吡啶二甲酸镓、铟配合物的合成及生物活性

吡啶二甲酸能与过渡、非过渡、镧系和锕系金属离子螯合形成稳定的配合物，而且配位方式不拘一格，既可以是双齿，三齿，也可以是桥式配位。吡啶二甲酸的另一重要意义在于它们的生物活性。由于镓具有抗癌，抗肿瘤的活性，吡啶二甲酸镓配合物可能会是一种非常有潜力的新型药物。基于上述事实，本文合成了六种新型的吡啶二甲酸（2，3-，2，5-，2，6-）镓（Ⅲ）、铟（Ⅲ）配合物，并进一步测试了三种镓配合物的生物活性。     

[α-(2-氧代烷基)-α-(取代苯胺基)甲基苯基]-β-D-吡喃阿洛糖苷的合成及镇静活性研究

以豆腐果苷为原料, 通过Mannich反应与取代苯胺和脂肪酮共合成了七个豆腐果苷衍生物, 均未见文献报道. 其结构经¹H NMR, IR, MS和HRMS确认, 并进行了药理活性筛选. 结果表明, 部分化合物均具有良好的镇静活性. 其中, 化合物2a (200 mg/kg), 2b (200 or 100 mg/kg)和2e (200 mg/kg)与豆腐果苷相比较, 具有更强的疗效.     

pH,Definition and measurement at high temperatures

In this review paper, the NBS scale and its limitations are briefly discussed. The magnitude of liquid junction potentials and some calculated values are presented. The use of a molality scale for hydrogen electrode concentration cells at high temperatures is described, and results from measurements on ionization equilibria are summarized. Use of this scale is also recommended for certain circumstances with cells without liquid junction. As an alternative activity scale, use of the Pitzer ion-interaction treatment for ions is recommended for special cases. Finally, reference data are presented for _±HCl in HCl(aq) to 350°C and (HCl+NaCl)(aq) to 200°C that were derived by use of the Pitzer ion-interaction treatment.Presented at the Second International Symposium on Chemistry in High Temperature Water, Provo, UT, August 1991.     

Thermal Study of the Cr-Mo-O System in Air

The phase diagram of the ternary system Cr-Mo-O in air was established from the results of thermal analysis of mixtures with different initial CrO3 to MoO3 ratios. It was found that MoO3 did not take any chromium oxide into solid solution. The presence of Cr2O3 destabilized MoO3 causing it to decompose to MoO2 in the temperature range 723-958 K depending on the initial Cr/Mo ratio. The decomposition of pure MoO3 MoO2 did not occur in air at any temperature. However, this decomposition took place through the formation of the compound Cr2O3·3MoO3(ss) and its decomposition to Cr2O3·3MoO2(ss). The latter compound has never been reported before and the X-ray data for this compound are given. The previously reported catalytic activity of Cr2O3·3MoO3(ss), at high temperatures, is presumably due to its reduction to Cr2O3·3MoO2(ss). This revised version was published online in July 2006 with corrections to the Cover Date.     

Changes in the physicochemical properties of transferrin upon chemical derivatization with ceramides

The interaction of native and derivatized transferrin with lecithin, cholesterol and their mixtures was studied using monomolecular layers of phospholipids. Moreover, the thermodynamic parameters corresponding to these interactions: the mixing excess free energy, interaction energy, and interaction parameter were also calculated.The ability of these two proteins to insert into monolayers was studied working at constant area.The formation of aggregates or secondary structures in solution was determined by the fluorescence and polarization values of ANS (anilinonaphthalene sulfonate), measured at different protein/ANS relationships.Abbreviations TF Transferrin - DTF derivatized transferrin - PC lecithin - CHOL cholesterol - CER ceramides - ANS anilinonaphthalene sulfonate - TNBS trinitro benzenesulfonate method     

Structure-Activity Relationship of Insecticidal Steroids. III. Δ4,7-6-Ketosteroids

The toxicity of steroids 1-11 for colorado beetle (Leptinotarsa decemlineata Say.) larvae was studied by contact-intestinal treatment. Active insect-growth regulators were found among the studied compounds.     

Vapor pressure,speciation, and chemical activities in highly concentrated sodium borate solutions at 277 and 317°C

The system H₂O-B₂O₃-Na₂O has been studied experimentally at 277 and 317°C. The activities of water and boric acid have been determined at mole ratios Na/B from 0 to 1.5, and total dissolved solids 3 to 80 weight percent. The activity of boric acid has been fitted to within experimental error using a speciation model with eight complex species. This model is consistent with the model previously published by Mesmer et al. The electrolyte properties of the liquid are modeled using the Pitzer-Simonson model of very concentrated electrolyte solutions. The calculated values of water activity agree with experiment, and the activity of NaOH and pOH have also been calculated. The potassium borate system also was briefly studied at 317°C, and is adequately described by a model with five complex species. The potassium borate liquid is more alkaline at K/B= 1 than a sodium borate liquid at the same mole ratio, but pOH in the two systems is the same at lower mole ratios.     

含噻二唑环苯甲酰脲化合物的合成及杀虫活性

用活性亚结构连接法设计合成了6个新的含1，3，4-噻二唑杂环苯甲酰脲类化合物，其结构经红外光谱、核磁氢谱、元素分析方法确证。同时对其杀虫活性进行了初步研究，发现该类化合物在普筛浓度下对淡色库蚊幼虫具有较好的杀虫活性。化合物Ⅲb(R1=Cl,R2=n-C5H11),Ⅲd(R1=CH3,R2=n-C5H11),Ⅲf(R1=2,6-difluoro,R2=-C5H11)在10mg/L浓度下对淡色库蚊幼虫的杀虫死亡率大于90％。     

Preparation and characterization of nitrogen-doped TiO2 photocatalyst in different acid environments

Nitrogen-doped TiO₂ powders were successfully prepared by a wet method, i.e., a micro-emulsion-hydrothermal method, in different acid environments. Several characterization techniques, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and UV-visible diffuse reflectance spectra, were combined to determine the crystal phase, concentration and chemical states of the nitrogen doped in TiO₂. The high photocatalytic activity of the nitrogen-doped TiO₂ was evaluated through the decomposition of rhodanmine B under visible light irradiation. It was suggested that the doped nitrogen formed oxynitride (NO) and produced impurity states at higher above the valence band of TiO₂. Therefore, the nitrogen doping could enhance the response of photocatalyst to the visible light and improve the photocatalytic activity because of the narrowing of band gap of TiO₂.