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排序方式: 共有120条查询结果,搜索用时 16 毫秒
61.
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Lingyu Li Yiming Chen Yingli Ma Zhong Wang Tao Wang Yinfeng Xie 《Molecules (Basel, Switzerland)》2021,26(18)
Taxus mairei is an important source for industrial extraction of taxol in China. However, the standard and steps of extraction are currently not uniform, which seriously affects the taxol yield. In the present study, the influence of four factors (methanol concentration, solid-liquid ratio, ultrasonic extraction temperature, and ultrasonic extraction time) on the taxol yield was successively explored in T. mairei. A response surface methodology (RSM) was used to optimize the extraction process based on the single-factor experiments above. The optimal conditions were as follows: methanol concentration was 90%, solid-liquid ratio was 1:15 (g/mL), ultrasonic extraction temperature was 40 °C and ultrasonic extraction time was 60 min. Moreover, the twigs and needles from T. mairei with different tree ages were treated by the optimum extraction process, which further revealed temporal and spatial distribution of taxol in the reproducible tissues. Interestingly, the taxol content was relatively higher in needles of T. ‘Jinxishan’ (a cultivar from T. mairei with yellow aril, FY), but was less in FY twigs. The accumulation of taxol in twigs and leaves of females (with red aril, FR) was significantly higher than that of males (M); however, the content showed a decreasing trend with the increasing tree ages. Therefore, it is suitable to increase the proportion of female trees especially the FY leaves as raw materials for the industrial production of taxol from T. mairei, and the tree ages should be better controlled at 3–7 years. 相似文献
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人工栽培南方红豆杉紫杉醇的含量分析 总被引:7,自引:1,他引:6
采用高效液相色谱法对人工栽培南方红豆杉枝、叶、皮、种子中紫杉醇的含量进行测定,并与文献报道的东北红豆杉、南方红豆杉、云南红豆杉的紫杉醇含量比较.结果表明,人工栽培南方红豆杉种子、枝条、叶和皮中的紫杉醇含量分别是0.01256%,0.00193%,0.00102%和0.01483%,它们均有开发利用价值,研究为合理开发利用人工栽培南方红豆杉枝提供了依据. 相似文献
66.
Wang Xing Cheng Dai Yin Peng Chuan Hua Lu Cheng Wu Fang 《Russian Journal of Electrochemistry》2008,44(9):1052-1057
The Cysteamine/DNA/SWNTs-film-modified Au electrode was successfully prepared, and its electrochemical behavior is investigated
by cyclic voltammetry (CV). The modified electrode exhibited a pair of stable and well-defined redox peaks, with the formal
potentials (E
0′ at about −0.032 V (vs. SCE) in 0.1 M pH 7.0 phosphate buffer solution (PBS). The dependence of E
0′ on solution pH indicated that the direct electron transfer reaction of the Cysteamine/DNA/SWNTs film is the same electron
transfer coupled with the proton participating in the reaction process. Taxol is an anticancer drug; it interacts with microtubule
proteins in a manner that catalyzes the formation of microtubules from tubulin and stabilizes the resulting structures. Using
the Cysteamine/DNA/SWNTs-film-modified Au electrode, we study the interaction between DNA and Taxol studied. A UV-Vis experiment
is performed to confirm this interaction.
Published in Russian in Elektrokhimiya, 2008, Vol. 44, No. 9, pp. 1133–1139.
The text was submitted by the authors in English. 相似文献
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Yue Yuan Lin Wang Wei Du Zhanling Ding Jia Zhang Tao Han Linna An Prof. Huafeng Zhang Prof. Gaolin Liang 《Angewandte Chemie (International ed. in English)》2015,54(33):9700-9704
Multidrug resistance (MDR) remains the biggest challenge in treating cancers. Herein we propose the intracellular self‐assembly of nanodrugs as a new strategy for overcoming MDR. By employing a biocompatible condensation reaction, we rationally designed a taxol derivative Ac‐Arg‐Val‐Arg‐Arg‐Cys(StBu)‐Lys(taxol)‐2‐cyanobenzothiazole (CBT‐Taxol) which could be subjected to furin‐controlled condensation and self‐assembly of taxol nanoparticles (Taxol‐NPs). In vitro and in vivo studies indicated that, compared with taxol, CBT‐Taxol showed a 4.5‐fold or 1.5‐fold increase in anti‐MDR effects, respectively, on taxol‐resistant HCT 116 cancer cells or tumors without being toxic to the cells or the mice. Our results demonstrate that structuring protease‐susceptible agents and assembling them intracellularly into nanodrugs could be a new optimal strategy for overcoming MDR. 相似文献
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Govind P. KalenaPadmanava Pradhan Vedavati S. PuranikAsoke Banerji 《Tetrahedron letters》2003,44(10):2011-2013
On irradiation, 2-methyl-2-ethenyl naphtha-4-chromanone 1 undergoes an unusual intramolecular arene-alkene photocyclisation, followed by rearrangements to give a [5.3.1.06,1]benzotricycloundecene, 5. 相似文献