“中国梦”:当代青年价值观重塑的指针

"中国梦"是习近平同志提出的实现我国民族复兴、人民幸福的重要思想。通过对"中国梦"的追求,依靠党的自身建设和"以人为本"的指导原则、强大的"中国精神"和青年人热衷的新媒体平台等手段和方式,重塑当代青年正确的、积极向上的价值观,可以使他们更加清晰地了解和认识"中国梦",并自觉地为实现"中国梦"而努力奋斗。     

Whole wheat flour coating with antioxidant property accelerates tissue remodeling for enhanced wound healing

As a daily food for billions of people for thousands of years,whole grain is rich in phenolic compounds and may have huge potentials to provide natural antioxidants.Herein,owing to the significant biomedical potential,the effect of whole wheat flour solution as antioxidant wound coating for enhanced wound healing has been studied.The results show that the low concentration of whole wheat flour solutions have good biocompatibility and can scavenge radical and intracellular ROS in vitro,accelerating tissue remodeling in vivo to promote wound healing.This kind of whole wheat flour solution has great potential application for cutaneous wound repair.     

急性高血压引起血管重建的数值模拟

通过建立血管重建率方程对急性高血压引起的血管零应力状态重建进行模拟。为体现高血压血管重建在时间和空间上的不均匀性，在重建率方程中引入生长因子，对零应力状态血管的重建进程进行有效控制。以6只正常大鼠腹主动脉的重建为例，对该动脉段由急性高血压引起的重建进行数值模拟。结果表明，所模拟的6只大鼠急性高血压引起的腹主动脉重建都具有相类似的重建趋势和特征，说明所提出的血管重建方法对 急性高血压诱发血管重建的预测具有一定的普遍性。同时，由于在分析模型中引进反映重建非均匀性的生长因子，使得所模拟的重建进程能较好地符合急性高血压血管重建的基本生理病理特征。     

Effects of Bisphenol A and Its Alternatives,Bisphenol F and Tetramethyl Bisphenol F on Osteoclast Differentiation

Bisphenol A (BPA) is a typical environmental endocrine disruptor that exhibits estrogen-mimicking, hormone-like properties and can cause the collapse of bone homeostasis by an imbalance between osteoblasts and osteoclasts. Various BPA substitutes, structurally similar to BPA, have been used to manufacture ‘BPA-free’ products; however, the regulatory role of BPA alternatives in osteoclast differentiation still remains unelucidated. This study aimed to investigate the effects of these chemicals on osteoclast differentiation using the mouse osteoclast precursor cell line RAW 264.7. Results confirmed that both BPA and its alternatives, bisphenol F and tetramethyl bisphenol F (TMBPF), were nontoxic to RAW 264.7 cells. In particular, tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cell staining and activity calculation assays revealed that TMBPF enhanced osteoclast differentiation upon stimulation of the receptor activator of nuclear factor-kappa B ligand (RANKL). Additionally, TMBPF activated the mRNA expression of osteoclast-related target genes, such as the nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1), tartrate-resistant acid phosphatase (TRAP), and cathepsin K (CtsK). Western blotting analysis indicated activation of the mitogen-activated protein kinase signaling pathway, including phosphorylation of c-Jun N-terminal kinase and p38. Together, the results suggest that TMBPF enhances osteoclast differentiation, and it is critical for bone homeostasis and skeletal health.     

On optimal structural remodeling

We present the problem of remodeling a given structure such as to improve structural performance optimally within a specified available resource. The development pertains to all types of problems where the mode of structural response is governed by an extremum principle. A variational formulation is used, and the idea is illustrated for maximum-stiffness remodeling of single-purpose structures.The work of the second author was supported in part by the National Science Foundation.     

给定荷载下的骨骼重建的有限元分析

作为一种活性生物器官 ,骨骼不同部分的密度在给定荷载下要发生变化 ,这种现象叫骨重建。定量的研究骨重建现象是骨生物力学的重要组成部分。在 Cater所做的骨材料的实验基础上 ,骨骼的不同微小部分被简化当作一种各向同性材料。再以有限元分析和迭代计算为手段 ,可以获得一种定量计算骨量的方法。与实验结果对照可以发现 ,此方法可使问题得到解决。     

Progresses in studies of nuclear actin

Actin is a protein abundant in cells. Recently, it has been proved to be universally existent in the nuclei of many cell types. Actin and actin-binding proteins, as well as aetin-related proteins, are necessary for the mediation of the conformation and function of nuclear actin, including the transformation of actin between unpolymerized and polymerized, chromatin remodeling, regulation of gene expression and RNA processing as well as RNA transportation. In this paper, we summarized the progresses in the research of nuclear actin.     

Comparative study of microstructural remodification to porous β-TCP and HA in rabbits

To assess the remolding ability of repaired bone in hydroxyapatite （HA） and β-calcium phosphate （β-TCP） scaffold, two 75% porosity bioceramics with the same three-dimensional geometry were implanted into femoral condyles of rabbits. Histological and micro-computed tomography （micro-CT） results demonstrated abundant new bone formation in the porous HA scaffold along with indistinctive scaffold degradation. Results also indicated that scaffold resorption in the β-TCP group, which was followed by a replacement with newly formed bone, was significantly higher than that in the HA group. The crosslinking trabeculae remodeled from the mixtures of the newly formed bone and β-TCP scaffold remnants might be helpful to promoting even loading and reducing stress. The bone remodeling pattern resulted from bone formation and scaffold resorption was significantly different for the two bioceramics. The results demonstrated that the 75% porous β-TCP was more suitable for new bone remodification than HA scaffold.     

A theory of the adaptive growth of biological materials

Summary In this paper, a new theory of the adaptive growth of biological materials is presented. The theory is derived from the basic laws of continuum mechanics. The material is described as a classical mixture of solid material and fluid. It will be shown that several well-known models of the adaptive growth are embedded in this more general theory. In addition, it is clarified on which material assumptions these models are based. Finally, a solution procedure for the new theory is developed, and several examples are given. Received 31 March 1999; accepted for publication 1 June 1999     

Effects of time delays in a mathematical bone model

In this paper we propose a mathematical model of bone remodeling with time delays of both osteoclast-derived paracrine signaling of tumor and tumor-derived paracrine signaling of osteoclast. The effects of time delays on the growth of tumor cells and bone system are studied in multiple myeloma-induced bone disease. In the case of small osteoclast-derived paracrine signaling, it is found that the growth of tumor cells slows down, the oscillation period of the ratio of osteoclasts to osteoblasts is extended with increasing time delay, and there is a competition between the delay and osteoclast-derived paracrine signaling. In the case of large tumor-derived paracrine signaling, the tumor-derived paracrine signaling can induce a more significant decline in tumor growth for long time delay, and thus slowing down the progression of bone disease. There is an optimal coupling between the tumor-derived paracrine signaling of osteoclasts and time delay during the progressions of bone diseases, which suppresses the tumor growth and the regression of bone disease.