Poly(N-isopropylacrylamide)-based thermo-responsive surfaces with controllable cell adhesion

Poly(N-isopropylacrylamide) (PNIPAAm)-based thermo-responsive surfaces can switch their wettability (from wettable to non-wettable) and adhesion (from sticky to non-sticky) according to external temperature changes. These smart surfaces with switchable interfacial properties are playing increasingly important roles in a diverse range of biomedical applications; these controlling cell-adhesion behavior has shown great potential for tissue engineering and disease diagnostics. Herein we reviewed the recent progress of research on PNIPAAm-based thermo-responsive surfaces that can dynamically control cell adhesion behavior. The underlying response mechanisms and influencing factors for PNIPAAm-based surfaces to control cell adhesion are described first. Then, PNIPAAm-modified two-dimensional flat surfaces for cell-sheet engineering and PNIPAAm-modified three-dimensional nanostructured surfaces for diagnostics are summarized. We also provide a future perspective for the development of stimuli-responsive surfaces.     

一种参数自调整风电功率预测模型

为了提高风电功率预测精度,提出一种参数自调整风电功率预测模型.通过加权递推最小二乘(SWWRLS)方法建立预测模型,侧重当前数据对预测结果的影响,排除了历史数据对预测结果的干扰.模型通过加权递推的方法节省了存储空间,并且提高了模型对外界环境数据变化的自适应性.最后,分别采用支持向量机(SVM)方法、卡尔曼滤波(KF)方法和本文SWWRLS方法,以辽宁省某风电场的真实历史数据进行风电功率预测对比实验,实验结果表明,本文方法建立的模型具有较高的预测精度.     

滑动窗口下数据流完全加权最大频繁项集挖掘

针对当前关于数据流加权最大频繁项集WMFI(weighted maximal frequent itemsets)的研究无法有效地处理频繁阈值和加权频繁阈值不一致情况下WMFI的挖掘问题,提出了完全加权最大频繁项集FWM FI(full w eighted maximal frequent itemsets)的概念.为了减少naive算法在处理滑动窗口下完全加权最大频繁项集挖掘时存在的冗余运算,提出了FWMFI-SW(FWMFI mining based on sliding window over data stream)算法.所提出的算法通过基于频繁约束条件的优化策略减少了naive算法中M ax W优化策略的无效调用次数;采用编辑距离比率作为WMFP-SW-tree的重构判别函数,可以有效减少该树的重构次数.实验结果表明FWMFI-SW算法是有效的,且比naive算法更有时间优势.     

基于信道占用率的Ad Hoc网络自适应公平性算法

Ad Hoc网络中,节点通过竞争信道完成通信,如果竞争窗口值选取策略不合理,则容易造成公平性问题.在分析现存典型公平性算法的实现机制基础上,提出了信道占用率的概念,设计了一种基于信道占用率的Ad Hoc网络自适应公平性算法.根据节点对通信历史及当前信道占用率与理想信道占用率之间的关系,将通信情况分为4种类别,再结合当前网络负载情况,动态设置竞争窗口值.仿真结果表明,该算法在改善吞吐量的同时,显著提高了节点信道接入公平性,在各种负载条件下表现良好,优于BEB、MILD、MIMD和NAVB等算法.     

Nd3+ Sensitized Fluorescent Nanoprobes for Vascular Imaging in the Second Near Infrared Window北大核心CSCD

In recent years,in comparison to the light in the visible range（400~700 nm）and first near-infrared window（NIR-Ⅰ,700~1000 nm）,the light in the second near-infrared window（NIR-Ⅱ,1000~ 1700 nm）possess the merits of the lowest optical scattering and absorption in the bio-tissue. So NIR-Ⅱ fluorescence imaging with deeper tissue penetration depths,high spatiotemporal resolution and signal to noise ratio（SNR）plays an important role in the fields of angiography,lymphangiography and so on. Herein, Nd3+ sensitized fluorescent nanoprobe （U/DNPs,NaGdF4 ∶Yb（18% mole fraction）,Ho（2%）,Ce（30%） @NaGdF4 ,Nd（60%）@NaGdF4 ,Nd（10%）） with core-shell-shell is synthesized through high-temperature coprecipitation and epitaxial growth method. Under the irradiation of 808 nm,the NIR-Ⅱ fluorescence at 1056 nm and 1332 nm are obtained via down-conversion process for further vascular imaging. Furthermore,it can emit red upconversion fluorescence with high red to green（R/G）ratio（I647 /I540 = 22. 6）,possessing greatly potential application for photodynamic therapy. After successful modification of polyvinyl pyrrolidone（PVP） via ligand-exchange strategy,the U/DNPs-PVP nanomaterials possess excellent solubility in water and good biocompatibility,and can achieve the NIR-Ⅱ fluorescence vessels imaging with spatial resolution of 336. 3 µμm in vivo. © 2022, Science Press (China). All rights reserved.     

Smart Coatings Prepared via MAPLE Deposition of Polymer Nanocapsules for Light-Induced Release

Herein, smart coatings based on photo-responsive polymer nanocapsules (NC) and deposited by laser evaporation are presented. These systems combine remotely controllable release and high encapsulation efficiency of nanoparticles with the easy handling and safety of macroscopic substrates. In particular, azobenzene-based NC loaded with active molecules (thyme oil and coumarin 6) were deposited through Matrix-Assisted Pulsed Laser Evaporation (MAPLE) on flat inorganic (KBr) and organic (polyethylene, PE) and 3D (acrylate-based micro-needle array) substrates. SEM analyses highlighted the versatility and performance of MAPLE in the fabrication of the designed smart coatings. DLS analyses, performed on both MAPLE- and drop casting-deposited NC, demonstrated the remarkable adhesion achieved with MAPLE. Finally, thyme oil and coumarin 6 release experiments further demonstrated that MAPLE is a promising technique for the realization of photo-responsive coatings on various substrates.     

Polyethylene Glycol Functionalized Graphene Oxide Nanoparticles Loaded with Nigella sativa Extract: A Smart Antibacterial Therapeutic Drug Delivery System

Flaky graphene oxide (GO) nanoparticles (NPs) were synthesized using Hummer’s method and then capped with polyethylene glycol (PEG) by an esterification reaction, then loaded with Nigella sativa (N. sativa) seed extract. Aiming to investigate their potential use as a smart drug delivery system against Staphylococcus aureus and Escherichia coli, the spectral and structural characteristics of GO-PEG NPs were comprehensively analyzed by XRD, AFM, TEM, FTIR, and UV- Vis. XRD patterns revealed that GO-PEG had different crystalline structures and defects, as well as a higher interlayer spacing. AFM results showed GONPs with the main grain size of 24.41 nm, while GONPs–PEG revealed graphene oxide aggregation with the main grain size of 287.04 nm after loading N. sativa seed extract, which was verified by TEM examination. A strong OH bond appeared in FTIR spectra. Furthermore, UV- Vis absorbance peaks at (275, 284, 324, and 327) nm seemed to be correlated with GONPs, GO–PEG, N. sativa seed extract, and GO –PEG- N. sativa extract. The drug delivery system was observed to destroy the bacteria by permeating the bacterial nucleic acid and cytoplasmic membrane, resulting in the loss of cell wall integrity, nucleic acid damage, and increased cell-wall permeability.     

用混合遗传算法解决有时间窗的车辆路径规划问题

有时间窗约束的车辆路径规划问题是一种NP-hard问题,这种问题往往采用遗传算法来解决.但是传统的遗传算法本身存在的不足将严重影响整个算法的性能.本文设计了一种混合遗传算法,并进行了仿真试验.试验结果表明,用这种算法求解带有时间窗约束的车辆调度问题,可以在一定程度上克服上述问题,从而得到较高质量的解.     

"校园一卡通"系统的设计

文章在对高校使用"校园一卡通"进行分析[1]的基础上,以IC卡为信息载体,对校园消费、管理系统的组成、硬件的构成及网络系统进行了设计.