数字图书馆信息资源组织浅探

简述了数字图书馆的含义，数字图书馆信息资源组织中要遵循的选择性、标准化、多雏性和安全性原则及信息资源的获取方式。     

谈谈随书光盘的管理与利用

鉴于目前随书光盘的分类、著录、管理尚无统一规范的标准，介绍了集美大学图书馆利用856字段对随书光盘加以管理与利用的情况，旨在供同行参考与借鉴。     

关于加强高校图书馆期刊工作的思考

论述了加强高校图书馆期刊工作的问题，包括期刊的合理选购，期刊的开发、利用与管理，以及期刊管理人员综合素质的培养。     

Distributed and Parallel Component Library

Software component library is the essential part of reuse-based software development. It is shown that making use of a single component library to store all kinds of components and from which components are searched is very inefficient. We construct multi-libraries to support software reuse and use PVM as development environments to imitate Iargescale computer, which is expected to fulfill distributed storage and parallel search of components efficiently and improve software reuse.     

高校图书馆人才问题的成因及对策探讨

对目前我国高校图书馆普遍存在的高层次人才短缺，性别比例、年龄、学历和学科知识结构不合理的原因进行了分析，并给出了解决问题的对策。     

新时期创新图书馆管理的若干思考

图书馆创新管理是图书馆可持续发展的动力基础,创新图书馆管理要以人为本,实现人本管理与科学管理,提高馆员的素质,培养创新型的人才.     

清除树脂在组合化学中的应用

清除树脂是一种特殊的固相试剂。近五年，它们被广泛的用于平行液相法合成组合化学库，简化液相组合化学库的纯化操作。本文综述了清除树脂在纯化操作中的使用策略。根据清除纯化原理，介绍了共价键型和离子键型两类清除树脂。给出了清除树脂在组合化学中的具体应用实例。最后对清除树脂的发展作了展望。     

Affinity Chromatography of Insulin with a Heptapeptide Ligand Selected from Phage Display Library

A heptapeptide phage display library was screened with insulin to find its ligands for affinity chromatography. The peptide was synthesized and coupled to EAH Sepharose 4B (5.4 mol mL^–1 bed). Then, insulin chromatography was carried out with mobile phases of different pH values and by the addition of urea and ethylene glycol. It was found that electrostatic interactions were predominant for the affinity binding, and hydrogen bonding might also contribute somewhat to the affinity. Finally, frontal analysis was performed and the dynamic binding capacity of the affinity column for insulin at 50% breakthrough was estimated at 60.6 mg mL^–1 bed, which was about two times higher than the theoretical binding capacity of the monomeric insulin. The result suggests that insulin was bound in dimer state in a stoichiometric relationship with the coupled peptide, indicating the high binding efficiency of the peptide ligand for insulin.     

在肽库中进行小肽筛选的初步研究

以合成六肽ＤＧＧＳＡＡ为模型对在噬菌体肽库中进行小肽筛选做了初步研究。结果表明，含有可形成氢键和离子键残基的小肽能够在噬菌体肽库中进行筛选。并用明显提高了筛选的专一性。     

Application of divergent multi-component reactions in the synthesis of a library of peptidomimetics based on γ-amino-α,β-cyclopropyl acids

The multi-component condensation of organozirconocene, aldimine and zinc carbenoid was applied to the stereoselective synthesis of cyclopropane amino acid derivatives. These compounds served as scaffolds for the preparation of a 46-member library. The C- and N-termini of the cyclopropane amino acid derivatives were diversified by condensations with ten amines and ten acylating agents, respectively. To improve yields and accelerate library synthesis, most products were prepared under microwave irradiation and purified by polymer-bound scavengers and SPE methodology. All compounds were analyzed by LC-MS and a representative selection was fully characterized.