DSA、CTA联合MR影像评估AIS患者脑支循环及预后性关系

探讨数字减影血管成像(DSA)、计算机断层扫描血管成像(CTA)联合磁共振(MR)影像评估急性缺血性卒中(AIS)患者脑支循环及预后性关系。选取60例大脑中动脉M1段急性闭塞所致AIS患者为研究对象,根据DSA、CTA与MR影像对其脑侧支循环评估,比较患者基线资料、结局指标等,并分析预后性。结果发现:基于DSA、CTA与MR影像对AIS患者脑侧支循环评估结果一致性良好;3种影像模式下脑侧支循环良好组与不良组结局资料差异显著(P<0.05);多因素分析显示,FVH-ASPECTS评分、rLMC评分、ASITN/SIR分级量表均为AIS患者神经功能预后的独立影响因素。总之,DSA、CTA、MR影像对AIS患者脑侧支循环评估具有一致性,且FVH-ASPECTS评分、rLMC评分、ASITN/SIR分级量表均为AIS患者神经功能预后的独立影响因素。     

Potential Role of Melatonin as an Adjuvant for Atherosclerotic Carotid Arterial Stenosis

Carotid artery stenosis (CAS) is an atherosclerotic disease characterized by a narrowing of the artery lumen and a high risk of ischemic stroke. Risk factors of atherosclerosis, including smoking, hypertension, hyperglycemia, hyperlipidemia, aging, and disrupted circadian rhythm, may potentiate atherosclerosis in the carotid artery and further reduce the arterial lumen. Ischemic stroke due to severe CAS and cerebral ischemic/reperfusion (I/R) injury after the revascularization of CAS also adversely affect clinical outcomes. Melatonin is a pluripotent agent with potent anti-inflammatory, anti-oxidative, and neuroprotective properties. Although there is a shortage of direct clinical evidence demonstrating the benefits of melatonin in CAS patients, previous studies have shown that melatonin may be beneficial for patients with CAS in terms of reducing endothelial damage, stabilizing arterial plaque, mitigating the harm from CAS-related ischemic stroke and cerebral I/R injury, and alleviating the adverse effects of the related risk factors. Additional pre-clinical and clinical are required to confirm this speculation.     

用于负压下气体分析的气相色谱仪的研制

介绍一种可同时分析负压样品中常量Ｏ２,Ｎ２,ＣＯ和微量ＣＯ２的自制专用气相色谱仪。仪器在 负压下取样,经活塞升压后进样。在流程中样品气同时进入并列的色谱柱,再分别检测。常量组分使用热导池检测,微量组分使用氦离子化检测器检测。ＣＯ２的检测灵敏度为１０＾－６量级。实验表明,仪器结构简单,操作方便稳定性好,适合于负压气样的在线分析,负压气样中全组分的分析方法具有推广价值。     

CD47 in the Brain and Neurodegeneration: An Update on the Role in Neuroinflammatory Pathways

CD47 is a receptor belonging to the immunoglobulin (Ig) superfamily and broadly expressed on cell membranes. Through interactions with ligands such as SIRPα, TSP-1, integrins, and SH2-domain bearing protein tyrosine phosphatase substrate-1 (SHPS-1), CD47 regulates numerous functions like cell adhesion, proliferation, apoptosis, migration, homeostasis, and the immune system. In this aspect, previous research has shown that CD47 modulates phagocytosis via macrophages, the transmigration of neutrophils, and the activation of T-cells, dendritic cells, and B-cells. Moreover, several studies have reported the increased expression of the CD47 receptor in a variety of diseases, including acute lymphoblastic leukemia (ALL), chronic myeloid leukemia, non-Hodgkin’s lymphoma (NHL), multiple myeloma (MM), bladder cancer, acute myeloid leukemia (AML), Gaucher disease, Multiple Sclerosis and stroke among others. The ubiquitous expression of the CD47 cell receptor on most resident cells of the CNS has previously been established through different methodologies. However, there is little information concerning its precise functions in the development of different neurodegenerative pathologies in the CNS. Consequently, further research pertaining to the specific functions and roles of CD47 and SIRP is required prior to its exploitation as a druggable approach for the targeting of various neurodegenerative diseases that affect the human population. The present review attempts to summarize the role of both CD47 and SIRP and their therapeutic potential in neurodegenerative disorders.     

摩擦磨损试验机模拟活塞环-缸套摩擦行为的功能开发

参考活塞环-缸套的实际运行条件,结合SRV-4摩擦磨损试验机自身的性能特点和工作原理,通过开发设计,增加合理的硬件及软件测试条件,实现摩擦磨损试验机模拟活塞环-缸套摩擦行为的功能.系统测试结果表明：功能开发后的摩擦磨损试验机可在较短时间内获得活塞环-缸套摩擦副性能优劣的试验数据,满足快速、直观评价活塞环-缸套的摩擦磨损性能的需要,在活塞环-缸套摩擦副研究中具有重要的应用价值.     

Piston Problems of Two-Dimensional Chaplygin Gas

In this paper, the authors study the piston problem for the unsteady two-dimensional Euler system for a Chaplygin gas. The angle of the piston is allowed to vary in a wide range. The piston can be pushed forward into the static gas, or pulled back from the gas. The global existence of solution to the piston problem with any initial speed is established, and the structures of the global solutions are clearly described. The authors find that for the proceeding piston problem the front shock can be detached, attached or even adhere to the surface of the piston depending on the parameters of the flow and the piston; while for the receding problem the front rarefaction wave is always detached and the concentration will never occur.     

On the optimum design of piston rings

We study a family of control problems that arise in the design of dynamically loaded bearings which have a minimum power loss; in particular, we study the design of piston rings with minimum parasitic power loss.This research was partially supported by NSF Grant No. MCS-77-05624.     

Numerical Modeling of Interior Ballistics Processes in Light Gas Guns

An improved procedure for modeling the operation of a light-gas gun is proposed. The motion of working bodies in both the firing chamber and the light-gas chamber is studied within the framework of the mechanics of heterogeneous media. The problem of barrel heating taking into account its melting and removal of thermal ablation products into the medium inside the bore is solved in a coupled formulation. Heat and mass transfer and friction on the barrel surface are calculated using empirical dependences. The deformable piston is considered compressible and elastoviscoplastic. Allowance is made for the presence of a clearance between the lateral surface of the piston and the barrel bore walls and the associated gas flow between the firing and the light-gas chamber. Calculation results are given.     

等熵轻质活塞风洞中活塞质量对匹配压力振荡的影响

等熵轻质活塞风洞的管道中被压缩的气体是作为实验段的气源，在实验阶段，要求其压力维持恒值，称此压力为匹配压力，这一条件只有在忽略活塞质量的理想情况下才可实现，本文研究在实际情况下，即考虑活塞质量时，质量对匹配压力振荡的影响，从而得出活塞质量的选择范围。     

Inverse Piston Problem for the System of One-Dimensional Isentropic Flow

In this paper, the authors consider the inverse piston problem for the system of one-dimensional isentropic flow and obtain that, under suitable conditions, the piston velocity can be uniquely determined by the initial state of the gas on the right side of the piston and the position of the forward shock.