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101.
Toshiki Miyazaki Hyun-Min Kim Tadashi Kokubo Hirofumi Kato Takashi Nakamura 《Journal of Sol-Gel Science and Technology》2001,21(1-2):83-88
Untreated tantalum metal forms bonelike apatite layer on its surface in a simulated body fluid (SBF) after a long period. The apatite formation on the tantalum metal is significantly accelerated, when the metal was previously subjected to NaOH and heat treatments to form an amorphous sodium tantalate on its surface. The fast formation of the apatite on the NaOH- and heat-treated tantalum metal was explained as follows. The sodium tantalate on the surface of the metal releases the Na+ ion via exchange with H3O+ ion in SBF to form a lot of Ta-OH groups on its surface. Thus formed Ta-OH groups induce the apatite nucleation and the released Na+ ion accelerates the apatite nucleation by increasing ionic activity product of the apatite in SBF due to increase in OH– ion concentration. In the present study, in order to confirm this explanation, apatite formations on sodium tantalate gels with different Na/Ta atomic ratios, which were prepared by a sol-gel method were investigated. It was found that even Na2O-free tantalum oxide gel forms the apatite on its surface in SBF. This proves that the Ta-OH groups abundant on the gel can induce the apatite nucleation. The apatite-forming ability of the gels increased with increasing Na/Ta atomic ratios of the gels. The sodium-containing tantalum oxide gels released the Na+ ion, the amount of which increased with increasing Na/Ta atomic ratios of the gels. The released Na+ ion gave an increase in pH of SBF. These results prove that the apatite nucleation induced by the Ta-OH groups is accelerated with the released Na+ ion by increasing ionic activity product of the apatite in SBF. 相似文献
102.
Evaluation of a sensitive HPLC method for the determination of Malondialdehyde, and application of the method to different biological materials 总被引:1,自引:0,他引:1
G. A. Khoschsorur B. M. Winklhofer-Roob H. Rabl Th. Auer Z. Peng R. J. Schaur 《Chromatographia》2000,52(3-4):181-184
Summary Reactive oxygen species (ROS), important mediators of cell and tissue injury during inflammation, are produced by several
types of inflammatory cells. The formation of ROS can be monitored by detection of lipid peroxidation products. The extremely
broad spectrum of biological effects of aldehydic lipid peroxidation products has necessitated the development of a technique
that enables the sensitive routine quantitation of aldehydes formed in biological materials. Malondialdehyde (MDA) is a by-product
of enzymatic eicosanoid formation and an end-product of nonenzymatic peroxidation of polyunsaturated fatty acids with three
or more bisallylic double bonds. The determination of the thiobarbituric acid derivative of MDA (TBA-MDA) is a widely used
method for estimating overall lipid peroxidation. We describe a rapid, isocratic, simple, and sensitive high-performance liquid
chromatographic (HPLC) method with spectrofluorimetric detection for measurement of MDA-TBA in human biological samples such
as plasma, urine, wound secretions, amniotic fluid, sputum and tissue samples. By use of this method, picomole quantities
of MDA can be readily and specifically detected in different biological materials. Coefficients of variation of repeated MDA-TBA
assays were 4.4% within run and 6.9% from run to run. Reference values are given for a variety of human body fluids and for
rat tissues. 相似文献
103.
锂离子选择性微电极在生物体液中的响应 总被引:2,自引:0,他引:2
最近几年已报道了几种锂离子选择性电极.本文作者曾研制了以苯基膦酸二辛酯(DOPP)为溶剂,四苯硼酸盐为活性物质的PVC膜锂离子选择电极.本文在此基础上研制了锂离子选择性微电极,比较了以四苯硼酸钾(KTPB)及四苯硼酸钠(NaTPB)为活性物质的锂微电极的性能.同时考察了微电极在细胞内液、血清及生理盐液中对锂离子的响应特性. 相似文献
104.
Keita Saito Yoshiyuki Tokorodani Chihiro Sakamoto Hiroyuki Kataoka 《Molecules (Basel, Switzerland)》2021,26(19)
The odors and emanations released from the human body can provide important information about the health status of individuals and the presence or absence of diseases. Since these components often emanate from the body surface in very small quantities, a simple sampling and sensitive analytical method is required. In this study, we developed a non-invasive analytical method for the measurement of the body odor component 2-nonenal by headspace solid-phase microextraction coupled with gas chromatography–mass spectrometry by selective ion monitoring. Using a StableFlex PDMS/DVB fiber, 2-nonenal was efficiently extracted and enriched by fiber exposition at 50 °C for 45 min and was separated within 10 min using a DB−1 capillary column. Body odor sample was easily collected by gauze wiping. The limit of detection of 2-nonenal collected in gauze was 22 pg (S/N = 3), and the linearity was obtained in the range of 1–50 ng with a correlation coefficient of 0.991. The method successfully analyzed 2-nonenal in skin emissions and secretions and was applied to the analysis of body odor changes in various lifestyles, including the use of cosmetics, food intake, cigarette smoking, and stress load. 相似文献
105.
We have developed a time-reversible rigid-body (rRB) molecular dynamics algorithm in the isothermal-isobaric (NPT) ensemble. The algorithm is an extension of rigid-body dynamics [Matubayasi and Nakahara, J Chem Phys 1999, 110, 3291] to the NPT ensemble on the basis of non-Hamiltonian statistical mechanics [Martyna, G. J. et al., J Chem Phys 1994, 101, 4177]. A series of MD simulations of water as well as fully hydrated lipid bilayer systems have been undertaken to investigate the accuracy and efficiency of the algorithm. The rRB algorithm was shown to be superior to the state-of-the-art constraint-dynamics algorithm SHAKE/RATTLE/ROLL, with respect to computational efficiency. However, it was revealed that both algorithms produced accurate trajectories of molecules in the NPT as well as NVT ensembles, as long as a reasonably short time step was used. A couple of multiple time-step (MTS) integration schemes were also examined. The advantage of the rRB algorithm for computational efficiency increased when the MD simulation was carried out using MTS on parallel processing computer systems; total computer time for MTS-MD of a lipid bilayer using 64 processors was reduced by about 40% using rRB instead of SHAKE/RATTLE/ROLL. 相似文献
106.
Yongqing Li Jiuchuang Yuan Maodu Chen Fengcai Ma Mengtao Sun 《Journal of computational chemistry》2013,34(19):1686-1696
An accurate single‐sheeted double many‐body expansion potential energy surface is reported for the title system. A switching function formalism has been used to warrant the correct behavior at the and dissociation channels involving nitrogen in the ground and first excited states. The topographical features of the novel global potential energy surface are examined in detail, and found to be in good agreement with those calculated directly from the raw ab initio energies, as well as previous calculations available in the literature. The novel surface can be using to treat well the Renner–Teller degeneracy of the and states of . Such a work can both be recommended for dynamics studies of the reaction and as building blocks for constructing the double many‐body expansion potential energy surface of larger nitrogen/hydrogen‐containing systems. In turn, a test theoretical study of the reaction has been carried out with the method of quantum wave packet on the new potential energy surface. Reaction probabilities, integral cross sections, and differential cross sections have been calculated. Threshold exists because of the energy barrier (68.5 meV) along the minimum energy path. On the curve of reaction probability for total angular momentum J = 0, there are two sharp peaks just above threshold. The value of integral cross section increases quickly from zero to maximum with the increase of collision energy, and then stays stable with small oscillations. The differential cross section result shows that the reaction is a typical forward and backward scatter in agreement with experimental measurement result. © 2013 Wiley Periodicals, Inc. 相似文献
107.
108.
针对金川矿山开采面临的采矿经济与环保压力,利用酒钢低活性酸性矿渣,开展新型充填胶凝材料开发,获得称为固结粉的早强型新型充填胶凝材料。为了实现固结粉在金川矿山工业化应用,针对金川矿山废石、棒磨砂、戈壁砂和河沙等骨料,开展了4种充填骨料的固结粉胶结充填体抗压强度试验。结果表明,除了戈壁粗砂骨料胶结充填体3 d抗压强度小于设计抗压强度外,其他3种充填骨料的固结粉胶结充填体抗压强度均满足金川矿山安全采矿要求,说明早强型固结粉胶凝材料应用于金川矿山充填法采矿中能够替代水泥。 相似文献
109.
The hydrogen bonding pattern in complexes of the type [M2+(H2O)6](dmax)2 (M = Mn, Ni, Co, Zn, Cd, Hdmax = 1,3-dimethyl-8-azaxanthine), [M2+(H2O)4(py)2](dmax)2 (M = Mn, Co, Zn, Cd, py = pyridine) and [M2+(dmax)2(H2O)2(py)2]·2H2O (M = Ni, Cu) were studied by ab initio (MP2/LANL2DZ//B3LYP/LANL2DZ) and density functional theory methods (B3LYP/LANL2DZ, B3LYP/6-31G∗∗ and B3PW91/6-31G∗∗). The investigation includes a variety of theoretical analyses, which include interaction energy, many body analyses, electron density analysis, topological analysis, Mulliken atomic charges, natural atomic charges and harmonic vibrational analysis. The geometrical parameters and vibrational frequencies of dmax (the mono anion of 1,3-dimethyl-8-azaxanthine), [M2+(H2O)6] (M = Mn, Ni, Co, Zn, Cd), [M2+(H2O)4·(py)2] (M = Mn, Co, Zn, Cd) and the complexes, calculated by the theoretical methods, were compared with the recent X-ray crystallographic results and it was observed that the results are found to agree well with the crystallographic results. The present calculations provide an important physicochemical insight into metal cations with 1,3-dimethyl-8-azaxanthine. The results also reveal the active role of coordinated water molecules in modulating the binding of the cation through a specific network of hydrogen bonds. The topology of the motifs generated by these hydrogen bonds has been characterized, adapting to the second coordination sphere concepts usually applied to the first (monodentate, chelate, and bridge) coordination sphere. The optimized structures of the Cd2+, Zn2+ and Cu2+ complexes further interact among themselves in a less tight fashion to generate three dimensional structures (a tape-like hydrogen bond network). Finally these tape-like hydrogen bond network were optimized using the B3LYP/LANL2DZ basis set. 相似文献
110.
Takeshi Yabuta Kanji Tsuru Satoshi Hayakawa Chikara Ohtsuki Akiyoshi Osaka 《Journal of Sol-Gel Science and Technology》2000,19(1-3):745-748
Bioactive organic-inorganic hybrids were synthesized through sol-gel processing starting from -methacryloxypropyltrimethoxysilane. NMR-spectroscopic studies showed the presence of silanol groups (Si–OH) and Si–O–Si bonds. In vitro tests of the hybrids for bioactivity with a simulated body fluid (Kokubo solution) indicated that only calcium-containing hybrids could form apatite on their surfaces. Thus the presence of calcium ions was no less important to deposit apatite than the formation of silanol groups or Si–O–Si bonds. 相似文献