文化强省战略下山西城市居民余暇休闲特征调查研究

通过问卷调查和实地访谈,对太原市民余日医时间文娱活动与体育活动两方面的现状进行研究,在分析调查结果的基础上提出了一些相关建议。     

长尾理论与图书馆2.0微内容开发研究

阐明了长尾理论的基本观点,论述了图书馆2.0微内容的开发及其在图书馆信息服务中的应用,探讨了长尾理论与图书馆2.0微内容开发的结合对图书馆信息服务的启示。     

Discovery of Quinacrine as a Potent Topo II and Hsp90 Dual-Target Inhibitor,Repurposing for Cancer Therapy

Topo II and Hsp90 are promising targets. In this study, we first verified the structural similarities between Topo IIα ATPase and Hsp90α N−ATPase. Subsequently, 720 compounds from the Food and Drug Administration (FDA) drug library and kinase library were screened using the malachite green phosphate combination with the Topo II-mediated DNA relaxation and MTT assays. Subsequently, the antimalarial drug quinacrine was found to be a potential dual−target inhibitor of Topo II and Hsp90. Mechanistic studies showed that quinacrine could specifically bind to the Topo IIα ATPase domain and inhibit the activity of Topo IIα ATPase without impacting DNA cleavage. Furthermore, our study revealed that quinacrine could bind Hsp90 N−ATPase and inhibit Hsp90 activity. Significantly, quinacrine has broad antiproliferation activity and remains sensitive to the multidrug−resistant cell line MCF−7/ADR and the atypical drug−resistant tumor cell line HL−60/MX2. Our study identified quinacrine as a potential dual−target inhibitor of Topo II and Hsp90, depending on the ATP−binding domain, positioning it as a hit compound for further structural modification.     

Temperature-Resistant Intrinsic High Dielectric Constant Polyimides: More Flexibility of the Dipoles,Larger Permittivity of the Materials

High dielectric constant polymers have been widely studied and concerned in modern industry, and the induction of polar groups has been confirmed to be effective for high permittivity. However, the way of connection of polar groups with the polymer backbone and the mechanism of their effect on the dielectric properties are unclear and rarely reported. In this study, three polyimides (C0-SPI, C1-SPI, and C2-SPI) with the same rigid backbone and different linking groups to the dipoles were designed and synthesized. With their rigid structure, all of the polyimides show excellent thermal stability. With the increase in the flexibility of linking groups, the dielectric constant of C0-SPI, C1-SPI, and C2-SPI enhanced in turn, showing values of 5.6, 6.0, and 6.5 at 100 Hz, respectively. Further studies have shown that the flexibility of polar groups affected the dipole polarization, which was positively related to the dielectric constant. Based on their high permittivity and high temperature resistance, the polyimides exhibited outstanding energy storage capacity even at 200 °C. This discovery reveals the behavior of the dipoles in polymers, providing an effective strategy for the design of high dielectric constant materials.     

Polyphenolic Characterization,Antioxidant, Antihyaluronidase and Antimicrobial Activity of Young Leaves and Stem Extracts from Rubus caesius L.

Fruits are the main food part of the European dewberry (Rubus caesius L.), known as a source of polyphenols and antioxidants, while very little attention is paid to leaves and stems, especially young first-year stems. The purpose of this work was to analyze for the first time water and ethanol extracts obtained from young, freshly developed, leaves and stems of the European dewberry to determine their antioxidant and biological activity, whereas most of the papers describe biological properties of leaves collected during summer or autumn. As the phytochemical profile changes during the growing season, the quantitative and qualitative content of flavonoid glycosides and flavonoid aglycones was analyzed using reversed phase liquid chromatography/electrospray ionization triple quadrupole mass spectrometry (LC-ESI-MS/MS) with multiple reaction monitoring (MRM). The ability to inhibit hyaluronidase as well as antioxidant activity (2,2 diphenyl-1-picrylhydrazyl: DPPH and ferric antioxidant power: FRAP) were estimated. Extracts were also analyzed against Gram-positive and Gram-negative bacteria. The results of the qualitative phytochemical analysis indicated the presence of flavonoid aglycones and flavonoid glycosides, with the highest amount of tiliroside, hyperoside, isoquercetin, astragalin, rutin and catechin in ethanol extracts. DPPH and FRAP tests proved the high antioxidant activity of the extracts from leaves or stems and the antihyaluronidase assay revealed for the first time that water and ethanol extracts obtained from the stems exhibited the ability to inhibit hyaluronidase activity resulting in an IC₅₀ of 55.24 ± 3.21 and 68.7 ± 1.61 μg/mL, respectively. The antimicrobial activity has never been analyzed for European dewberry and was the highest for Clostridium bifermentans and Clostridium sporogenes—anaerobic sporulation rods as well as Enterococcus faecalis for both water and ethanol extracts.     

国家能源安全的作用机制分析

能源、经济、社会是一个复杂的大系统,通过它们之间关系的分析,界定国家能源安全的前向和后向作用机制。采用因素分析法,通过对前向作用机制的分析,归纳出影响国家能源安全的因素包括国际和国内两个方面,而国内方面又包括国内经济因素、安全控制力因素和能源本身因素三个部分;依据社会福利准则,构建效用函数模型,通过对后向作用机制的分析,说明促进国家能源安全对社会福利水平的提升,主要应该通过提高消费效用弹性(q值),降低贴现率(r值)和延长能源耗竭期(T年)三种途径。     

基于中小企业集群的知识创新研究

知识资源作为产业发展的新兴动力,和集群、创新有着密切的关系,它不仅能提供一种有利于集群创新的环境,还能为集群创新提供技术支持,从而加强了中小企业集群网络之间的联系,克服中小企业集群内部联系方面的劣势。主要分析了集群与知识、创新的关系,阐述了知识对中小企业集群中的重要性,提出了中小企业集群创新的影响因素,最后简要概括了中小企业集群知识创新的发展对策。     

论管理过程中的柔性化领导

随着科学管理的不断发展,传统的发号施令的领导方式越来越不适应当今社会各种组织发展的需要,柔性化的领导逐渐兴起并占据重要地位。这种以人为本的领导方式,要求领导者自身要有较强的亲和力和协调能力、较高的耐心和责任感、善于进行共情式领导。在管理中领导者要有效地实施柔性化管理,就必须以人为本,建立有效的激励机制;重视调控组织成员的情绪情感;加强人际沟通与协调,团结合作;提高非权力因素的影响力。     

基于模糊数学的网络学习评价系统

网络学习效果评价进行是网络教学与网络教学系统建设的重要工作，为此，在根据网络学习的特点，建立网络学习评价系统指标体系的基础上，引入模糊综合评价方法对网络学习进行了分析，提出了评价网络学习的模糊综合评价模型。实验表明，运用模糊综合评价方法评价网络学习效果比其他传统方法更加有效．     

獐子岛附近海域沉积物中氮和磷的分布来源及污染风险评价

【目的】为探讨北黄海獐子岛附近海域氮、磷的来源及其污染风险状况,对该海域表层沉积物中氮、磷的形态和分布特征进行分析。【方法】采用K2S2O8氧化法和HCl浸取法对獐子岛附近海域13个站位的表层沉积物中总氮(TN)、总磷(TP)及其无机和有机态的含量进行分析,并采用单因子标准指数法对氮、磷的污染水平进行评价。【结果】獐子岛附近海域沉积物中TN和TP的含量分别为0.192~1.357 mg/g和0.302~0.489mg/g,有机氮(ON)和无机磷(IP)是表层沉积物中氮和磷的主要存在形式,分别占TN与TP的90.93%和82.84%。沉积物中TN和TP在研究区域南部含量较高,这与沉积物粒度密切相关;而ON、有机磷(OP)两者都与有机碳(TOC)含量具有显著相关性,说明它们具有相似的来源。单因子标准指数法分析表明獐子岛附近海域沉积物中TP含量较低,标准指数均小于1;而TN含量相对较高,其标准指数为0.35~2.47。【结论】獐子岛附近海域沉积物中氮为陆源和自生混合来源,而磷主要是陆源输入;海域沉积物环境受到氮的污染。