Stochastic resonance is applied to quantitative analysis for weak chromatographic signal of glyburide in plasma

Based on the theory of stochastic resonance, a new method carried on the quantitive analysis to weak chromatographic signal of glyburide in plasma, which was embedded in the noise background and the signal-to-noise ratio (SNR) of HPLC-UV is enhanced remarkably. This method enhances the quantification limit to 1 ng ml⁻¹, which is the same as HPLC-MS, and makes it possible to detect the weak signal accurately by HPLC-UV, which was not suitable before. The results showed good recovery and linear range from 1 to 50 ng ml⁻¹ of glyburide in plasma and the method can be used for quantitative analysis of glyburide.     

Synthesis,characterization, and application of griseofulvin surface molecularly imprinted polymers as the selective solid phase extraction sorbent in rat plasma samples

In present study, an investigation was carried out to develop and validate an analytical method for the selective extraction and determination of griseofulvin (GSF) from plasma samples. For this purpose, a rational approach was made to synthesize and characterize the surface molecularly imprinted polymers (SMIPs). The SMIPs were utilized as solid phase extraction (SPE) sorbents. The SMIPs were prepared by using GSF as template molecule on the surface of modified silica particles through a non-covalent technique. The particles demonstrated high adsorption capacity (119.1 µg/mL), fast adsorption equilibrium time (30 min) and good recognition selectivity for the template drug. The scanning electron microscopy and infrared spectroscopy were used to explain the structural and morphological characteristics of the SMIPs and surface non-imprinted polymers. The SPE method was combined with HPLC for plasma analysis. The method validation results demonstrated that the established method possessed good linearity for GSF ranging from 0.1 to 50 µg/mL (R² = 0.997). The limit of detection for this method was 0.02 µg/mL for rat plasma samples. The recoveries of GSF from spiked plasma samples were (90.7–97.7%) and relative standard deviations were (0.9–4.5%). Moreover, the SMIPs as selective SPE sorbent can be reused more than 8 times which is a clear advantage over commercial SPE sorbents. Finally, the usefulness of the proposed strategy was assessed by extraction and detection of GSF in real rat plasma samples.     

OSC-PLS算法在近红外光谱定量分析中应用的研究

提出一种新的光谱预处理方法--正交信号校正,并将正交信号校正与偏最小二乘法相结合的OSC-PLS方法应用于固体含能材料中挥发份的定量分析.利用正交信号校正,对光谱数据进行预处理,剔除光谱矩阵中所含的各种噪声信号,将去噪后的光谱矩阵作为新的自变量矩阵,再利用偏最小二乘方法建立校正模型.结果表明:用OSC-PLS方法建立模型与用传统偏最小二乘法所建模型相比精度明显提高,这对近红外光谱分析在该领域的应用具有重要的理论意义和实际推广价值.     

基于TMS320C5409的语音处理系统

介绍了一个基于DSP(TMS320C5409)的语音采集、编码、回放系统实例,对于DSP与CODEC芯片如何连接和配合工作提出了较为详细的解决方案,并从硬件、软件两个方面做出了说明.     

G蛋白偶联受体研究进展

G蛋白偶联受体（GPCRs）是体内最大的蛋白质超家族，根据结构的同源性，主要分为A、B、C3族．GPCRs配体的多样性决定配体结合域的多样性．受体分子内相互作用力的破坏、质子化、构象改变、与G蛋白的偶联及受体二聚化参与了GPCRs的活化过程，近年发现GPCRs的失敏和内吞对受体功能调节亦非常重要，本文拟综述以上内容的研究进展．     

微弱信号提取中的小波方法研究

针对于实际应用中的小信号特别是完全被噪声淹没情况下的微弱信号提取的问题，本文依据白噪声信号的小波变换系数相对比有用信号的小波系数小的特点，利用小波变换对信号进行消噪来提取微弱信号，仿真结果表明：小波变换能够有效的消除噪声，将有用微弱信号从受噪声污染的信号中提取出来。     

文化因素的习得在大学英语教学中的作用

大学英语教学中，除掌握良好的语言学习方法外，还应借鉴和吸收英美文化精华。语言与文化的关系非常密切，不同民族的语言反映和记录不同民族特定的文化风貌；不同民族的特定文化，对不同民族的语言的发展，在某种程度、某个层次上起着制约的作用，可以说语言和文化是一个整体。不同民族的文化差异，尤其学生的母语文化对学习目的语的理解和运用有一定的干扰作用，这种负迁移作用在跨文化交际中常常会导致交际双方产生误解和冲突。因此文化因素对培养学生的言语交际能力是必不可少的一环，在教授语言的同时应重视其中所蕴涵的文化因素。     

基于LabVIEW 7．0 Express的测定化学电池E—t关系的虚拟仪器

研制了基于LabVIEW 7．0 Express的实时测定电池电动势(E)与温度(t)关系的化学虚拟仪器系统．运用集成运放器设计制作了电池电动势和温度的调理电路，通过PCI2002卡双通道同时采集，实现了E随t变化关系的跟踪测定，计算机实时绘出E—t曲线．用LabVIEW Function模板中的相关函数编程，剔除野值，获得最佳拟合E—t函数表达式．应用结果表明：该系统操作简单、界面友好，实时数据显示和自动处理数据，避免了人工操作和数据处理的人为误差，结果令人满意．     

基于以太网的数据采集终端设计

具有以太网接口的数据采集终端是以太网数据采集系统的前端设备。采用嵌入式网络单片机来设计以太网接入的数据采集终端,具有结构简单、成本低、体积小、易于实现的特点。主要介绍了以8bit嵌入式网络单片机SF0020为核心,配置512KBytes程序和数据存储空间,通过与A/D转换芯片MAX1263和物理层收发器DM9161的连接,组成一款基于以太网的数据采集终端。它具有250Ksps的最高转换速度,12bit的分辨率和4个输入通道,可以在该数据采集终端基础上,方便地进行网络仪器仪表的开发。     

四台单模激光的混沌强度和位相同步

运用数值模拟的方法对四台空间相互耦合的单模Nd：YAG激光器系统的动力学行为进行了研究，讨论了激光系统中的输出强度，并利用分析信号位相和高斯位相变换对激光系统中强度的位相进行了分析。数值研究表明，激光强度存在混沌同步，且强度的混沌同步是通过其位相同步来实现的。通过对功率谱和李雅普诺夫指数的分析，可以确信所研究的激光系统处于混沌状态。