新媒体艺术设计的发展与影响

新媒体技术与艺术的高度结合很大地促进了艺术设计的发展，它促使新媒体艺术设计成为具有广阔发展前景的新领域。正确认识新媒体艺术设计的发展及其特征，深入探讨新媒体技术对传统艺术设计的影响，对聚力发展新型的艺术设计具有重要意义。     

Simultaneous quantitation of 23 bioactive compounds in Tanreqing capsule by high‐performance liquid chromatography electrospray ionization tandem mass spectrometry

Tanreqing capsule (TRQC) is a formulation frequently used in traditional Chinese medicine to treat pyrexia, cough, expectoration and pharyngalgia. Since the pharmacological action of traditional Chinese medicines is closely related to their complex and diverse constituents, understanding the exact composition of TRQC is important to elucidate its clinical effectiveness and mechanism of action as well as to establish quality control methods and resolve safety issues. Herein, we employed high‐performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry for the simultaneous quantitation of 23 bioactive compounds in five batches of TRQC; the analytes could be categorized into five types: organic acids (seven compounds), flavonoids (10 compounds), iridoids (two compounds), phenylethanoid glycosides (two compounds) and bile acids (two compounds). The calibration curves for all analytes showed good linearity (r > 0.9953), and the inter‐ and intra‐day precisions did not exceed 4.94 and 4.97%, respectively. The recoveries varied from 90.47% to 109.80%; the corresponding relative standard deviations (RSDs) did not exceed 4.94%; and the repeatability (RSD < 4.72%) and stability (RSD < 4.88%) were also within acceptable limits. Thus, this study can be viewed as a fundamental reference for setting comprehensive TRQC quality standards.     

Comparative in vivo constituents and pharmacokinetic study in rats after oral administration of ultrafine granular powder and traditional decoction slices of Chinese Salvia

Salvia miltiorrhiza, one of the most well‐known herbal medicines, is commonly used for the treatment of coronary heart diseases in China. Besides traditional decoction slices (TDS), another relatively new product of S. miltiorrhiza, ultrafine granular powder (UGP; D90 < 45 μm), is also increasingly being used. In this paper, a UHPLC‐LTQ‐Orbitrap MS technique was developed for a metabolite profile study after oral administration of UGP and TDS of S. miltiorrhiza. The results showed that the number of in vivo absorbed compounds from UGP was much greater than that from TDS, and different types of products from S. miltiorrhiza will have different metabolic processes in vivo. Furthermore, a UHPLC‐Q‐Trap MS/MS method for simultaneously determining four tanshinones (tanshinone IIA, dihydrotanshinone I, tanshinone I and cryptotanshinone) was established and applied to assess the pharmacokinetics of the two types of products. All of the analytes displayed significant higher area under the concentration–time curve and peak concentration after oral administration of UGP than after TDS, indicating that ultrafine powder product could improve the bioavailability and absorption of cryptotanshinon,tanshinone II A,dihydrotanshinonE I and tanshinone I in vivo. The present study provides scientific information for further exploration of the pharmacology of these two types of S. miltiorrhiza and offers a reference for clinical administration of S. miltiorrhiza.     

Metabonomics study of the effects of traditional Chinese medicine formula Ermiaowan on hyperuricemic rats

To explore the global mechanism of Ermiaowan on hyperuricemia regulation, the holistic function of Ermiaowan for hyperuricemia in rats was firstly assessed by the urinary metabonomics method which was based on ultra‐high performance liquid chromatography with electrospray ionization quadrupole time‐of‐flight mass spectrometry. The urinary targeted metabonomics approach combined with the serum biochemical analysis and histological assay was conducted to verify the research result. As a result, the significant differences in metabolic profiles were observed from Ermiaowan‐treated group, model group, and healthy control group by using multivariate statistical approaches. Twenty therapeutic related metabolites were identified in response to the therapeutic effects of Ermiaowan, which were mainly associated with purine metabolism, pyrimidine metabolism, tryptophan metabolism, tricarboxylic acid cycle, and tyrosine metabolism. In addition, the urinary targeted metabonomics study showed that Ermiaowan can better restore the disturbed pathways than Phellodendri cortex and Atractylodis rhizome. The biochemical assay and histopathological assay confirmed that Ermiaowan could significantly reduce uric acid and fibrosis areas of kidney. These results provided new insights into the mechanism of Ermiaowan on hyperuricemia.     

Efficient separation of high‐purity compounds from Oxytropis falcata using two‐dimensional preparative chromatography

The separation of high‐purity compounds from traditional Tibetan medicines plays an important role in investigating their bioactivity. Nevertheless, it is often quite difficult to isolate compounds with high purity because of the complexity of traditional Tibetan medicines. In this work, an offline two‐dimensional reversed‐phase preparative method was successfully developed for the separation of high‐purity compounds from Oxytropis falcata . Based on the analysis results, an ODS C18 prep column was used for first‐dimensional preparation, and 14.8 g of the crude sample was separated into five fractions with a recovery of 74.6%. Then, an XAqua C18 prep column was used to isolate high‐purity compounds in the second‐dimensional preparation because its separation selectivity is different with the ODS C18 stationary phase. As a result, eight compounds in the crude sample were isolated in more than 98% purity. This is the first report of trans‐cinnamic acid ( 1 ) and trifolirhizin ( 2 ) from Oxytropis falcata . This method has the potential to be an efficient separation method of high‐purity compounds from Oxytropis falcata and it shows great promise for the separation of high‐purity compounds from complex samples.     

卷泥片雕塑：当代钧窑造型艺术的新高度

1990年代中后期,卷泥片成型技艺引进钧窑造型艺术。钧窑卷泥片陶艺造型从理念上讲,需要创作者对泥性的深刻理解与把握,需要基本认知泥片成型工艺要求,需要熟知卷泥片肌理及其应用;从创作艺术素养和思想上讲,需要创作者从传统文化资源里汲取养素,在日常生活中寻求创作灵感。卷泥片造型技法进入钧窑成型艺术无疑将给当代中国钧窑带来极大的艺术提升潜力和张力。     

传统与现代二维视角下的大学生婚恋观建构

大学生在婚恋观的构建过程中，既要正视盲目追求现代性所带来的认识误区，又要考量传统婚恋思想中的美德伦理。实践意义上，物化与享乐主义思想，逃避义务、虚无责任的态度，违背善良风俗、突破道德底线的行为，不利于积极婚恋观的培养，而贤贤易色、相济相生、互敬互爱、忠贞不二等传统婚恋道德有助于健康婚恋观的生成。     

创新教育对传统教育的继承与革新试析

创新教育是以培养学生创新精神和创新能力为基本价值取向的教育。它源于时代的发展，但又非孤立存在。它以传统教育为基础——继承传统教育几千年来的教育理论，实践的精华，又和传统教育相对立——扬弃传统教育中陈旧、单一，定势的观念，并在对传统教育的继承．扬弃中发展，创立新的教育模式，以使教育更加适应知识经济时代飞速发展的需要。     

对《兄弟》的三种批评模式的批评

分析了《兄弟》的批评文章，主要有传统现实主义、文化批评和运用西方理论等三种批评模式在起作用。评价了三者的得失，认为《兄弟》运用超现实的手法，借鉴拉伯雷的怪诞现实主义形式，表达了对文革和改革两个动荡、巨变的时代精神之荒诞性的体认，是一部勇于“写当下”的探索之作。     

大连市农业产业化发展研究

农业产业化既具有全球普遍性，又具有区域特殊性，各地都可根据本地资源优势、区位优势发展本地区的农业产业化经营。以农业产业化的基本理论为指导，在深入调查研究的基础上，系统地论述了大连市发展农业产业化所具备的优势条件、发展现状及存在问题。通过调查研究、比较分析，结合地域优势、产品优势和经济优势提出了发展农业产业化的思路与对策，可为各级政府、相关部门、企业和农户发展农业产业化提供理论依据及借鉴参考。