习近平的新时代科技创新全球视野

 当前世界新一轮科技与产业革命正蓄势待发，中共中央总书记、国家主席、中央军委主席习近平以全球视野提出了新时代科技创新的指导思想。习近平指出：新时代中国必须采取科技创新全球视野系列举措，瞄准世界科技前沿，实施科技开放创新；构建世界科技命运共同体，实现世界各国合作共赢共享发展；采取"非对称性"赶超战略，取得后发超越；全面提升科技创新全球化，增强科技创新全球竞争力和世界影响力。分析表明，新时代习近平科技创新全球视野是引领和指导中国科技创新发展和建成世界科技强国的重大方略。     

“百病生于气”疾病观的针灸临床应用

 “百病生于气”见于《素问·举痛论》，几千年来始终是中医临床认识疾病、防治疾病的重要理论依据之一。对气的含义及气机失调致病的机制进行了梳理，得出了“百病生于气”的基本含义可以概括为气机失调是疾病发生的基本病机的结论，情志因素、精神心理是导致疾病发生的重要内因。分析认为“百病生于气”的理论对于针灸临床有重要指导意义，针灸诊疗过程中应注重“调气”“调神”，这是针灸取得佳效的根本保障。     

Modular Synthetic Approach to Carboranyl‒Biomolecules Conjugates

The development of novel, tumor-selective and boron-rich compounds as potential agents for use in boron neutron capture therapy (BNCT) represents a very important field in cancer treatment by radiation therapy. Here, we report the design and synthesis of two promising compounds that combine meta-carborane, a water-soluble monosaccharide and a linking unit, namely glycine or ethylenediamine, for facile coupling with various tumor-selective biomolecules bearing a free amino or carboxylic acid group. In this work, coupling experiments with two selected biomolecules, a coumarin derivative and folic acid, were included. The task of every component in this approach was carefully chosen: the carborane moiety supplies ten boron atoms, which is a tenfold increase in boron content compared to the l-boronophenylalanine (l-BPA) presently used in BNCT; the sugar moiety compensates for the hydrophobic character of the carborane; the linking unit, depending on the chosen biomolecule, acts as the connection between the tumor-selective component and the boron-rich moiety; and the respective tumor-selective biomolecule provides the necessary selectivity. This approach makes it possible to develop a modular and feasible strategy for the synthesis of readily obtainable boron-rich agents with optimized properties for potential applications in BNCT.     

A Photoluminescent Ag10Cu6 Cluster Stablized by a PNNP Ligand and Phenylacetylides Selectively and Reversibly Senses Ammonia in Air and Water

A photoluminescent bimetallic cluster [Ag₁₀Cu₆(bdppthi)₂(C≡CPh)₁₂(MeOH)₂(H₂O)](ClO₄)₄ ( 1 , bdppthi=N,N’-bis(diphenylphosphanylmethyl)-tetrahydroimidazole} was synthesized from the PNNP type ligand bdppthi generated in-situ. Upon excitation at 365 nm, 1 exhibited strong phosphorescent emission at 630 nm, which was selectively quenched by NH₃ in air or water. The sensing of NH₃ was rapid and recoverable, with detection limits of 53 ppm (v/v) in N₂ and 21 μmol/L (0.36 ppm, w/w) for NH₃ ⋅ H₂O in water. Cluster 1 could potentially serve as a bifunctional chemical sensor for the efficient detection of ammonia in waste-gas and waste-water.     

Molecular design of ambipolar redox-active molecules II: closed-shell systems

This mini-review highlights key structural features that should be taken into account when creating ambipolar redox-active closed-shell metal-free molecules. This type of compound is strongly required for the fabrication of all-organic ‘poleless’ batteries and semiconductors. The suggested strategies aimed at stabilization of both oxidized (cationic) and reduced (anionic) redox-states are based on the comprehensive analysis of the most successful structures taken from the recent publications.     

厦门小微企业知识产权托管治理的问题及对策

厦门市知识产权托管工作已由政府单向管理向以政府为主引导，企业、服务机构、行业协会、产业园区以及自贸区等载体参与其中的多元治理体系转变，并取得了良好的成效。但存在顶层设计缺失、托管机构服务能力不足、行业协会作用发挥不充分、氛围营造不够等问题。厦门市应通过加强监管力度、提高小微企业参与托管的意识、提升托管机构的服务能力、激励行业协会发挥作用、加强宣传等措施，进一步完善多元共治的治理体系，提升小微企业知识产权托管治理效能。     

南方丝绸之路对大理的影响及当前的对策

大理历史悠久,文化灿烂,风光秀丽,古道纵横。过去南方丝绸之路对大理的经济、政治、交通、文化、宗教等有较大的影响,今天在国家"一带一路"的大战略背景下,大理应该怎么办,大理学院应该怎么办,这是当代学人的新课题。以古代南方丝绸之路为出发点,建议今天大理的"一带一路"定位为交往之路、人情之路。     

介绍一个与材料相关的研究型综合化学实验——壳聚糖的制备与表征

在中国科学技术大学夏季学期的研究型实验课程"化学科研基础训练"中开设"壳聚糖的制备与表征"综合实验,以龙虾壳为原料,通过除蛋白、脱盐、脱色、脱乙酰等一系列反应,制备得到目标产物壳聚糖。运用红外光谱、核磁共振仪、黏度法、滴定等对产品的结构及性能进行表征。     

高职院校图书馆新生入馆教育工作创新研究

对几种新生入馆教育方式的优缺点进行了比较分析,以山东商务职业学院图书馆为例,详细介绍了宣传片拍摄要领及技巧,提出了一种综合性的新生入馆教育新模式.