风水理念对中国传统建筑选址和布局的影响

中国传统建筑文化内涵丰富,其各种建筑活动几乎无不受到所谓风水理念的深刻影响．从通俗和专业两个不同角度对“风水”这一概念进行了解释,并分析了中国源远流长的风水理念对传统建筑选址和布局的影响,从而总结出在风水理念影响下的中国传统建筑空间构成特征——重重封闭的内向性空间．     

数字图书馆建设的思考

简单阐述了数字图书馆的基本概念,介绍了与传统图书馆相比,数字图书馆具有的特点,指出数字图书馆建设的核心是数字资源建设,要将有地方特色、民族特色的资源数字化。     

基于SIMULINK《电力电子技术》虚拟实验的设计

基于SIMULINK建立虚拟实验,改进传统实验中只是静止不变的波形,使学生对动态响应过程有了更深的了解,而不再是抽象的内容．这样不仅能激发学生学习本课程的兴趣,而且提高教学效果．     

The Extracts of Polygonum cuspidatum Root and Rhizome Block the Entry of SARS-CoV-2 Wild-Type and Omicron Pseudotyped Viruses via Inhibition of the S-Protein and 3CL Protease

COVID-19, resulting from infection by the SARS-CoV-2 virus, caused a contagious pandemic. Even with the current vaccines, there is still an urgent need to develop effective pharmacological treatments against this deadly disease. Here, we show that the water and ethanol extracts of the root and rhizome of Polygonum cuspidatum (Polygoni Cuspidati Rhizoma et Radix), a common Chinese herbal medicine, blocked the entry of wild-type and the omicron variant of the SARS-CoV-2 pseudotyped virus into fibroblasts or zebrafish larvae, with IC₅₀ values ranging from 0.015 to 0.04 mg/mL. The extracts were shown to inhibit various aspects of the pseudovirus entry, including the interaction between the spike protein (S-protein) and the angiotensin-converting enzyme II (ACE2) receptor, and the 3CL protease activity. Out of the chemical compounds tested in this report, gallic acid, a phytochemical in P. cuspidatum, was shown to have a significant anti-viral effect. Therefore, this might be responsible, at least in part, for the anti-viral efficacy of the herbal extract. Together, our data suggest that the extracts of P. cuspidatum inhibit the entry of wild-type and the omicron variant of SARS-CoV-2, and so they could be considered as potent treatments against COVID-19.     

福建省重点田径传统项目学校运动员现状调查

采取文献资料法、问卷调查法、专家访谈法等方法,对福建省重点田径传统项目学校运动员进行了调查研究。通过调查研究发现福建省传统项目学校运动员存在着运动水平不高、文化课成绩差、学习与训练相互矛盾等问题,并针对这些问题提出引进少体校优秀运动员与教练员,采取形式多样的教学模式、加大资金的投入、建设现代化运动场馆和器材等发展对策。     

Promising Chemotherapy for Malignant Pediatric Brain Tumor in Recent Biological Insights

Brain tumors are the most widespread malignancies in children around the world. Chemotherapy plays a critical role in the treatment of these tumors. Although the current chemotherapy process has a remarkable outcome for a certain subtype of brain tumor, improving patient survival is still a major challenge. Further intensive treatment with conventional non-specific chemotherapy could cause additional adverse reactions without significant advancement in survival. Recently, patient derived brain tumor, xenograft, and whole genome analysis using deep sequencing technology has made a significant contribution to our understanding of cancer treatment. This realization has changed the focus to new agents, targeting the molecular pathways that are critical to tumor survival or proliferation. Thus, many novel drugs targeting epigenetic regulators or tyrosine kinase have been developed. These selective drugs may have less toxicity in normal cells and are expected to be more effective than non-specific chemotherapeutics. This review will summarize the latest novel targets and corresponding candidate drugs, which are promising chemotherapy for brain tumors according to the biological insights.     

Analysis of Plant–Plant Interactions Reveals the Presence of Potent Antileukemic Compounds

A method to identify anticancer compounds in plants was proposed based on the hypothesis that these compounds are primarily present in plants to provide them with an ecological advantage over neighboring plants and other competitors. According to this view, identifying plants that contain compounds that inhibit or interfere with the development of other plant species may facilitate the discovery of novel anticancer agents. The method was developed and tested using Magnolia grandiflora, Gynoxys verrucosa, Picradeniopsis oppositifolia, and Hedyosmum racemosum, which are plant species known to possess compounds with cytotoxic activities. Plant extracts were screened for growth inhibitory activity, and then a thin-layer chromatography bioautography assay was conducted. This located the major antileukemic compounds 1, 2, 4, and 5 in the extracts. Once the active compounds were located, they were extracted and purified, and their structures were determined. The growth inhibitory activity of the purified compounds showed a significant correlation with their antileukemic activity. The proposed approach is rapid, inexpensive, and can easily be implemented in areas of the world with high biodiversity but with less access to advanced facilities and biological assays.     

民族药物指纹图谱的建设策略

在总结中药指纹图谱技术的基础上,提出基于民族医学理论从生物学谱图、化学组分谱图、功效谱图三个方面建设民族药物指纹图谱的策略,以生物学谱图确定道地药材种质,以化学组分谱图确定药物成分组群,以功效谱图确定药物成分组群与疾病疗效的关系,通过民族药物指纹图谱完成民族传统医学的传承与发展。     

皖南传统民居建筑空间的生态适应性设计研究

当前,住宅节能的经济与社会效益十分重大.文章通过对皖南传统民居建筑与空间的生态适应性分析与研究,从民居建筑单体的空间设计与布局和建筑外部空间环境布局这两大方面分析皖南民居的生态适应性设计,以期对当代建筑绿色建筑、生态建筑的发展提供极有价值的经验和依据,更好服务于人类.     

民族传统体育文化产业与旅游产业的互动发展研究——基于保定市文化与旅游产业的调查分析

随着旅游业的不断发展,具有区域特色的民族传统体育文化产业与旅游的产业结合将会越来越密切,体育搭台、经贸唱戏的新模式将对旅游和民族传统体育双方面的发展起到重要作用。从保定市的体育文化产业与旅游产业的互动发展来看,将地区民族体育资源整合优化,形成规模化的民族体育旅游资源,可以使各种资源得到有效配置,实现区域可持续发展。