利用(k,n)-门限方案实现任意访问结构的新方法

使用整数规划，提出了一种利用(k，n)-门限方案实现任意访问结构的新方法．该方法具有如下优点：使用同一个(k，n)-门限方案分享秘密，每个秘密分享的参与者得到子秘密集合的一个子集；秘密分享方案的设计不依赖于特定的(k，n)-门限方案，可以使用任何(k，n)-门限方案实现任意的访问结构；对访问结构没有任何要求(如要求访问结构为图等)；对任意给定的访问结构Γ，该方法所得到的秘密分享方案的(平均)信息率是所有可以使用同一个(k，n)-门限方案实现Γ的秘密分享方案中(平均)信息率最大的．     

卫星构架结构固有频率特性的试验研究和优化设计

以某卫星构架结构为研究对象，在有限元分析和模态试验验证的基础上，建立合理的优化模型，采用序列二次规划法进行固有频率的优化分析，力求尽可能地降低构架结构的总质量，同时保持原有的模态特性基本不变．优化结果表明，减重效果显著，即星上结构部件的减重潜力以及优化设计在工程设计领域的应用具有现实意义．     

钢管订购和运输问题的线性规划模型

本文运用线性规划理论建立了钢管订购和运输计划问题的数学模型。在求解时分别利用了图论中求最短路长的算法、整数规划中的 0— 1规划的解法及运输问题的表上作业法 ,利用计算机求得最优方案 :即最小总费用为 1 2 741 44 .4万元。     

非线性规划理论在裂隙岩体渗流反馈分析中的应用研究

利用实测渗流场资料反求岩体渗流参数是岩体渗流研究的一个方向,但目前在裂隙岩体渗流参数反馈问题方面进展不大,本文把非线性规划理论引入裂隙岩体渗流反馈分析计算中来,通过理论分析和实验验证,寻求到一种有效的适合裂隙岩体渗流运动特点的反馈分析方法,并获得了应用渗流反馈方法的几点指导性的结论。     

一种求解非线性优化问题的可行方向法

针对目前常用的解线性约束的非线性优化问题的方法在实际应用中还存在不收敛、收敛较慢,或"基变量大量达界后,找不到新的入基变量"等问题,该文提出了求解该问题的新方法夹逼可行方向法,已证明算法的最优性与收敛性。指出夹逼可行方向法可视为Frank-Wolfe算法的推广,也可视为是Zoutendijk可行方向法和逐次线性近似方法的改进算法。算例表明,算法收敛速度较Zoutendijk可行方向法、Frank-Wolfe方法等有了较大提高。算法已被研制成实用软件,并成功应用于三峡电力系统优化调度和调峰方式研究中。     

Comparison of Physical Adsorption and Covalent Coupling Methods for Surface Density-Dependent Orientation of Antibody on Silicon

The orientation of antibodies, employed as capture molecules on biosensors, determines biorecognition efficiency and bioassay performance. In a previous publication we demonstrated for antibodies attached covalently to silicon that an increase in their surface amount Γ, evaluated with ellipsometry, induces changes in their orientation, which is traced directly using Time-of-Flight Secondary Ion Mass Spectroscopy combined with Principal Component Analysis. Here, we extend the above studies to antibodies adsorbed physically on a 3-aminopropyltriethoxysilane (APTES) monolayer. Antibodies physisorbed on APTES (0 ≤ Γ ≤ 3.5 mg/m²) reveal the Γ ranges for flat-on, side-on, and vertical orientation consistent with random molecular packing. The relation between orientation and Γ is juxtaposed for silicon functionalized with APTES, APTES modified with glutaraldehyde (APTES/GA) and N-hydroxysuccinimide-silane (NHS-silane). Antibody reorientation occurs at lower Γ values when physisorption (APTES) is involved rather than chemisorption (APTES/GA, NHS-silane). At high Γ values, comparable proportions of molecules adapting head-on and tail-on vertical alignment are concluded for APTES and the NHS-silane monolayer, and they are related to intermolecular dipole–dipole interactions. Intermolecular forces seem to be less decisive than covalent binding for antibodies on the APTES/GA surface, with dominant head-on orientation. Independently, the impact of glutaraldehyde activation of APTES on vertical orientation is confirmed by separate TOF-SIMS measurements.     

基于数学模型的高校学费标准的研究

为制定合理的高等教育学费标准,立足于全国整体水平,以培养质量、家庭满意度、学校满意度和大学性价比为四个目标函数,同时考虑办学成本、家庭负担约束、社会经济和学校财力等作为约束条件,建立多目标规划模型;采用线性加权法将其转化为单目标规划模型,并引入阈值限定进行求解。     

融合图注意力网络和注意力因子分解机的服务推荐方法

为了解决服务推荐过程中的特征稀疏问题、提高服务的语义表示能力,进而提升推荐的准确性和有效性,提出基于图注意力网络(graph attention networks,GAT)研究服务推荐方法,引入服务的组合权重和组合的结构信息,综合利用多种服务特征,提高服务推荐质量。将GAT和注意力因子分解机(attention factorization machine,AFM)结合在一起,利用多头自注意力机制,学习每个节点在图邻域中的重要性;进行信息聚合,处理网络中的不同图结构,以适应服务动态变化的场景。 实验结果显示,在数据平衡的情况下,提出的方法性能表现均好于对比方法;在数据不平衡的情况下,提出的方法大部分性能指标也表现良好,达到了提升服务推荐准确性和有效性的目标。     

Selective lighting up of segments around Gly,Ala and Ser/Thr in proteins

Direct detection of ¹³C nucleus can be used as a valuable alternative where ¹H detection poses a challenge due to relaxation effects, chemical exchange and poor chemical shift dispersion. In this context, we have designed a suite of 2D ¹³C^α‐detected hNCA experiments that provide sequential correlations of ¹³C^α with ¹⁵N on one hand and efficient spectroscopic labeling of certain groups of residues, namely, Gly, Ala, Ser and Thr, on the other. These residues act as checkpoints in the sequential walk, which in turn offer new possibilities of backbone assignment of small proteins from a set of 2D experiments, thereby providing great economy in terms of spectrometer time. The direct identification of peptide segments around Gly, Ala, Ser and Thr residues along a protein chain will be highly valuable for deriving important information on sites of ligand binding, phosphorylation, inhibitor/substrate binding, understanding protein folding pathways, comprehending local conformational dynamics etc. without having to obtain complete sequence‐specific assignments, which can be time consuming and at times formidable, especially in large proteins. We have illustratively demonstrated the multifaceted applications of these variants of 2D experiments on ubiquitin and M‐crystallin. We foresee that these 2D hNCA experiments will provide economic and efficient strategies for studying the structure and function of proteins. Copyright © 2012 John Wiley & Sons, Ltd.     

Geometry of random sequential adsorption

By sequentially adding line segments to a line or disks to a surface at random positions without overlaps, we obtain configurations of the one- and two-dimensional random sequential adsorption (RSA) problem. We have simulated the one- and two-dimensional problem with periodic boundary condition. The one-dimensional simulations are compared with the exact analytical solutions to give an estimate of the accuracy of the simulation. In two dimensions the geometrical properties of the RSA configuration are discussed and in addition known results of the RSA process are reproduced. Various statistical distributions of the Voronoi-Dirichlet (VD) network corresponding to the RSA disk configuration are analyzed. In order to characterize pores in the RSA configuration, we introduce circular holes. There is a direct correspondence between vertices of the VD network and these holes, and also between direct/indirect geometrical neighbors and these holes. The hole size distribution is found to be a parabola. We also find general relations that connect the asymptotic behavior of the surface coverage, the correlation function, and the hole size distribution.