EXPERIMENTAL STUDIES ON THE LATE EFFECTS OF FEMALE SEX HORMONES

Inj. Hydroxyprogesterone Co. (EP) was injected i.m. into female Wistar rats, different strains of mice of both sex and Syrian golden hamsters with doses of 5--100 times the human contraceptive dose once or twice a month for 10--32 times. In some experiments EP was combined with whole-body 3 Gy gamma ray radiation once or twice. Results show that EP has obvious carcinogenicity and can enhance the gamma ray carcinogenicity, thereby increasing the tumor incidence or the ratio of malignant to benign turnouts. Carcinogenic mechanisms of EP have also been studied.     

雌性激素的远后效应实验研究

本文用复方己酸孕酮注射液(EP)给雌性大鼠以及不同品系雌性和雄性小鼠肌内注射,剂量按体重折合成人的5—100倍,每月注射1次或2次,共10—32次。部分实验与钴-60γ线联合应用,全身照射3Gy,1次或2次,观察其致癌和有害的非致癌效应。实验结果表明,EP具有明显的致癌作用;与γ线联合应用明显加重γ线的致癌作用。本文对EP的致癌机制也进行了讨论。