人胶质瘤细胞SWO-3 8神经营养活性物的初步分离

制备了人胶质瘤细胞ＳＷＯ－３８条件培养基（ＳＷＯ－３８ＣＭ）,经超滤浓缩,截留分子量大于１０ｋＤ的ＳＷＯ－３８ＣＭ,并运用快速自动比色微量分析法检测其对体外培养的ＳＤ大鼠小脑皮质神经元的作用,结果表明,分子量大于１０ｋＤ的ＳＷＯ－３８ＣＭ对神经元的作用,与对照组比较有明显的神经营养活性,分子量大于１０ｋＤ的ＳＷＯ－３８ＣＭ经ＳｅｐｈａｃｒｙｌＳ－２００－ＨＲ凝胶层析并结合生物活性鉴定,获得了具有神     

成年小白鼠新生神经元的观察

将 3[H]标记的胸腺嘧啶核苷 (3[H]-thymidine)注入成年小白鼠腹腔 ,大脑中的神经细胞有丝分裂 ,可通过放射自显影在新生神经细胞中以银粒方式显现 3[H]标记 ,在光镜下观察脑切片中的银粒细胞即为新生神经元 .本实验利用放射自显影的方法 ,在成年小白鼠的海马和嗅球区域观察到新生神经元 .     

Parallel Dynamics of Extremely Diluted Symmetric Q-Ising Neural Networks

The parallel dynamics of extremely diluted symmetric Q-Ising neural networks is studied for arbitrary Q using a probabilistic approach. In spite of the extremely diluted architecture the feedback correlations arising from the symmetry prevent a closed-form solution in contrast with the extremely diluted asymmetric model. A recursive scheme is found determining the complete time evolution of the order parameters taking into account all feedback. It is based upon the evolution of the distribution of the local field, as in the fully connected model. As an illustrative example an explicit analysis is carried out for the Q=2 and Q=3 model. These results agree with and extend the partial results existing for Q=2. For Q>2 the analysis is entirely new. Finally, equilibrium fixed-point equations are derived and a capacity-gain function diagram is obtained.     

利用VSV标记具有特定投射的特异类型神经元的精细结构

神经元是构成神经系统的基本单位之一,对其精细形态结构的研究是了解神经网络构筑和信息处理方式的基础,然而目前缺乏能够标记具有特定投射特征的特异类型神经元精细结构的有效方法.在糖蛋白基因缺失的水泡性口炎病毒（VSV）毒株基础上突变其核蛋白,我们获得了重组病毒VSV-△G-NR7A-EGFP,并发现该病毒在一定窗口期内可实现神经元形态的快速高亮度标记;我们进一步在此基础上构建了VSV-△G-EnvA-NR7A-EGFP病毒,并基于特定的转基因动物及辅助病毒rAAV-EF1α-Dio-Bfp-Tva,通过控制注射位点,分别实现了有NAc-LH投射特异性的D2R神经元和VTA-NAc投射特异性的多巴胺神经元的标记,展示了一种可用于稀疏、高亮地标记具有特定投射特征的特异类型神经元精细结构的新方法.     

A New Model of Coupled Hindmarsh-Rose Neurons

A new model of two coupled neurons is presented by the partly di?usive HindmarshRose equations. The solution semi?ow exhibits globally absorbing characteristics. As the main result, the self-synchronization of the coupled neurons at a uniform rate is proved, which can be extended to complex neuronal networks.     

Novel bivalent positive allosteric AMPA receptor modulator of bis-amide series

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非线性类PID神经元网络控制器

研究了基于比例、积分和微分控制分量非线性方法合成的非线性PID智能控制器.该PID控制器将比例、积分和微分控制分量分别用三角函数表示为误差信号的非线性函数,并通过三个独立的非线性函数构造合成PID控制器.通过在线调整三个独立非线性函数的权值系数,使该控制器实现不依赖于非线性对象模型的智能控制.仿真结果表明该控制器具有优异的非线性控制性能.     

Bursting synchronization in non-locally coupled maps

Neuron activity presents two timescales, a fast one related to action-potential spiking, and a slow timescale in which bursting takes place. Bursting activity in neuron ensembles can be synchronized, meaning the adjustment of the bursting phases due to coupling. We investigated bursting synchronization in a non-locally coupled lattice using a two-dimensional map to describe neuron activity. The coupling involves all sites in a lattice, the corresponding strength decreasing with the lattice distance in a power-law fashion. We observed bursting synchronization for wide intervals of the coupling parameters. We also investigated the bursting synchronization of the ensemble with an external time-periodic signal applied to one or more selected neurons.