民族高校工商管理专业实践教学体系创新研究

围绕工商管理专业培养具有较强实践能力和高素质管理人才的目标,分析当前实践教学中的误区,通过构建全社会参与的工商管理专业人才实践教学社会网络,建立贯穿大学四年学习全周期的五大实践教学培养体系,对工商管理专业学生进行基础素养实践能力和专业素养实践能力培养,探索工商管理专业人才实践能力培养模式和体系。     

高职院校图书馆新生入馆教育工作创新研究

对几种新生入馆教育方式的优缺点进行了比较分析,以山东商务职业学院图书馆为例,详细介绍了宣传片拍摄要领及技巧,提出了一种综合性的新生入馆教育新模式.     

大学英语教学中中国传统文化渗透路径探究

文化与语言有着密切的联系，一定的文化背景知识有助于促进语言应用能力的提高。大学英语教学的同时也应该是对文化的传授，英语教学不仅是语言知识的教授，更应该是文化知识的传播。从多模态视角出发，探究中国传统文化导入大学英语教学的必要性及途径，有助于提高当代大学生的英语识读能力及文化传播的能力。     

Identification of metabolites of rupestonic acid in rat urine by liquid chromatography combined with electrospray ionization quadrupole time‐of‐flight tandem mass spectrometry

Rupestonic acid, a potential anti‐influenza agent, is an important and characteristic compound in Artemisia rupestris L., a well‐known traditional Uighur medicine for the treatment of colds. In the present study, high‐performance liquid chromatography combined with electrospray ionization quadrupole time‐of‐flight tandem mass spectrometry was used to detect and identify the metabolites in rat urine after oral administration of rupestonic acid. A total of 10 metabolites were identified or partially characterized. The structure elucidations of the metabolites were performed by comparing the changes in accurate molecular masses and fragment ions with those of the parent compound. The results showed that the main metabolites of rupestonic acid in rat urine were formed by oxidation, hydrogenation and glucuronidation. A metabolism pathway was proposed for the first time based on the characterized structures. This metabolism study can provide essential information for drug discovery, design and clinical application of rupestonic acid. Copyright © 2014 John Wiley & Sons, Ltd.     

Chemical Profiles and Pharmacological Properties with in Silico Studies on Elatostema papillosum Wedd

The current study attempted, for the first time, to qualitatively and quantitatively determine the phytochemical components of Elatostema papillosum methanol extract and their biological activities. The present study represents an effort to correlate our previously reported biological activities with a computational study, including molecular docking, and ADME/T (absorption, distribution, metabolism, and excretion/toxicity) analyses, to identify the phytochemicals that are potentially responsible for the antioxidant, antidepressant, anxiolytic, analgesic, and anti-inflammatory activities of this plant. In the gas chromatography-mass spectroscopy analysis, a total of 24 compounds were identified, seven of which were documented as being bioactive based on their binding affinities. These seven were subjected to molecular docking studies that were correlated with the pharmacological outcomes. Additionally, the ADME/T properties of these compounds were evaluated to determine their drug-like properties and toxicity levels. The seven selected, isolated compounds displayed favorable binding affinities to potassium channels, human serotonin receptor, cyclooxygenase-1 (COX-1), COX-2, nuclear factor (NF)-κB, and human peroxiredoxin 5 receptor proteins. Phytol acetate, and terpene compounds identified in E. papillosum displayed strong predictive binding affinities towards the human serotonin receptor. Furthermore, 3-trifluoroacetoxypentadecane showed a significant binding affinity for the KcsA potassium channel. Eicosanal showed the highest predicted binding affinity towards the human peroxiredoxin 5 receptor. All of these findings support the observed in vivo antidepressant and anxiolytic effects and the in vitro antioxidant effects observed for this extract. The identified compounds from E. papillosum showed the lowest binding affinities towards COX-1, COX-2, and NF-κB receptors, which indicated the inconsequential impacts of this extract against the activities of these three proteins. Overall, E. papillosum appears to be bioactive and could represent a potential source for the development of alternative medicines; however, further analytical experiments remain necessary.     

微信公众平台在大学生安全教育中的应用

阐述微信公众平台的优势,分析利用微信公众平台开展大学生安全教育的可行性,通过突出信息推送功能、以案讲案、引导大学生参与平台建设等措施发挥微信公众平台载体作用,提出转变传统的安全教育观念、开发信息反馈功能、需要优秀编辑人员等完善微信公众平台运营的建议。     

基于WEB的在线答疑系统的设计与实现

根据登录者的身份，基于WWW技术的在线答疑系统设计为三大模块：学生模块、教师模块和系统管理员模块，它们可分别完成提问、回答和版务管理等功能．还探讨了系统主要的实现技术。     

简论高职教育的重点

本文简要分析了高职教育的重点，提出了高职教育的重点在于三高教育，即高素质、高技能和高能力的教育。     

大学新生入馆教育初探

对新生入学后出现的一些借阅问题进行了有针对性的分析，并提出了相应的解决办法。阐述了新生入馆教育的重要性及其在沟通师生关系、做好服务工作方面的深远意义。