一个与人类待定肿瘤抑制基因同源的水稻基因的分离

从水稻基因文库中筛选到一个与人类待定肿瘤抑制基因QM同源的基因,命名为OSQM2．该基因片断长为3．1kb,编码一个具有184个氨基酸的高度碱性的蛋白质,与其他已知QM基因相比,该基因具有一个非常特殊的启动子,包含许多在植物中已发现的与抗逆有关的顺式作用因子,如：“G盒”,“DRE盒”,“MYC盒”等,故而该基因有可能是一个新的受环境胁迫因子诱导的基因,Southern杂交表明它以单拷贝形式存在于基因组中。     

Stochastic resonance in the growth of a tumor induced by correlated noises

Since half a century ago, nonlinear physics has changed our views of world drastically[1]. People expected to use it to solve the complexity of biology[2,3]. In the past decade, more and more evidence shows that noise plays an impor- tant role in nonlinear systems[4―10], such as noise-induced phase transitions, stochastic resonance (SR) and so on. Especially, SR uncovered a heap of complexities of biol- ogy[11,12]. For many years, the law of tumors growth has been a challenging subject. Sci…     

Functional Imaging of Breast Tissue and Clinical Application

0Introduction Near infrared(NIR)techniquesarebasedonsensitive,quantitativemeasurementsoffunctionalcontrastbe tweenhealthyanddiseasedtissue.Recently,researchersshowgreatinterestinmeasuringfunctionalpropertiesofbreasttis suesuchashemoglobinconcentrationoroxygensaturationbyNIRspectroscopyandNIRimaging[1,2].NIRlightcanpene trateseveralcentimetersintotissuebeforeitisattenuatedbe lowdetection.ThemainintrinsicmechanismsofNIRlightat tenuationintissuearethescatteringduetoindexofrefractionvariatio…     

拟黑多刺蚁对H22荷瘤鼠抑制肿瘤生长的初探

通过建立动物肿瘤模型,采用对比实验法,探讨拟黑多刺蚁对H22荷瘤鼠的抑瘤作用.结果表明:拟黑多刺蚁具有抑制H22肿瘤细胞的作用,并增强荷瘤鼠的免疫功能.     

三端口四态变量CNN原理在肿瘤生长方程中应用

提出了一种在抗癌免疫监视下的肿瘤生长细胞神经网络(GIsAC CNN)模型.用具有3个端口4个态变量CNN的解析判别法研究了GusAC CNN的分歧图.数值模拟了癌细胞扩散和清除过程.研究结果似乎表明:效应细胞对癌细胞的清除起着至关重要作用,细胞组织中存在免疫缺陷,可能导致癌细胞的转移与扩散.     

细胞凋亡与肿瘤治疗

细胞凋亡与许多疾病特别是肿瘤的发生发展有关，许多癌基因与抑癌基因参与细胞凋亡过程。对细胞凋亡以及在肿瘤治疗中的有关系进行了综述。     

卵巢环状小管性索瘤的临床病理分析

对38例（本院2周及国内文献36例）卵巢太小管性索瘤从临床、病理和激素分泌等方面进行分析，年龄4－60岁，平均23岁。主要临床表现为：内分泌功能紊乱（性早熟，月经不规则及绝经后出血）和腹部肿块，仅1例伴有口唇粘膜黑色素沉着－－胃肠道息肉综合征；特征性组织学结构为：单层或复层环状小管，管周有基底膜样结构。此病属于低度恶性肿瘤，并对此病的组织来源进行了讨论。     

中药对肿瘤组织血管生成的影响

恶性肿瘤的无限制侵袭性生长及其转移依赖于血管生成（angiogenesis)抑制血管生成是不同于常规的肿瘤治疗新策略，肿瘤血管生成的过程是个多步骤过程，目前已进入临床的肿瘤血管生成抑制剂有数十种，许多有抗肿瘤活性的中药的有效成分，如：人参皂苷Rg^3、鲨鱼软骨生成抑因子（SCAIF）等可抑制肿瘤血管生成。     

蝙蝠葛碱增强博莱霉素A5对肿瘤细胞的毒性

应用增殖抑制方法发现,无生长抑制作用的0.5mg ·L~(-1)的蝙蝠葛碱(Dau)使博莱霉素A_5单独对小鼠肉瘤S-180V细胞作用的I_(C50)值从2.1mg·L~(-1)降低到1.3mg·L~(-1),无抑制作用的1 mg·L~(-1) Dau使博莱霉素A_5单独对人喉癌HEP2细胞作用的I_(C50) 值从0.33 mg·L~(-1)降低到0.1 mg·L~(-1).克隆形成法证明:无细胞毒性的10 mg·L~(-1)的Dau明显增强博莱霉素A_5对HEP2细胞毒性.TFP法证实,有一定生长抑制作用的Dau对HEP2细胞内活化钙调素有影响.结果表明:蝙蝠葛碱有一定的增强博莱霉素A_5对肿瘤细胞的毒性.     

Role of FGF-2／FGFR signaling pathway in cancer and its signification in breast cancer

Fibroblast growth factor-2 (FGF-2) is a member of a large family of proteins that bind heparin and heparan sulfate and modulate the function of a wide range of cell types. It has been proved that FGF-2 stimulates the growth and development of new blood vessels (angiogenesis) that contribute to the pathogenesis of several diseases (i.e. cancer, atherosclerosis). However, many of the biological activities of FGF-2 have been found to depend on its receptor抯 intrinsic tyrosine kinase activity and second messengers such as the mitogen activated protein kinases. This review will focus on the mechanism of FGF-2/FGFR induced signaling pathway in tumor and human breast cancer.