复合Ginzburg-Landau方程的动力学行为分析

目前对非线性波动方程的研究大都仅限于静态波解,即所考虑的波解的波速、振幅、波宽都是不变的,考虑动态波解,以复合Ginzburg-Landau(CGLE)方程为研究对象,探讨其动力学行为.在假设示性函数的基础上,所研究的无穷维耗散系统转化为三维向量场,给出了简单分岔和Hopf分岔存在的条件,揭示了系统平衡点和极限环随系统参数的变化规律,分析了参数平面的不同区域中系统的相图特性,得到系统存在两种不同频率的周期解,此外还数值模拟了系统由倍周期分岔导致混沌的过程,揭示了系统的复杂性.     

Ultra-fast chromatographic micro-assay for quantification of diphenidol in plasma: application in an oral multi-dose switchability trial

Pharmacokinetics of diphenidol (DPN) is limited due to the lack of analytical methodology. Here, a micro-assay for DPN quantification was developed, by coupling ultra-performance liquid chromatography with tandem mass spectrometry. The procedure involved plasma precipitation and injection of supernatant into UPLC with an Acquitytrade mark C18 column. Detection was in positive electrospray, following transitions of m/z 310.3 --> 292.3 and m/z 275.3 --> 230.2 for DPN and chlorphenamine (internal standard), respectively. The method was linear with a range of 4-400 ng/mL, and a 2 min run time. This method was applied in a switchability trial, where both formulations of DPN were bioequivalent.     

An interlaboratory capillary zone electrophoresis-UV study of various monoclonal antibodies,instruments, and ε-aminocaproic acid lots

Capillary zone electrophoresis ultraviolet (CZE-UV) has become increasingly popular for the charge heterogeneity determination of mAbs and vaccines. The ε-aminocaproic acid (eACA) CZE-UV method has been used as a rapid platform method. However, in the last years, several issues have been observed, for example, loss in electrophoretic resolution or baseline drifts. Evaluating the role of eACA on the reported issues, various laboratories were requested to provide their routinely used eACA CZE-UV methods, and background electrolyte compositions. Although every laboratory claimed to use the He et al. eACA CZE-UV method, most methods actually deviate from He's. Subsequently, a detailed interlaboratory study was designed wherein two commercially available mAbs (Waters’ Mass Check Standard mAb [pI 7] and NISTmAb [pI 9]) were provided to each laboratory, along with two detailed eACA CZE-UV protocols for a short-end, high-speed, and a long-end, high-resolution method. Ten laboratories participated each using their own instruments, and commodities, showing excellence method performance (relative standard deviations [RSDs] of percent time-corrected main peak areas from 0.2% to 1.9%, and RSDs of migration times from 0.7% to 1.8% [n = 50 per laboratory], analysis times in some cases as short as 2.5 min). This study clarified that eACA is not the main reason for the abovementioned variations.     

Do we need to rethink collaborative trials?

The currently recommended design of collaborative trials (interlaboratory method performance studies) is examined in relation to the usefulness of the resulting statistics. It is suggested that larger experiments, without duplicate analysis, would be more informative.

同时考虑响应和毒性的Ⅱ期临床试验设计(英文)

肿瘤学研究常通过Ⅱ期临床试验设计来初步评价一个新的治疗方案的疗效,目前流行的方法是Simon的两阶段试验设计。不过他只关注反应率,即对肿瘤有抑制作用的病人比率。而在实际临床中,人们既想控制肿瘤的生长,也不希望毒性的副作用大。Conaway和Petroni基于治疗方案的疗效和安全性,提出一种Ⅱ期临床试验设计方法,对响应与毒性给以相同的权重。本文提出新的想法来处理安全性与疗效之间的平衡关系,主要思想是分开控制反应率和毒性的第一类错误。在Ⅱ期临床试验阶段,由于样本量较小的缘故不大可能同时控制反应率和毒性的第一类错误,我们可以根据实际临床需要将这两个第一类错误分别确定在不同的显著性水平。比如,如果我们更关注治疗方案的毒性多过疗效,可以将毒性的第一类错误定在较低的水平(如5%),而将反应率的第一类错误定在较高的水平(如10%或15%)。基于上面的思想,本文给出了寻找停止域和拒绝域的准则和样本量大小的确定公式。我们的方法较其它设计方案更稳健,而且能准确地控制感兴趣的参数(反应率或毒性)的第一类错误。另外,本文思想在概念上很直观,易于临床操作,尤其符合Ⅱ期临床试验设计小样本量的要求。     

Random fixed point theorems for commuting random operators in probabilistic functional analysis

Random fixed point theorems are of fundamental importance in probabilistic functional analysis. In complete separable metric space random fixed point theorems have been discussed by Bharucha-Reidf1/27, Hans[3], Itohf4,5J and the author’s papers[15-20].In this paper we obtain a random fixed point theorem for commuting random operators in probabilistic functional analysis. Our results generalize some important results also extend and unify some results in Jungck[6,7,8]t Das and Naiki[9] as well as Bhoades[10] adn ciric[11].     

基于多普勒速度声纳的水下航行器导航方法

提出由多普勒速度声纳、姿态测量组件和陀螺罗经组成导航系统,研究了速度解算和误差分析方法,给出了导航卡尔曼滤波算法．实船航行试验结果证明了导航方法的有效性.     

AutoNaut构型波浪滑翔器驱动机构数值模拟

波浪滑翔器是一款利用水下波浪动力转换机构实现波浪推进的水面无人探测平台,它出色的续航性能和无污染等优点受到了广泛的关注和认可。但是由于波浪滑翔器复杂的双体结构会导致其对作业水深有一定要求,且存在弱机动性、布放回收较为苛刻等缺点,制约了其全海况覆盖的发展。为了克服上述缺点,本文研发一种新型的利用升沉-俯仰共同驱动的波浪滑翔器(AutoNaut构型波浪滑翔器,ANWG)是极为必要的。首先,分析了ANWG推进机理,确定了其总体功能要求和设计目标,并完成了ANWG样机的总体结构设计;其次,进行了ANWG初步海试实验,对浮体船运动响应进行了分析,通过AQWA软件仿真计算,确定了ANWG浮体船的水动力参数,并基于浮体船的运动响应建立了被动扑动水翼的数值模型,得到了最佳的前后水翼弹簧刚度系数;最后开展了ANWG自航行海试实验,通过实验得到的推力和水翼摆角等因素与仿真结果进行了对比,结果验证了理论分析和仿真结果的正确性和可靠性。     

海上油田非均衡化学驱理念、模式及先期实践

海上油田储层非均质性较强,水驱后不论层间、层内,还是微观,都存在常规水驱技术手段难以高效动用大量剩余油的问题.为使油藏的驱替效果最大化,提出了一种适合海上油田特点的非均衡化学驱理念及模式,该模式针对储层4个层次的非均质性:层间非均质性、层内非均质性、平面非均质性以及微观非均质性,采取相应的非稳定、非连续、非均相与非对称的技术手段,最大限度地实现纵向和平面均衡驱替目的,并在海上J油田开展了非均衡化学驱模式的先期实践.结果表明,两口中心井明显见效,其中一口井含水由84.6％下降至70.2％,日产油提高70％;另一口井含水率由96.1％下降至88.0％,日产油提高173％,均取得了显著的技术经济效果.证明了该模式的可行性和有效性,适合海上的储层流体性质和开发特点,有望成为海上油田提高采收率的主要发展方向之一.