随机变量变换分布的若干推论及应用

给出了随机变量变换分布的三个推论，这些推论提供了在不同变换下求二维随机变量的函数的概率密度的计算公式，实例应用表明，这些公式应用简便，灵活，实用．     

The convergence on spectrum of sample covariance matrices for information-plus-noise type data

In this paper,we consider the limiting spectral distribution of the information-plusnoise type sample covariance matrices Cn =1/N (Rn + σXn) (Rn + σXn)*,under the assumption that the entries of Xn are ...     

任意阶光子先增后减和先减后增相干态的非经典性

研究了任意阶的光子先增后减(CA)和光子先减后增(AC)相干态的非经典特性,并给出了相应的解析表达式.AC操作和CA操作由于湮灭算符和产生算符的不对易性,导致产生的两种态具有不同的非经典特性.文中首先给出了两种态的归一化因子的解析表达式,随后在此基础上研究了MandelQ参数、光子数分布和Wigner函数等表征非经典特性的统计量,研究表明两种态都具有非常明显的非经典特性,并且AC操作比CA操作能产生更强的非经典性.     

高压大容量STATCOM主电路的工程选用分析

为了设计出具有高性价比的高压大容量STATCOM装置,从工程设计角度对现有的各种结构的STATCOM主电路进行分析,指出：随着各类工程现场对装置性能要求的不断提高和新的高压大容量功率开关管研制成功,部分STATCOM主电路结构受到限制,甚至遭到淘汰.目前应用和技术上较为先进成熟的两种结构是链式（Cascade）结构和MMC结构.两种结构的稳定性、性价比、损耗节能和技术成熟度等比较分析表明,对于高压大容量STATCOM,链式结构最为适用,应成为设计的首选.MMC结构作为一种先进的结构在模块化程度和器件利用率上具有优势,是未来发展的一个重要方向.     

影响螺纹副轴向力分布均匀性的关键因素分析

通过对螺纹连接结构承载分布问题的理论分析与数值模拟,探索影响螺纹副轴向力分布均匀性的关键因素.首先对螺纹副轴向承载分布进行理论分析,提出依据螺纹副截面上单位长度荷载F与螺纹牙相对变形u的关系曲线确定轴向力分布的解析方法.理论分析表明,当F-u关系曲线呈屈服形状时,螺纹副轴向承载力分布更加均匀.其次,对施必牢螺纹副进行分析,发现其F-u关系曲线呈现出屈服特征;从牙型设计、材料塑性和螺纹错动三方面进行分析,阐明施必牢螺纹副承载分布均匀性好的力学机制;最后,详细分析了螺纹副径向尺寸系数、摩擦因数和材料特性等因素对螺纹上轴向力分布的影响规律.     

Impact of APCI ionization source in liquid chromatography tandem mass spectrometry based tissue distribution studies

Measurement of test article concentration in tissue samples has been an important part of pharmacokinetic study and has helped to co‐relate pharmacokinetic/pharmacodynamic relationships since the 1950s. Bioanalysis of tissue samples using LC–MS/MS comes with unique challenges in terms of sample handling and inconsistent analyte response owing to nonvolatile matrix components. Matrix effect is a phenomenon where the target analyte response is either suppressed or enhanced in the presence of matrix components. Based on previous reports electrospray ionization (ESI) mode of ionization is believed to be more affected by matrix components than atmospheric pressure chemical ionization (APCI) or atmospheric pressure photoionization. To explore the impact of ionization source with respect to bioanalysis of tissue samples, five structurally diverse compounds – atenolol, verapamil, diclofenac, propranolol and flufenamic acid – were selected. Quality control standards were spiked into 10 different biological matrices like whole blood, liver, heart, brain, spleen, kidney, skeletal muscle, eye and skin tissue and were quantified against calibration standards prepared in rat plasma. Quantitative bioanalysis was performed utilizing both APCI and ESI mode and results were compared. Quality control standards when analyzed with APCI mode were found to be more consistent in terms of accuracy and precision as compared with ESI mode. Additionally, for some instances, up to 20‐fold broader dynamic linearity range was observed with APCI mode as compared with ESI mode. As phospholid interferences have poor response in APCI mode, protein precipitation extraction technique can be used for multimatrix quantitation, which is more amenable to automation. The approach of multiple biological matrix quantitation against a single calibration curve helps bioanalysts to reduce turnaround time. Copyright © 2016 John Wiley & Sons, Ltd.     

宽沟矿卸压冲击煤层综采面矿压显现规律

中国煤炭开采规模的不断增大和深化,煤矿冲击地压发生的情况也复杂多变,致灾影响因素众多。目前冲击地压灾害仍然是困扰煤矿安全生产的主要灾害之一。根据新疆准南煤田宽沟煤矿条件,采用系统的矿压观测手段,结合工作面煤柱观测和液压支架工况研究,分析了冲击煤层顶板卸压煤柱应力分布规律,及其对液压支架工作特性的影响,研究揭示了冲击煤层在顶板卸压条件下的综采工作面矿压特点。结果表明,适时进行工作面的顶板水压预裂和爆破切顶处理,对工作面顶板矿压显现控制有重要的作用。研究对类似冲击煤层综采工作面的安全生产具有参考价值。     

A novel liquid chromatography Orbitrap mass spectrometry method with full scan for simultaneous determination of multiple bioactive constituents of Shenkang injection in rat tissues: Application to tissue distribution and pharmacokinetic studies

Shenkang injection is a traditional Chinese formula with good curative effect on chronic renal failure. In this paper, a novel, rapid and sensitive ultra‐high‐performance liquid chromatography coupled with Q Exactive hybrid quadrupole Orbitrap high‐resolution accurate mass spectrometry was developed and validated for simultaneous determination of seven bioactive constituents of Shenkang injection in rat plasma and tissues after intravenous administration. Acetonitrile was used as a protein precipitation agent in biological samples disposal with carbamazepine as internal standard. The chromatographic separation was carried out on a C₁₈ column with a gradient mobile phase consisting of acetonitrile and water (containing 0.1% formic acid). The MS analysis was performed in the full‐scan positive and negative ion mode. The lower limits of quantification for the seven analytes in rat plasma and tissues were 0.1–10 ng/mL. The validated method was successfully applied to tissue distribution and pharmacokinetic studies of Shenkang injection after intravenous administration. The results of the tissue distribution study showed that the high concentrations of seven constituents were primarily in the kidney tract. This is the first report of the application of Q‐Orbitrap with full‐scan mass spectrometry in tissue distribution and pharmacokinetic studies of Shenkang injection.     

Opinion dynamics in networks with heterogeneous confidence and influence

We propose a discrete-time model of opinion dynamics. The neighborhood relationship is decided by confidence radius and influence radius of each agent. We investigate the influence of heterogeneity in confidence/influence distribution on the behavior of the network. The simulations suggest that the heterogeneity of single confidence or influence networks can promote the opinions to achieve consensus. It is shown that the heterogeneous influence radius systems converge in fewer time steps and more often in finite time than the heterogeneous confidence radius systems. We find that heterogeneity does not always promote consensus, and there is an optimal heterogeneity so that the relative size of the largest consensus cluster reaches maximum in heterogeneous confidence and influence networks.     

Simulation of fine polydisperse particle condensational growth under an octadecane–nitrogen atmosphere

The evolution of particle size distribution (PSD) of fine polydisperse particles at high number concentrations (>10⁵ cm⁻³) was simulated through a combined model employing direct quadrature method of moments (DQMOM) with heat and mass transfer equations. The PSD was assumed to retain log-normal distribution during the heterogeneous condensation process. The model was first verified by exact solution and experimental data prior to investigating the influence of initial conditions on final PSD under an octadecane–nitrogen atmosphere. Low particle number concentrations and high vapor concentrations were beneficial to shift the PSD to larger particles having a narrower distribution. Additionally, vapor depletion has more influence on the final PSD than the heat release parameter for a number concentration of 10⁶ cm⁻³. This study may assist the design process of a gas–solid separating cyclone, to eliminate dust from high-temperature volatiles by pyrolysis of solid fuels.