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Let k be an algebraically closed field and A the polynomial algebra in r variables with coefficients in k. In case the characteristic of k is 2, Carlsson [9] conjectured that for any DG-A-module M of dimension N as a free A-module, if the homology of M is nontrivial and finite dimensional as a k-vector space, then . Here we state a stronger conjecture about varieties of square-zero upper triangular matrices with entries in A. Using stratifications of these varieties via Borel orbits, we show that the stronger conjecture holds when or without any restriction on the characteristic of k. As a consequence, we obtain a new proof for many of the known cases of Carlsson's conjecture and give new results when and . 相似文献
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Cai and Zhang establish separate perturbation bounds for distances with spectral and Frobenius norms (Cai T, Zhang A. Rate‐optimal perturbation bounds for singular subspaces with applications to high‐dimensional statistics. The Annals of Statistics. 2018; Vol. 46, No. 1: 60?89). We extend their theorem to each unitarily invariant norm. It turns out that our estimation is optimal as well. 相似文献
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Yae Eun Chong Manting Chiang Kiran Deshpande Simon Haroutounian Leonid Kagan Jong Bong Lee 《Biomedical chromatography : BMC》2019,33(11)
Ondansetron, a widely used antiemetic agent, is a P‐glycoprotein (P‐gp) substrate and therefore expression of P‐gp at the blood–brain barrier limits its distribution to the central nervous system (CNS), which was observed to be reversed by coadministration with P‐gp inhibitors. Tariquidar is a potent and selective third‐generation P‐gp inhibitor, and coadministration with ondansetron has shown improved ondansetron distribution to the CNS. There is currently no reported bioanalytical method for simultaneously quantifying ondansetron with a third‐generation P‐gp inhibitor. Therefore, we aimed to develop and validate a method for ondansetron and tariquidar in rat and human plasma samples. A full validation was performed for both ondansetron and tariquidar, and sample stability was tested under various storage conditions. To demonstrate its utility, the method was applied to a preclinical pharmacokinetic study following coadministration of ondansetron and tariquidar in rats. The presented method will be valuable in pharmacokinetic studies of ondansetron and tariquidar in which simultaneous determination may be required. In addition, this is the first report of a bioanalytical method validated for quantification of tariquidar in plasma samples. 相似文献
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《International Journal of Solids and Structures》2014,51(15-16):2865-2877
This paper proposes a procedure to deal with n-layered inclusion based composites with imperfect interfaces (which conditions consist of displacement or stress vector jumps) respecting spherical symmetry. For that purpose, “discontinuity matrices” have been introduced. These matrices have been derived for several classical interface-models and an asymptotic method has been used to determine some of them. A self-consistent condition based on a strain-energy equivalence in the case of inclusion-matrix type composite materials is restated for n-layered inclusions with imperfect interfaces and applied to get estimates of such composites materials. The remarkable feature of the presently self consistent approach is that it does not need any tedious algebra providing the attached interface models respect the spherical symmetry. The present Generalized Self Consistent Model (GSCM) is then used to study size effects and mismatch in composites reinforced by coated inclusions. 相似文献