Developing and population analysis of a new multiplex panel of 18 microhaplotypes and compound markers using next generation sequencing and its application in the Shaanxi Han population

Compound marker consists of two different types of genetic markers, like deletion/insertion polymorphism and single nucleotide polymorphism in the genomic region of 200 bp, and microhaplotype consists of a series of closely linked single nucleotide polymorphisms in a small DNA segment (<300 bp), which show great potential for human identifications and mixture analyses. In this study, we initially selected 23 novel genetic markers comprising 10 microhaplotypes and 13 compound markers according to previously reported single nucleotide polymorphism or deletion/insertion polymorphism loci. Genetic distributions of these 23 loci in different continental populations showed that they could be used as valuable loci for forensic human identification purpose. Besides, high informativeness values (>0.1) were observed in six loci which could be further employed for forensic ancestry analyses. Finally, 18 loci were successfully developed into a multiplex panel and detected by the next generation sequencing (NGS) technology. Further analyses of these 18 loci in the studied Shaanxi Han population showed that 15 loci exhibited relatively high expected heterozygosities (>0.5). Cumulative power of discrimination (0.999 999 999 99 4835) of these 18 loci revealed that the multiplex panel could also be utilized for human identifications in the studied Shaanxi Han population.     

统计物理历史上的宏观不可逆性与微观可逆性之争

牛顿力学的时间可逆性与宏观热力学过程不可逆性的矛盾,很长时间以来一直是物理学和哲学中争论最多的问题之一．本文通过玻尔兹曼引入的H定理所引起的不可逆性之争,回顾了历史上关于这一问题的争论,并讨论了最近几十年关于这一问题研究的历史进展．在现代遍历性理论和混沌动力学的框架下,微观可逆与宏观不可逆之间的矛盾得到了很好的回答,并得到了很好的统一和解决.     

两类图的L(2.1)-标号数

图G的一个L(2.1)-标号是从顶点集V(G)到非负整数的一个函数f,使得若d(u,v)=1时,有|f(u)-f(v)|≥2;若d(u,v)=2时,有|f(u)-f(v)|≥1.图G的L(2.1)-标号数λ(G)是G的所有L(2.1)-标号下的跨度max{f(v):v∈V(G)}的最小数.图Fn+1*为扇图的路上每个顶点增加一个悬挂边得到的图.图Hn为轮图的圈上每个顶点增加一个悬挂边得到的图.本文确定了图Fn+1*与Hn的L(2.1)-标号数.     

组型为$2^u$的Kite-可分组设计的相交数问题

Kite-可分组设计的相交数问题是确定所有可能的元素对$(T,s)$, 使得存在一对具有相同组型 $T$ 的Kite-可分组设计 $(X,{\cal H},{\cal B}_1)$ 和$(X,{\cal H},{\cal B}_2)$ 满足$|{\cal B}_1\cap {\cal B}_2|=s$. 本文研究组型为 $2^u$ 的Kite-可分组设计的相交数问题, 设 $J(u)=\{s:\exists$ 组型为 $2^u$ 的Kite-可分组设计相交于$s$ 个区组\}, $I(u)=\{0,1,\ldots,b_{u}-2,b_{u}\}$,其中 $b_u=u(u-1)/2$ 是组型为$2^u$ 的Kite-可分组设计的区组个数. 我们将给出对任意整数 $u\ge 4$ 都有$J(u)=I(u)$ 且 $J(3)= \{0,3\}$.     

供应商回购承诺下的销售商存货质押融资决策

研究由一个供应商和销售商组成的供应链。销售商为中小企业,在受资金约束时无法通过自身信用获得所需融资,此时供应商可以为销售商贷款提供担保以提高其融资授信额度。本文采用销售商违约后剩余质押物的回购率来衡量供应商对融资风险的分担程度,对参与各方的存货质押融资决策进行了深入研究。结果表明:供应商的回购承诺提高了银行利润,在一定条件下提高了银行的质押率;并且,有回购承诺的融资决策在市场前景乐观情况下可以有效缓解销售商的融资困境。     

无机化学实验成绩评价标准与考核方式初探

根据我院实际情况,对无机化学实验考核方式进行了探讨,将实验教学考核成绩分成平时成绩、阶段成绩和结课成绩三个部分,建立了注重实验结果的同时更注重实验过程及实验技能的考核体系。     

在大学物理教学中适当增加混沌控制和同步内容的重要性

阐述了在大学物理教学中引入非线性理论知识,特别是引入混沌控制和同步内容的重要性,这对于让学生完整理解混沌科学理论是非常必要的．     

深度挖掘例题教学功能 培养学生的创新能力

本文对定积分和二重积分的几何意义进行了深入比较,通过实际问题的解决使学生更好地理解和掌握两种积分内在联系和区别,提高应用能力,培养创新意识.     

统计物理的微观动力学基础

统计的基本出发点是研究系统具有的随机性,不同系统在不同情形下的宏观热力学性质起源于系统内部随机性的差异,通过对宏观热力学系统的微观非线性动力学进行研究探索，我们可以进一步更为深入地理解物态方程、相变等诸多的宏观热力学现象。本文通过哈密顿系统的非线性动力学研究，以及遍历性理论的动力学随机性研究对此问题进行了分析，研究表明，动力学系统的全局性混沌是系统统计成立的根本要素，系统的无限大自由度（热力学极限）已不是决定性的因素，人们可以在此基础上建立少自由度系统的统计力学及热力学。     

Fabrication of a microporous Dy(III)-organic framework with polar channels for 5-Fu (fluorouracil) delivery and inhibiting human brain tumor cells

Porous metal-organic framework (MOF) is currently of great interest not only for its attractive structures but also because of its potential application in the biomedical field as effective drug delivery systems (DDSs). In this work, we have succeeded in the construction of a new porous lanthanide Dy(III)-organic framework, [Dy(BTC)(H₂O)]·(H₂O)(DMF) (1, BTC?=?1,3,5-bezenetricarboxylate, DMF?=?N,N-dimethylformamide), with abundant of open metal sites in the 1D channels though an one pot of solvothermal reaction. The structure of the obtained crystalline product has been fully determined by the X-ray single crystal diffraction, TGA, power X-ray diffraction, elemental analysis, and the gas sorption measurement. Due to the suitable window size and open metal sites functionalized 1D channels, the activated 1 (1a) was used for loading the anticancer drug 5-Fu (Fluorouracil) by a simple impregnation method. A moderate drug loading and pH-dependent drug-release behavior could be observed for 1a. Furthermore, as revealed by the MTT assay, this 5-Fu@1a system shows low toxicity toward the human normal cells and demonstrates obvious anticancer activity against human brain tumor cells SF17.