硒水平对食管癌发病率影响的初步研究

对比研究显示食管癌高发区磁县土壤,粮食,水和正常人发硒的质量分数「分别为０．４２＊１０＾－９,０．０８＊１０＾－９,１．２４＊１０＾－９,１．１６＊１０＾－６」最高,中发区临漳县次之「分别为０．１７４＊１０＾－９,０．０４９＊１０＾－９,０．６８＊１０＾－９,０．９７＊１０＾－６」,低发区魏县最低「分别为０．１４８＊１０＾－９,０．０２６＊１０＾－９,０．２４＊１０＾－９,０．９１＊１０＾－６」,     

直肠腔内超声检查对直肠癌的诊断价值

通过腔内超声估价直肠癌浸润情况。方法;疑有直肠癌患者２１例,术前行直肠腔内超声检查。结果;经手术和是证实为直肠癌患者２１例,直肠腔内超声癌灶检出率为９０．５％,超声判断癌灶浸润深度与病理诊断符合率为９４．７％。结论：直肠腔内超声检查是判断直肠癌浸润深度,侵及肠壁周径,纵长长度的理想手段。     

Thermosensitive mucoadhesive gel formulation loaded with 5-Fu: cyclodextrin complex for HPV-induced cervical cancer

Human Papilloma Virus (HPV) infections are the major cause of cervical cancers. To achieve a better therapeutic efficacy and patient compliance in the treatment for HPV-induced cervical cancers, anticancer agent 5-fluorouracil has been formulated in a vaginal gel using the thermosensitive polymer Pluronic^® F127 together with alternative mucoadhesive polymers e.g., hyaluronic acid, Carbopol 934 and hydroxypropylmethylcellulose. To increase its aqueous solubility and to achieve the complete release of 5-FU from the gel, the drug was incorporated as its inclusion complex with 1:1 molar ratio with either β-cyclodextrin or hydroxypropyl-β-cyclodextrin. Following the characterization of drug:CD complexes, thermosensitive gel formulations containing different mucoadhesive polymers and the drug in free or complexed form were characterized in vitro by determining the gelation temperature and the rheological behavior of different formulations along with the in vitro release profiles of these formulations in pH 5.5 citrate buffer. It was observed that complexation with cyclodextrin accelerated the release of 5-FU with the exception of formulation containing Carbopol 934 as mucoadhesive polymer. As far as rheological properties are concerned, favorable thermosensitive in situ gelling properties were obtained with formulations containing HPMC as mucoadhesive polymer. Complete release of 5-FU from gels were obtained with both complexes of β-CD and HP-β-CD and cytotoxicity studies against HeLa human cervical carcinoma cells demonstrated that 1% 5-FU:CD complexes were equally effective as 1% free 5-FU indicating better therapeutic efficacy with lower dose.     

直肠癌患者头发微量元素分析

应用装存EPM-810Q电子探针的扫描分析电镜，对53例直肠癌患者作单根头发中镁、铝、镉，钙，铬、铁、铜、锌、铅、锰、硒11种微量元素分析。并与健康对照组进行比较，结果表明：直肠癌患者头发中镁、铝，钙含量明显低于正常。     

口腔癌相关唾液肿瘤生物标志物的分析检测研究进展

口腔癌系头颈部癌，癌组织均位于口腔内，其非侵入性早期诊断是减少该病死亡的有效手段.唾液系口腔癌变相关物质首先释放进入的体液，取材方便，安全无创，是口腔癌普查筛选、早期诊断的首选指标.本文对唾液肿瘤生物标志物的种类、目前国内外常用的检测方法进行概述，重点阐述新型电化学生物传感方法在口腔癌相关唾液肿瘤生物标志物检测方面的相关应用及其最新研究进展.并对口腔癌相关唾液肿瘤生物标志物电化学传感技术的未来发展方向提出展望，拟为其深入研究与应用提供参考.     

Electrochemical iodination of C-methyl derivatives of dodecahydro-7,8-dicarba-nido-undecaborate anion

By electrochemical iodination of potassium 7-methyl-7,8-dicarba-nido-undecaborate and potassium 7,8-dimethyl-7,8-dicarba-nido-undecaborate, their monoiodine derivatives (extracted as tetramethylammonium salts) are synthesized. Their structure is confirmed by NMR and IR spectra and also by elemental analysis data.     

Synthesis and Crystal Structure of 3,3‘—（Hexane—1,6—diyl）bis（1—acetyl—5,5—dimethylhydantoin）,a New Inducer of Differentiation

The title compound C20H30N4O6, Mr = 422.48)was synthesized and its crystal structure was determined by X-ray diffraction method. It crystallizes in the triclinic system, space group P ī with cell parameters: a = 8.330(2), b = 8.468(2), c = 16.017(3) A, α = 97.30(3), β = 92.33(3), γ = 103.94(3)o, V = 1084.7(4) A3, Dc = 1.294 g/cm3, Z = 2, F(000) = 452 and μ = 0.096 mm-1. The structure was refined to R = 0.0483 for 3732 observed reflections with I>2(I) and wR = 0.1335 for 4828 unique reflections. The hydantoin rings are planar and the two ring planes of one molecule are paralleled to each other.     

Derivatives of the closo-dodecaborate anion and their application in medicine

The paper presents a comparative analysis of the possibilities and characteristic features of the application of various polyhedral boron compounds, viz., the closo-decaborate anion [B₁₀H₁₀]^2–, the closo-dodecaborate anion [B₁₂H₁₂]^2–, the carba-closo-dodecaborate anion [CB₁₁H₁₂]^–, carboranes C₂B₁₀H₁₂, and the bis(dicarbollide) complexes [M(C₂B₉H₁₁)₂]^– (M = Fe, Co, or Ni), in boron neutron capture therapy (BNCT) for cancer. The requirements on compounds used in BNCT are formulated and the advantages of the application of the closo-dodecaborate anion are considered. The data on the synthesis of various derivatives of the closo-dodecaborate anion, which either already found use in BNCT or are most promising in this field, are summarized. The possibilities of the application of agents derived from the closo-dodecaborate anion in medical diagnostics are discussed.     

基于荧光效应的小分子抗癌药物释放体系研究进展

近年来,随着癌症发病率的不断升高,癌症治疗技术的更新和发展显得尤为重要,特别是化学疗法(Chemotherapy)的提出促进了荧光小分子抗癌药物释放体系的研究。 将具有荧光效应的有机小分子与抗癌药物结合在一起,使得药物释放体系表现出低毒性、优异的癌细胞靶向性和方便药物跟踪监测等特点。 因此,设计不同性能的前药可以研究抗癌药物释放的动力学过程,为实现癌症的精准治疗提供有力的工具。 本文主要介绍了基于喜树碱、SN-38和阿霉素等前药的研究进展,并对其发展前景作了展望。     

5-Hydroxytryptamino-induced calcium sparks in cultured rat stomach fundus smooth muscle cells

With the imaging fluorescence probe of Ca2+ (fluo-3) and a laser scanning confocal micro-scope, the spontaneous localized calcium release event was first discovered in resting rat cardiac myocytes by Cheng[1] in 1993. A mathematical simulation is developed with computer in order to reveal the effect, which is immediately suggested that these events are likely to reflect the local-ized release of Ca2+ from a small cluster of ryanodine-sensitive Ca2+ release channels in sar-coplasmic reticulum …