组织工程及周围神经修复——Ⅲ.聚d,l-乳酸管诱导神经修复的研究

报道了聚d,l-乳酸在动物体内的降解速度和生物相容性,以及用聚d,l-乳酸为神经诱导管材料,对大鼠坐骨神经10 mm断缺修复的研究.通过肉眼观察、组织学检查、电子显微镜观察、以及腓肠肌湿重恢复率、电生理测定等方法和手段,对神经诱导再生过程进行了跟踪,揭示了随着神经的再生聚d,l-乳酸管形态的变化,且对神经修复的效果进行了评价.研究表明:聚d,l-乳酸管可有效地诱导10 mm断缺神经再生修复,是一类具有临床应用前景的神经修复组织工程材料.     

双目大出瞳直径光学系统观察舒适性设计

通过介绍人眼双目视觉的原理,重点对双目大出瞳直径光学系统中会聚角和聚焦差的影响进行了分析,剖析了其影响舒适性观察的因素和设计误区,指出设计双目大出瞳直径光学系统时应考虑不同瞳距以及非零视度观察仪器的情况,避免会聚角太大或为负值。会聚角应控制在（0~4 ）m-1（光焦度）范围内;而聚焦差越小越好,不应大于2 m-1。     

Tissue engineering and peripheral nerve regeneration (Ⅲ)——Sciatic nerve regeneration with PDLLA nerve guide

The biodegradation rate and biocompatibility of poly(d, / -lactide) (PDLLA) in vivo were evaluated. The aim of this study was to establish a nerve guide constructed by the PDLLA with 3-D microenvironment and to repair a 10 mm of sciatic nerve gap in rats. The process of the nerve regeneration was investigated by histological assessment, electrophysiological examination, and determination of wet weight recovery rate of the gastrocnemius muscle. After 3 weeks, the nerve guide had changed from a transparent to an opaque status. The conduit was degraded and absorbed partly and had lost their strength with breakage at the 9th week of postoperation. At the conclusion of 12 weeks, proximal and distal end of nerves were anastomosed by nerve regeneration and the conduit vanished completely. The results suggest that PDLLA conduits may serve for peripheral nerve regeneration and PDLLA is a sort of hopeful candidate for tissue engineering.     

组织工程及周围神经修复

报道了聚d,l-乳酸在动物体内的降解速度和生物相容性,以及用聚d,l-乳酸为神经诱导管材料,对大鼠坐骨神经10mm断缺修复的研究.通过肉眼观察、组织学检查、电子显微镜观察、以及腓肠肌湿重恢复率、电生理测定等方法和手段,对神经诱导再生过程进行了跟踪,揭示了随着神经的再生聚d,l-乳酸管形态的变化,且对神经修复的效果进行了评价.研究表明:聚d,l-乳酸管可有效地诱导10mm断缺神经再生修复,是一类具有临床应用前景的神经修复组织工程材料.