新型酶响应型水凝胶合成及其在预防三阴性乳腺癌术后复发研究

应用溶剂—反溶剂法制备舒尼替尼纳米粒,通过迈克尔加成反应将药物装载入水凝胶,即合成新型酶响应型舒尼替尼纳米粒水凝胶;通过扫描电镜、粒径分析、药物溶出率计算等方法对新材料进行鉴定和表征;进一步体内外功能试验评估该材料的抗肿瘤及防复发作用;最后对该材料进行初步安全性评价。实验结果表明,实现了酶响应型舒尼替尼纳米粒水凝胶的成功制备,舒尼替尼纳米粒在水凝胶中分布均匀,粒径约400 nm,稳定性能良好;新材料表现出优异的控缓释作用,在体外抑制肿瘤细胞及血管内皮细胞活性,在体内促进小鼠肿瘤细胞凋亡、阻抑肿瘤复发;局部给药过程中,小鼠耐受性良好,新材料无明显毒副作用。     

Pain Management and Analgesics Used in Small Mammals during Post-Operative Period with an Emphasis on Metamizole (Dipyrone) as an Alternative Medication

Metamizole (dipyrone) is a widely used non-opioid analgesic in both human and animal medicine. Metamizole’s safety has been the topic of numerous opposing debates, given the fact that in certain countries metamizole is frequently used as an over-the-counter (OTC) medicine, while in others it is banned due to the risk of agranulocytosis. Further, small mammals such as rabbits, ferrets, rodents, and hedgehogs have become some of the most common pets present in veterinary practice, and each of these species has specific analgesic needs due to their anatomy and physiology. The key to providing appropriate medical care is in finding a substance that has minimal negative effects. In small mammals, analgesia is an important factor and, it happens frequently that, pain in these patients is not well managed. Post-operative pain management is an important topic in the welfare of animals. The objectives of this review, thus, were to provide a concise overview of analgesics that are used in the treatment of postoperative pain in small mammals (e.g., rabbits and rodents) and to highlight the importance of this product, metamizole, in veterinary medicine, as well as the potential of this substance as an alternative analgesic for the treatment of postoperative pain in small mammals.     

Vocal and Laryngeal Effects of Voiced Tongue Vibration Technique According to Performance Time

Our objective is to study the vocal and laryngeal effect as well as the negative signs and sensations related to the voiced tongue vibration technique (VTVT), regarding the time of performance (from 0 to 7 minutes). Thirty adults (15 men and 15 women) with no vocal complaints nor laryngeal disorders were involved. All subjects underwent laryngostroboscopic and auditory perceptual analysis and answered about the existence of uncomfortable sensations that occurred during the exercise (1, 3, 5, and 7 minutes) and postexercise. For the auditory perceptual analysis, the female group presented better outcomes in the third minute of exercise, whereas in general the male group showed no modification because of performance time. Some men presented a significant change in the parameters involved from the fifth minute on. Men and women showed a gradual increase of undesirable sensations. It is extremely important that the performance time of the VTVT is properly prescribed to provide the expected results, without causing undue injuries to the vocal system. Therefore, we suggest this technique should be recommended for 3 and 5 minutes for women and men, respectively.     

足底反射区按摩法在运动后恢复的作用

足底反射区按摩法是一种安全、简便、经济、无副作用,且有强身防病,自我保健作用,特别是运动后的恢复更是实用方便,产生事半功倍的效果。     

食道癌病人的术前术后护理体会

目的：总结食管癌病人术前、术后护理体会．方法：对199例食管癌患者的术前、术后护理进行回顾总结．结果：术前、术后共护理199例食管癌患者,其中男性186例,女性13例．最小年龄39岁,最大年龄78岁．治愈出院195例,术后并发症死亡4例．结论：食管癌手术的成功取决于4个方面：高超的外科手术,耐心细致的心理护理,术后密切观察胸腔闭式引流情况以及指导患者正确的术后进食．     

可穿戴步态辅助技术在康复养老领域中的应用

 步态作为一种个体的特异性生物学信息,应用于医疗健康、运动表现和生物识别等领域。本文综述了当前的步态检测与分析技术的研究进展,及其在康复养老领域的应用。未来伴随不同疾病队列研究的步态数据累积与疾病预测模型的建立,步态检测评估将在康复养老领域具有更重要的应用价值和广泛的应用前景。关键词步态;可穿戴设备;康复;养老;智慧医疗     

主动康复训练机器人的感知交互与控制策略

 目前中国面临巨大的康复压力和需求,康复训练是目前实现患者功能恢复的主要方式。主动型康复机器人能够引导和鼓励患者积极参与到康复训练过程中,达到更优的长期训练效果。从主动康复训练辅助技术、主动康复训练感知与神经交互技术、主动康复训练交互控制策略、主动康复训练技术发展等方面分析了主动型康复训练的问题,表明以人为核心的结构设计可以促进系统的舒适性、个性化建模和运动意图获取,可以提高人机交互准确性、诱发患者主动参与提高训练过程中神经交互的有效性。关键词康复机器人;主动康复;运动意图;人机交互;神经反馈刺激     

基于人体姿态信息的下肢康复机器人运动控制技术

针对下肢运动功能障碍患者术后康复训练辅助设备的跟随控制问题,本研究提出一种基于人体姿态信息的下肢康复机器人运动控制方法。根据康复机器人的结构特性和功能要求,建立机器人运动数据信息采集系统和下肢康复机器人的运动学模型;构建机器人平台上的人体姿态行为信息采集传感器系统,通过分析位移传感器所采集的数据,得到表征人体姿态行为变化的相关信息,经上位机计算生成康复机器人的期望跟随速度;同时,基于模糊PID控制算法设计了跟随控制器。通过仿真和实验验证该控制算法能够有效减小机器人实时跟踪使用者运动过程中的误差,实现康复机器人对人体运动姿态良好的跟随效果。     

开放复位内固定治疗三踝骨折

目的:探讨开放复位内固定治疗三踝骨折的临床疗效。方法:三踝骨折26例,男15例,女11例,开放复位,外踝用腓骨远端解剖钢板内固定,内踝用空心钉或钢丝张力带内固定,后踝用多枚空心钉或钢板螺钉内固定。结果:全部病例均获随访,时间12～18个月,骨折均愈合,无切口感染及创伤性关节炎、关节畸形等并发症发生。关节功能优18例、良6例、较好2例、差0例。结论:三踝骨折后充分术前准备及精准的开放复位内固定后,再辅以及时有效的功能锻炼,能取得良好的治疗效果。     

A Proposal of a Motion Measurement System to Support Visually Impaired People in Rehabilitation Using Low-Cost Inertial Sensors

The rehabilitation of a visually impaired person (VIP) is a systematic process where the person is provided with tools that allow them to deal with the impairment to achieve personal autonomy and independence, such as training for the use of the long cane as a tool for orientation and mobility (O&M). This process must be trained personally by specialists, leading to a limitation of human, technological and structural resources in some regions, especially those with economical narrow circumstances. A system to obtain information about the motion of the long cane and the leg using low-cost inertial sensors was developed to provide an overview of quantitative parameters such as sweeping coverage and gait analysis, that are currently visually analyzed during rehabilitation. The system was tested with 10 blindfolded volunteers in laboratory conditions following constant contact, two points touch, and three points touch travel techniques. The results indicate that the quantification system is reliable for measuring grip rotation, safety zone, sweeping amplitude and hand position using orientation angles with an accuracy of around 97.62%. However, a new method or an improvement of hardware must be developed to improve gait parameters’ measurements, since the step length measurement presented a mean accuracy of 94.62%. The system requires further development to be used as an aid in the rehabilitation process of the VIP. Now, it is a simple and low-cost technological aid that has the potential to improve the current practice of O&M.