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用新分离的巨大芽孢杆菌对映选择性水解缩水甘油苯基醚 总被引:1,自引:0,他引:1
Microbial epoxide hydrolases from bacterial and fungal sources?1? are hi ghly versatile catalysts for the asymmetric hydrolysis of chiral epoxides which are extensively employed as useful building blocks for the synthesis of various biologically active products in the pharmaceutical and agrochemical industries. Microorganism means allows an unlimited supply of these enzymes for preparative -scale applications. Phenyl glycidyl ether (PGE), an aryl epoxide, is a potenti ally useful compound in the synthesis of chiral amino alcohols and bioactive com pounds such as ?blockers. No suitable biocatalyst with sufficiently high enan tioselectivity (E?20) for the kinetic resolution of this compound was previ ously found among bacteria and fungi. This prompted us to screen epoxide hydrola se-producing microorganisms with higher enantioselectivity toward phenyl glycid yl ether from soil samples. 相似文献
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