规范高校读者行为杜绝书刊污损现象

介绍了高校图书馆书刊污损的各种现象,分析了书刊污损的原因,提出了杜绝书刊污损的对策。     

论提升高校图书馆馆员与读者双方满意的策略

分析了读者和馆员满意度的现状,提出了提升馆员和读者双方满意度的策略。     

A molecular mechanics approach for analyzing tensile nonlinear deformation behavior of single-walled carbon nanotubes

In this paper, by capturing the atomic information and reflecting the behaviour governed by the nonlinear potential function, an analytical molecular mechanics approach is proposed. A constitutive relation for single-walled carbon nanotubes (SWCNT’s) is established to describe the nonlinear stress-strain curve of SWCNT’s and to predict both the elastic properties and breaking strain of SWCNT’s during tensile deformation. An analysis based on the virtual internal bond (VIB) model proposed by P. Zhang et al. is also presented for comparison. The results indicate that the proposed molecular mechanics approach is indeed an acceptable analytical method for analyzing the mechanical behavior of SWCNT’s. The project supported by the National Natural Science Foundation of China (10121202, 90305015 and 10328203), the Key Grant Project of Chinese Ministry of Education (0306) and the Research Grants Council of the Hong Kong Special Administrative Region, China (HKU 7195/04E).     

Role of Natural Compounds and Target Enzymes in the Treatment of Alzheimer’s Disease

Alzheimer’s disease (AD) is a progressive neurological condition. The rising prevalence of AD necessitates the rapid development of efficient therapy options. Despite substantial study, only a few medications are capable of delaying the disease. Several substances with pharmacological activity, derived from plants, have been shown to have positive benefits for the treatment of AD by targeting various enzymes, such as acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), β-secretase, γ-secretase, and monoamine oxidases (MAOs), which are discussed as potential targets. Medicinal plants have already contributed a number of lead molecules to medicine development, with many of them currently undergoing clinical trials. A variety of medicinal plants have been shown to diminish the degenerative symptoms associated with AD, either in their raw form or as isolated compounds. The aim of this review was to provide a brief summary of AD and its current therapies, followed by a discussion of the natural compounds examined as therapeutic agents and the processes underlying the positive effects, particularly the management of AD.     

两个新的q级数展开式

利用拉马努金西塔函数,建立两个新无穷乘积系数子列的生成函数,并且得到这两个无穷乘积系数的符号是以5为周期的.     

The Relationship between Procyanidin Structure and Their Protective Effect in a Parkinson’s Disease Model

This study evaluated the effect of grape seed-derived monomer, dimeric, and trimeric procyanidins on rat pheochromocytoma cell line (PC12) cells and in a zebrafish Parkinson’s disease (PD) model. PC12 cells were cultured with grape seed-derived procyanidins or deprenyl for 24 h and then exposed to 1.5 mm 1-methyl-4-phenylpyridinium (MPP⁺) for 24 h. Zebrafish larvae (AB strain) 3 days post-fertilization were incubated with deprenyl or grape seed-derived procyanidins in 400 µM 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) for 4 days. The results showed that the procyanidin dimers procyanidin B1 (B1), procyanidin B2 (B2), procyanidin B3 (B3), procyanidin B4 (B4), procyanidin B1-3-O-gallate (B1-G), procyanidin B2-3-O-gallate (B2-G), and the procyanidin trimer procyanidin C1 (C1) had a protective effect on PC12 cells, decreasing the damaged dopaminergic neurons and motor impairment in zebrafish. In PC12 cells and the zebrafish PD model, procyanidin (B1, B2, B3, B4, B1-G, B2-G, C1) treatment decreased the content of reactive oxygen species (ROS) and malondialdehyde (MDA), increased the activity of antioxidant enzymes glutathione peroxidase (GSH-Px), catalase (CAT), and superoxide dismutase (SOD), and upregulated the expression of nuclear factor-erythroid 2-related factor (Nrf2), NAD(P)H: quinone oxidoreductase 1 (NQO1), and heme oxygenase-1 (HO-1). These results suggest that in PC12 cells and the zebrafish PD model, the neuroprotective effects of the procyanidins were positively correlated with their degree of polymerization.     

立体视差调整的快速估计方法

立体图像的视差调整多用于会聚调节和视差校正．为准确地计算出立体图像视差调整量的取值范围,建立了立体视差调整的快速估计方法．算法首先将人类立体视觉的Panum融合区应用于立体显示空间,给出计算立体显示屏幕Panum融合区的方法,然后推导出立体显示屏幕Panum融合区对视差调整量的限定,最后通过对立体图像深度线索的稀疏匹配快速估计出Panum融合区限定下视差调整量的适用范围．经实验验证．本方法可以快速、准确地得到视差调整量的适用范围,最大限度地避免立体图像中出现双眼复视的情况．     

基于模糊综合评价法的大学文科生数学感知程度评价的研究

以大学文科生对数学感知情况的问卷调查为基础,采用模糊综合评价法建立了大学文科生对数学感知情况的评估指标体系和评价方法．首先确定了评估指标体系中各指标的权重,然后建立评价集并构造了模糊评价矩阵,最后模糊合成得到了评价结果．评价结果表明大学文科生对数学的感知情况较好,对数学学习的兴趣程度也较高．根据评价结果提出了大学文科生数学课程的如下建议：一是增加课程的趣味性,穿插一些与文科生相关的数学的小故事;二是多训练学生的逻辑思维和创造性思维,注重教授给学生归纳、类比等数学方法和极限、抽象归纳、规划等数学思想;三是拓宽学生的视野,让学生们了解数学在各个领域内的应用．     

基于NMF技术探寻早期AD基因表达调控网络

利用非负矩阵分解(NMF)技术,依据加强算法的稀疏性对患早期阿尔茨海默症(AD)样本的基因表达数据进行分析,提取对疾病早期诊断具有重要意义的显著基因,样本分类实验结果证明了算法的有效性.在此基础上,结合与炎症反应有重要关系的NF-κB等基因初步建立了与早期AD密切相关的基因表达调控网络结构图,为AD致病机理的探询、早期诊断与治疗等提供了有益的途径和方法.