氧化栲胶溶液性质的研究

利用溶液的光学性质和渗透性质试验,得出氧化栲胶溶液和栲胶脱硫液属于高分子溶液以及生产上栲胶脱硫液属于胶体溶液的结论。     

云南废次烟叶中茄尼醇的提取及含量测定

 从云南低次烟叶中提取分离其中的茄尼醇,并用HPLC对每提取阶段样品中的茄尼醇含量进行测定.     

木城涧矿底煤复采平面模拟试验研究

通过对北京矿务局木城涧矿十槽煤不具备常规复采条件底煤复采的相似材料模拟试验研究，证明了回采上分层时顶板冒落情况和矿压显现规律，初步探明了留与不留煤皮假顶情况下，回采下分层时顶板岩层二次失稳情况和矿压显现规律，为类似条件底煤复采制定合理的复采方案、安全技术措施等提供重要的依据和指导作用。     

Inhibiting Effects of S.acus Linnaeus Extracts on GLT-82 Tumor Cell Lines

Hailong S.acus Linnaeus was chosen as the experimental material in the experiments and changes of cell morphology, forming rate of clone and changes of division index were conducted to identify the inhibiting effects of Hailong extract on human tumor cell lines (GLT-82). Four days after medication, most of the cells changed their normal morphology of tumor cells and became round, broken and even broke into pieces. The inhibiting rates could reach 75.1% on the fourth day. The division index reduced strongly and the clone could not form or the forming rate was very low. With the extract concentration increasing and the time prolonging, the inhibiting effect increased. These results indicate that Hailong has striking anti-tumor effects and will have a perfect future in the fields of treatment and prevention of cancer.     

文蛤(Meretrix Meretrix)凝集素(MML)的初步研究——Ⅰ.MML在文蛤体内的分布及纯化

在文蛤(Meretrix Meretrix)体内具有血球凝集活性的凝集素(简称MML),经实验证实仅分布于文蛤外套腔液中。向外套腔液中加入固体硫酸铵达40％时,可使99％的MML沉淀。用不同饱和度的硫酸铵溶液依次对上述沉淀进行抽提,得到MML粗制品溶液,其比活比原始外套腔液提高了约9.95倍,总活力回收达48％。最后用自制的人血浆糖蛋白一Sepharose 4 B亲合层析柱可将上述MML粗制品的比活再提高400多倍。结果与原始外套腔液比较,MML终产品的比活总共提高了4313倍,总活力回收达44.8％,在电泳鉴定时显示出单一的区带。     

稳定剂在蔬菜汁生产中应用的研究

就几种稳定剂对蔬菜汁的稳定作用作了比较研究,实验结果表明,在pH值为7,121℃—30s杀菌条件下,琼脂0.2％与CMC0.1％混合使用有较好的稳定作用,可以较好解决沉淀、变色等不稳定的问题。     

马脾铁蛋白铁核表层磷铁组成稳定性

马脾铁蛋白络合Ｆｅ２＋的能力与它的铁核表层磷酸盐和Ｆｅ３＋组成含量有关．ＯＨ－参与铁核表层组成，并迫使铁蛋白释放Ｆｅ３＋．用强还原剂还原铁核表层时，铁蛋白只能释放磷酸盐．在Ｆｅ２＋、磷酸盐和氧化剂存在下，铁蛋白能贮存原铁核总磷酸盐量的６０％的磷．     

Discovery of structurally diverse natural product antagonists of chemokine receptor CXCR3

The chemokines (CXCL9, CXCL10 and CXCL11) and associated CXCR3 receptor are expressed during the inflammatory process from multiple sclerosis, atherosclerosis or organ transplantation resulting in the recruitment of lymphocytes leading to tissue damage. It is hypothesized that blocking of the ligand/CXCR3 receptor interaction has potential to provide opportunity for development of agents that would block tissue rejection. In this paper, four classes of natural product inhibitors (IC₅₀ ranging 0.1–41 M) have been described that block the CXCR3 receptor interaction of IP-10 ligand. These include a cyclic thiopeptide (duramycin), polyketide glycosides (roselipins), steroidal glycosides (hypoglausin A and dioscin) and a novel alkyl pyridinium alkaloid that were isolated by bioassay-guided fractionation of the organic extracts derived from actinomycete, fungal, plant and marine sources and discovered using ¹²⁵ I IP-10/CXCR3 binding assay. Duramycin was the most potent with an IC₅₀ of 0.1 M. Roselipins 2A, 2B and 1A showed IC₅₀ values of 14.6, 23.5, and 41 M, respectively. Diosgenin glycosides dioscin, hypoglaucin A and kallstroemin D exhibited IC₅₀ values of 2.1, 0.47 and 3 M, respectively. A novel cyclic 3-alkyl pyridinium salt isolated from a sponge displayed a binding IC₅₀ of 0.67 M.     

柴达木盆地西部第三系烃源岩生烃动力学研究

对柴达木盆地西部第三系烃源岩进行了生烃动力学模拟实验,使用氯仿对产物抽提,结果表明抽提物的生成量不符合经典的生烃动力学规律,无法采用动力学方程模型进行分析,这可能是由于模拟实验中产生了有机酸盐的缘故.柴西烃源岩模拟实验中抽提物的生成可以概括为有机母质一有机酸盐一抽提物和有机母质一抽提物两条途径.     

一点红提取物抑菌活性研究

采用滤纸片法测定了一点红乙醇提取物对各种供试菌种的抑菌圈直径,同时就一点红提取物浓度以及加热处理对一点红提取物抑菌效果的影响进行了初步研究.结果表明:一点红乙醇提取物对G~-和G~-细菌有较强的抑制作用,而对霉菌抑菌效果不明显一点红提取物抑菌作用因菌种不同而最低抑菌质量浓度有所不同,大肠杆菌为0.05g·ml~(-1)、金黄色葡萄球菌为0.0625g·ml~(-1)、枯草芽孢杆菌为0.125g·ml~(-4),其抑菌圈直径分别为:大肠杆菌12.1mm、金黄色葡萄球菌15.3mm、枯草芽孢杆菌14.9mm,表明对常见细菌有较好的抑制作用,其在7h时抑菌效果最好.而对于真菌,黑根霉和米曲霉的最佳抑菌质量浓度分别为0.125g·ml~(-1)和0.05g·ml~(-1).在111℃湿热条件下20min后一点红提取物抑菌效果基本不变,说明一点红提取物具有良好的热稳定性.