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991.
采用线性扫描伏安法和交流阻抗法研究了碳钢在不同实验条件下的腐蚀规律,碳钢在碳酸铵溶液中的阳极过程为溶解、钝化、过钝化溶解,溶解初期在电极界面的传质为线性扩散控制;随着溶液温度的升高,阻抗谱表示为单一时间常数的容抗弧,容抗弧直径逐渐减小,电阻变小,碳钢的腐蚀速度增大;Cl~-浓度越大,钝化区域变小,碳钢更容易腐蚀;加入硫脲缓蚀剂,碳钢容抗弧直径增大,电阻变大,有利于保护碳钢。 相似文献
992.
Aamer Saeed 《合成通讯》2013,43(9):1485-1490
An efficient microwave‐assisted synthesis of 8‐hydroxy‐6,7‐dimethoxy‐3‐hydroxymethyl isocoumarin (1), a metabolite of Streptomyces mobaraensis and structural relative of reticulol and cytogenin that possesses potent cyclic nucleotide phosphodiesterase inhibitor activity, is described. 3,4,5‐Trimethoxyhomophthalic acid (2) was condensed with acetoxyacetyl chloride under microwave irradiation and the acid hydrolysis of resulting 6,7,8‐trimethoxy‐3‐acetoxymethylisocoumarin (3) afforded the 6,7,8‐trimethoxy‐3‐hydroxymethylisocoumarin (4). Regioselective demethylation of the latter using magnesium iodide in THF yielded the title compound (1). 相似文献
993.
应用自制管道流动安全可视化评价装置模拟液态CO2前置压裂管线或放空阀门附近水合物及干冰生成过程,结合CO2相态预测,明确液态CO2前置压裂地面管线潜在堵塞类型及因素,优选适应液态CO2前置压裂的管线堵塞物抑制剂,并通过数值模拟方法考察地面管线中堵塞物抑制剂驱替液态CO2过程,改进液态CO2前置压裂泵注流程。结果表明:地面管线压力为3.0 MPa时,液态CO2直接放空会在阀门及附近管线中形成干冰;当液态CO2泵注结束后连续注入水基压裂液时,潜在堵塞物为水基压裂液结冰及少量CO2水合物形成的混合物;优选的堵塞物抑制剂冰点低于-30℃,与水基压裂液及液态CO2配伍良好;通过向地面压裂管线泵注0.53 m^3堵塞物抑制剂循环约1 min驱替残余液态CO2,管线温度可迅速恢复至0℃以上;矿场应用表明,一套压裂机组即可实现液态CO2与水基压裂液连续泵注,施工过程未出现管线及阀门堵塞,施工时间由3~4 d缩短至0.5 d,降低了液态CO2前置压裂施工风险。 相似文献
994.
995.
Shenglan Qi Huida Guan Yongli Wang Qinqin Fang Xuemei Cheng Ping Liu Hai Wei Wei Liu Changhong Wang 《Journal of separation science》2023,46(2):2200602
Cordycepin from Cordyceps possesses excellent pharmacological properties, including anti-inflammation and anti-tumor effects, therefore representing a potential alternative medicine. However, doubts about the pharmacokinetic results of cordycepin had been raised in the previous study due to its rapid deamination. The organic solvent methanol was immediately added to terminate the degradation of cordycepin in anticoagulated blood samples and enable the accurate evaluation of pharmacokinetics in vivo. A sensitive and selective ultra-high-performance liquid chromatography coupled with Q Exactive hybrid quadrupole orbitrap high-resolution accurate mass spectrometry method was developed and validated to simultaneously determine cordycepin and its deamination metabolite 3′-deoxyinosine using 2-chloroadenosine as an internal standard in rat whole blood. The calibration curves of cordycepin and 3′-deoxyinosine showed excellent linearity within the concentration range of 1.05–10 000.00 ng/ml with acceptable accuracy, precision, selectivity, recovery, matrix effect, and stability. This method was successfully applied to the pharmacokinetic study of cordycepin and its metabolite in rat blood. The effect of the adenosine deaminase inhibitor erythro-9-(2-hydroxy-3-nonyl) adenine hydrochloride on the pharmacokinetics of cordycepin was investigated. In summary, the reliable pharmacokinetic parameters of cordycepin and its deamination metabolite 3′-deoxyinosine in rat blood were successfully elucidated. Erythro-9-(2-hydroxy-3-nonyl) adenine hydrochloride considerably prolonged the half-life of cordycepin in vivo. 相似文献
996.
Thomas I. Aarhus Vilde Teksum Dr. Anke Unger Dr. Peter Habenberger Dr. Alexander Wolf Dr. Jan Eickhoff Dr. Bert Klebl Dr. Camilla Wolowczyk Prof. Geir Bjørkøy Assoc. Prof. Eirik Sundby Prof. Bård H. Hoff 《European journal of organic chemistry》2023,26(12):e202300052
The colony-stimulating factor 1 receptor (CSF1R) is a protein kinase emerging as an attractive target with clinical relevance in cancer, CNS and inflammatory diseases. Molecular docking experiments followed by synthesis and structure–activity relationship have been used to identify low molecular weight structures as promising hits for lead optimization. These molecules are synthesized from a 4-chloro-6-iodo-pyrrolo[2,3-d]pyrimidine building block using Negishi and Suzuki–Miyaura cross-coupling reactions in high yields. Several inhibitors possessed excellent enzymatic potency, and the parent compound preferably binds to the autoinhibited form of CSF1R. Cellular and in vivo profiling indicate that further tuning of drug structure is needed prior to efficacy studies. 相似文献
997.
Total synthesis of leustroducsin B was achieved via a convergent route, which includes Julia coupling reaction of segment A with segment B followed by Stille coupling reaction of segment C. 相似文献
998.
根据目前铁路煤炭的运输方式,研制了煤炭抑尘剂喷洒适用的设备类型及单位平米的喷洒量,并对其抑尘喷洒量、喷洒作业方式及喷洒效果进行了现场试验。结果表明:摆臂式和龙门式抑尘喷洒设备的抑尘效果较好,通过使用该类设备实现煤炭表面均匀喷洒抑尘剂产品可以有效降低粉尘对环境的污染。 相似文献
999.
几种稀土盐对NH4Cl溶液中锌电极腐蚀的影响 总被引:4,自引:0,他引:4
几种稀土盐对NH4Cl溶液中锌电极腐蚀的影响*张校刚王田芳夏熙**(新疆大学化学系电化学研究室乌鲁木齐830046)关键词无汞Zn/MnO2干电池锌阳极稀土缓蚀剂中图分类号O646.54锌广泛地用作一次和二次电池的阳极材料。但是锌锰电池在搁置期间存在... 相似文献
1000.
Jinyue Su Yatao Qiu Kun Ma Yiwu Yao Zhen Wang Xianling Li Dayong Zhang Zhengchao Tu Sheng Jiang 《Tetrahedron》2014
A new series of largazole analogues in which the side chain was replaced with disulfide groups were synthesized, and their biological activities were evaluated. Compound 8 bearing an octyl moiety showed much better selectivity for HDAC1 over HDAC7 than largazole (320-fold). Structure–activity relationships suggested that the length in the disulfide chain of largazole is important for the selectivity toward HDAC1 over HDAC7. 相似文献