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A new N-nitroso compound, N-2-methylpropyl-N-1-methylacetonyl-nitrosamine(MAMPNA), was found in millet and wheat flour inoculated with Fusarium moniliformeSheldon, a common species of fungi occurring in foods in Linxian County, after 8-day incu-bation and an addition of a small amount of NaNO_2. The compound has been identified byGC-MS and confirmed by synthesized MAMPNA. The present paper reports the isolationand detection of MAMPNA in moldy foods, and discusses the role of the fungus in processesof nitrosamine formation and possible biosynthetic approach of the new compound. 相似文献
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Methylisoamylnitrosamine, a carcinogenic N-nitroso compound, has been formed in glucose ammonium nitrate medium containing 150 mg of isoamylamine (a primary amine) inoculated with a common fungus (Fusarium moniliforme Sheldon), to which 400 mg NaNO_2 are added after incubation for 7—8 days at 28℃. No such compound has been found in control samples without fungi or isoamylamine. This paper reports a method of experimental synthesis of the nitrosamine by F. moniliforme strains 82—01 and 83—01, using isoamylamine and NaNO_2, as well as the analysis of the compound by GC/MS and GC/TEA. 相似文献
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一种存在于林县霉变玉米面中的新亚硝胺化合物——N-3-甲基丁基-N-1-甲基丙酮基亚硝胺(MAMBNA)已人工合成。利用新生金仓鼠肺成纤维细胞体外恶性转化模型,引入微粒体酶代谢激活系统检测了MAMBNA。实验结果,MAMBNA同已知的强化学致癌物N-甲基-N'-硝基-N-亚硝基胍和二乙基亚硝胺一样,能使体外培养的金仓鼠肺成纤维细胞发生恶性转化。证明MAMBNA是林县这一高癌地区的一种环境致癌物。本系统除可用于检测可疑环境致癌物外,尚可作为研究癌变机理的体外模型。 相似文献
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A new nitrosamine compound, N-1-methylacetonyl-N-3-methylbutyl-nitrosamine (MAMB-NA), isolated from corn bread inoculated with moulds commonly occurring in Linxian County,a high incidence area for esophageal cancer in North China was tested for its potentialcarcinogenicity in vitro. Baby hamster lung fibroblasts (BHL) were treated with MAMBNAin tissue culture medium containing liver microsome preparation of Aroclor 1254 treatedrat. Cell transformation was assessed by morphological changes, loss of density-dependentinhibition and unlimited growth in vitro, chromosome changes, colony formation on softagar, growth at low serum concentration, Con A agglutinability and tumor formation afterheterotransplantation into immunosuppressed newborne rats. Like the known carcinogensN-methyl-N'-nitro-N-nitroso-guanidine and diethylnitrosamine, MAMBNA was able to causemalignant transformation of cells cultured in vitro. 相似文献
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