排序方式: 共有135条查询结果,搜索用时 16 毫秒
111.
Dipl.‐Phys. Jonathan List Michael Weber Prof. Dr. Friedrich C. Simmel 《Angewandte Chemie (International ed. in English)》2014,53(16):4236-4239
Amphiphilic compounds have a strong tendency to form aggregates in aqueous solutions. It is shown that such aggregation can be utilized to fold cholesterol‐modified, single‐layered DNA origami structures into sandwich‐like bilayer structures, which hide the cholesterol modifications in their interior. The DNA bilayer structures unfold after addition of the surfactant Tween 80, and also in the presence of lipid bilayer membranes, with opening kinetics well described by stretched exponentials. It is also demonstrated that by combination with an appropriate lock and key mechanism, hydrophobic actuation of DNA sandwiches can be made conditional on the presence of an additional molecular input such as a specific DNA sequence. 相似文献
112.
Inside Cover: Photoresponsive DNA Nanocapsule Having an Open/Close System for Capture and Release of Nanomaterials (Chem. Eur. J. 46/2014)
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113.
Gold‐Nanoparticle‐Mediated Jigsaw‐Puzzle‐like Assembly of Supersized Plasmonic DNA Origami
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Guangbao Yao Dr. Jiang Li Dr. Jie Chao Dr. Hao Pei Dr. Huajie Liu Prof. Yun Zhao Dr. Jiye Shi Dr. Qing Huang Prof. Lianhui Wang Prof. Wei Huang Prof. Chunhai Fan 《Angewandte Chemie (International ed. in English)》2015,54(10):2966-2969
DNA origami has rapidly emerged as a powerful and programmable method to construct functional nanostructures. However, the size limitation of approximately 100 nm in classic DNA origami hampers its plasmonic applications. Herein, we report a jigsaw‐puzzle‐like assembly strategy mediated by gold nanoparticles (AuNPs) to break the size limitation of DNA origami. We demonstrated that oligonucleotide‐functionalized AuNPs function as universal joint units for the one‐pot assembly of parent DNA origami of triangular shape to form sub‐microscale super‐origami nanostructures. AuNPs anchored at predefined positions of the super‐origami exhibited strong interparticle plasmonic coupling. This AuNP‐mediated strategy offers new opportunities to drive macroscopic self‐assembly and to fabricate well‐defined nanophotonic materials and devices. 相似文献
114.
针对折纸机构中刚性折纸机构的运动学特性和刚性折叠条件展开分析,提出了折纸机构能折叠不代表一定能够刚性折叠,核心问题是要找到刚性约束;对于多边形折纸机构,其中心的多边形可以视为公共转轴,实现刚性折叠的约束条件即公共转轴连接相邻顶点的两端运动必须协调一致,主要使用了球面几何学、三角函数等数理方法;通过对单顶点四折痕机构的运... 相似文献
115.
Michael W. Grome Dr. Zhao Zhang Dr. Frédéric Pincet Prof. Chenxiang Lin 《Angewandte Chemie (International ed. in English)》2018,57(19):5330-5334
A major goal of nanotechnology and bioengineering is to build artificial nanomachines capable of generating specific membrane curvatures on demand. Inspired by natural membrane‐deforming proteins, we designed DNA‐origami curls that polymerize into nanosprings and show their efficacy in vesicle deformation. DNA‐coated membrane tubules emerge from spherical vesicles when DNA‐origami polymerization or high membrane‐surface coverage occurs. Unlike many previous methods, the DNA self‐assembly‐mediated membrane tubulation eliminates the need for detergents or top‐down manipulation. The DNA‐origami design and deformation conditions have substantial influence on the tubulation efficiency and tube morphology, underscoring the intricate interplay between lipid bilayers and vesicle‐deforming DNA structures. 相似文献
116.
Complexing DNA Origami Frameworks through Sequential Self‐Assembly Based on Directed Docking
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Dr. Yuki Suzuki Prof. Dr. Hiroshi Sugiyama Prof. Dr. Masayuki Endo 《Angewandte Chemie (International ed. in English)》2018,57(24):7061-7065
Ordered DNA origami arrays have the potential to compartmentalize space into distinct periodic domains that can incorporate a variety of nanoscale objects. Herein, we used the cavities of a preassembled 2D DNA origami framework to incorporate square‐shaped DNA origami structures (SQ‐origamis). The framework was self‐assembled on a lipid bilayer membrane from cross‐shaped DNA origami structures (CR‐origamis) and subsequently exposed to the SQ‐origamis. High‐speed AFM revealed the dynamic adsorption/desorption behavior of the SQ‐origamis, which resulted in continuous changing of their arrangements in the framework. These dynamic SQ‐origamis were trapped in the cavities by increasing the Mg2+ concentration or by introducing sticky‐ended cohesions between extended staples, both from the SQ‐ and CR‐origamis, which enabled the directed docking of the SQ‐origamis. Our study offers a platform to create supramolecular structures or systems consisting of multiple DNA origami components. 相似文献
117.
《中国化学》2018,36(9):875-885
In recent years, bio‐nanopore and solid‐state nanopore have been greatly improved for molecule bio‐sensing. Whereas, the development of this scientific field seems to have encountered a bottleneck due to their respective limitations. The small pore size of the former impedes the detection of large single molecule, and the latter is difficult to achieve similar accuracy and functional control. DNA origami plays a novel role to bring more opportunities for the development of nanopore technology since it is relatively easy to synthesize and modify. This review mainly focuses on introducing the DNA origami nanopore fabrication methods, characterization and application. Meanwhile, the challenges in the present DNA origami nanopore research are also discussed. 相似文献
118.
Frontispiece: Bottom‐Up Fabrication of Nanopatterned Polymers on DNA Origami by In Situ Atom‐Transfer Radical Polymerization
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119.
Bottom‐Up Fabrication of Nanopatterned Polymers on DNA Origami by In Situ Atom‐Transfer Radical Polymerization
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Yu Tokura Yanyan Jiang Dr. Alexander Welle Prof. Martina H. Stenzel Katarzyna M. Krzemien Prof. Jens Michaelis Dr. Rüdiger Berger Prof. Christopher Barner‐Kowollik Dr. Yuzhou Wu Prof. Tanja Weil 《Angewandte Chemie (International ed. in English)》2016,55(19):5692-5697
Bottom‐up strategies to fabricate patterned polymers at the nanoscale represent an emerging field in the development of advanced nanodevices, such as biosensors, nanofluidics, and nanophotonics. DNA origami techniques provide access to distinct architectures of various sizes and shapes and present manifold opportunities for functionalization at the nanoscale with the highest precision. Herein, we conduct in situ atom‐transfer radical polymerization (ATRP) on DNA origami, yielding differently nanopatterned polymers of various heights. After cross‐linking, the grafted polymeric nanostructures can even stably exist in solution without the DNA origami template. This straightforward approach allows for the fabrication of patterned polymers with low nanometer resolution, which provides access to unique DNA‐based functional hybrid materials. 相似文献
120.
Jenny Rackwitz Dr. Janina Kopyra Dr. Iwona Dąbkowska Kenny Ebel MiloŠ Lj. Ranković Prof. Dr. Aleksandar R. Milosavljević Prof. Dr. Ilko Bald 《Angewandte Chemie (International ed. in English)》2016,55(35):10248-10252
2‐Fluoroadenine (2FA) is a therapeutic agent, which is suggested for application in cancer radiotherapy. The molecular mechanism of DNA radiation damage can be ascribed to a significant extent to the action of low‐energy (<20 eV) electrons (LEEs), which damage DNA by dissociative electron attachment. LEE induced reactions in 2FA are characterized both isolated in the gas phase and in the condensed phase when it is incorporated into DNA. Information about negative ion resonances and anion‐mediated fragmentation reactions is combined with an absolute quantification of DNA strand breaks in 2FA‐containing oligonucleotides upon irradiation with LEEs. The incorporation of 2FA into DNA results in an enhanced strand breakage. The strand‐break cross sections are clearly energy dependent, whereas the strand‐break enhancements by 2FA at 5.5, 10, and 15 eV are very similar. Thus, 2FA can be considered an effective radiosensitizer operative at a wide range of electron energies. 相似文献