献
1