排序方式: 共有4条查询结果,搜索用时 0 毫秒
1
1.
2.
本文以L-硒代胱氨酸为原料合成了L-硒-甲基硒代半胱氨酸(L-MSC),结构经~1H NMR、~(13)C NMR、HRMS和单晶X射线衍射(XRD)表征。L-MSC与甲硫氨酸氨肽酶2(MetAP2)5D6E蛋白的分子对接结果显示,两者具有较好的氢键作用,且两个氢键与ASP251残基形成键角为72.71°的六元刚性船式构象,L-MSC对HEPG2,SGC790和MCF7细胞的体外增殖抑制活性呈剂量依赖关系,在100μM浓度时的抑制率%分别为72.80±1.21、29.32±1.36和39.54±1.62(CCDC:1870311)。 相似文献
3.
以2-氯硒基-苯甲酰氯(1)为原料,在二氯甲烷溶液中与不同类型的胺(2a~2r)反应,合成了18个依布硒啉衍生物3a~3r(3i为新化合物),其结构经1H NMR, 13C NMR和HR-MS(ESI)表征。利用分子对接技术预测了化合物3a~3r与甲硫氨酸氨肽酶2(MetAP2)5D6E蛋白的亲和活性,并采用MTT法研究了化合物对食管癌细胞(EC109)的体外增殖抑制活性。结果表明:浓度为100 μg·mL-1时,2-(2-氯乙氧基-乙基)-1,2-苯并异硒唑-3(2H)-酮(3r)对EC109的增殖有良好的抑制活性,抑制率32%。 相似文献
4.
The title compound 4-(2-acetonyl-selanyl-benzamido) benzoic acid was synthesized and its structure was determined by NMR, HR MS and X-ray single-crystal diffraction. The crystal belongs to monoclinic, space group P2_(1/n), with a = 5.18537(19), b = 18.9308(7), c = 16.6586(5) ?, b = 95.857(3)°, V = 1626.72(10) ?~3, Z = 4, D_c = 1.536 g/cm~3, m = 3.302 mm~(-1), F(000) = 760, the final R = 0.0466 and wR = 0.1353 for 2308 observed reflections with I 2σ(I). In silico docking studies were carried out to evaluate the anti-ischemic stroke activities for twenty-one ischemic stroke associated proteins by Autodock 4.2 software. The title compound has better activity against ischemic stroke than Ebselen. 相似文献
1