全文获取类型
收费全文 | 3386篇 |
免费 | 111篇 |
国内免费 | 108篇 |
专业分类
化学 | 273篇 |
晶体学 | 3篇 |
力学 | 97篇 |
综合类 | 29篇 |
数学 | 88篇 |
物理学 | 81篇 |
综合类 | 3034篇 |
出版年
2024年 | 21篇 |
2023年 | 33篇 |
2022年 | 43篇 |
2021年 | 61篇 |
2020年 | 61篇 |
2019年 | 50篇 |
2018年 | 47篇 |
2017年 | 54篇 |
2016年 | 58篇 |
2015年 | 63篇 |
2014年 | 137篇 |
2013年 | 136篇 |
2012年 | 161篇 |
2011年 | 200篇 |
2010年 | 190篇 |
2009年 | 198篇 |
2008年 | 229篇 |
2007年 | 268篇 |
2006年 | 197篇 |
2005年 | 235篇 |
2004年 | 187篇 |
2003年 | 182篇 |
2002年 | 157篇 |
2001年 | 143篇 |
2000年 | 111篇 |
1999年 | 74篇 |
1998年 | 49篇 |
1997年 | 50篇 |
1996年 | 38篇 |
1995年 | 34篇 |
1994年 | 39篇 |
1993年 | 23篇 |
1992年 | 14篇 |
1991年 | 16篇 |
1990年 | 16篇 |
1989年 | 13篇 |
1988年 | 8篇 |
1987年 | 4篇 |
1986年 | 2篇 |
1985年 | 2篇 |
1981年 | 1篇 |
排序方式: 共有3605条查询结果,搜索用时 421 毫秒
41.
Bei-sheng Kang Mao-chun Hong Ting-bin Wen Han-qin Liu Jia-xi Lu 《Journal of Cluster Science》1995,6(3):379-401
Simple fragments of transition metal 1,2-bidentate thiolates, the so-called building blocks of the general compositions ML3, ML2, ML, M(O)L2, ML2L, MLL, etc. have been proposed to constitute the di-, tri- and tetranuclear complexes concerned in this review. Structureal regularities and characteristics have been discussed and summarized according to the thiolato ligands edt and pdt, bdt and tdt, mp, and mpo, and mpp, respectively.Abbreviations H2mpo
o-mercaptophenol
- Hmpo
2-mercaptopyridine-N-oxide
- R2dtc
N,N-dialkyldithiocarbamate
- Haet
2-aminoethanethiol
- H2bdt
o-benzenedithiol
- H2pdt
1,2-propanedithiol
- H2tdt
toluene-3,4-dithiol
- Hmpp-mppH
bis-(3-hydroxy-2-pyridyl)disulfide
- Hmp-mpH
bis-(2-oxyphenyl)disulfide
- H2edt
1,2-ethanedithiol
- dppe
1,2-bis(diphenylphosphino)ethane
- H2tedt
3,4,5,6-tetrachlorobenzene-1,2-dithiol
- H2tpdt
3-thiapentane-1,5-dithiol
- H2mnt
maleonitriledithiol
- Him
imidazole
- Bz
benzyl
- py
pyridine 相似文献
42.
Lumbierres M Palomo JM Kragol G Roehrs S Müller O Waldmann H 《Chemistry (Weinheim an der Bergstrasse, Germany)》2005,11(24):7405-7415
A new flexible and efficient methodology for the solid-phase synthesis of lipidated peptides has been developed. The approach is based on the use of previously synthesized building blocks and overcomes the limitations of previously reported methods, since long doubly lipidated peptides can be synthesized by using this route. Furthermore, it was thus possible to prepare a large number of N- and H-Ras peptides bearing a wide range of reporter and/or linking groups--efficient tools for the investigation of biological processes. In terms of efficiency and flexibility this solid-phase method is superior to the solution-phase synthesis. It gives pure peptides in multimilligram amounts within a much shorter time and with superior overall yield. 相似文献
43.
Firoz A. Jaipuri 《Tetrahedron letters》2004,45(21):4149-4152
A versatile route for the modular synthesis of (R)-3-hydroxyalkanoic acids, constituents of the naturally biodegradable poly(3-hydroxyalkanoate) polymers, and its application to the synthesis of (R)-3-hydroxydecanoic acid is described. Key steps include a microwave-assisted catalytic transfer hydrogenation and a facile microwave-assisted hydrolysis of an N-methoxy-N-methyl (Weinreb) amide, which enhances the practicality of this protecting group for carboxylic acids. 相似文献
44.
Luc M. H. Koymans Nico P. E. Vermeulen Allard Baarslag Gabriëlle M. Donné-Op den Kelder 《Journal of computer-aided molecular design》1993,7(3):281-289
Summary A homology model building study of cytochrome P450 2D6 has been carried out based on the crystal structure of cytochrome P450 101. The primary sequences of P450 101 and P450 2D6 were aligned by making use of an automated alignment procedure. This alignment was adjusted manually by matching -helices (C, D, G, I, J, K and L) and -sheets (3/4) of P450 101 that are proposed to be conserved in membrane-bound P450s (Ouzounis and Melvin [Eur. J. Biochem., 198 (1991) 307]) to the corresponding regions in the primary amino acid sequence of P450 2D6. Furthermore, -helices B, B and F were found to be conserved in P450 2D6. No significant homology between the remaining regions of P450 101 and P450 2D6 could be found and these regions were therefore deleted. A 3D model of P450 2D6 was constructed by copying the coordinates of the residues from the crystal structure of P450 101 to the corresponding residues in P450 2D6. The regions without a significant homology with P450 101 were not incorporated into the model. After energy-minimization of the resulting 3D model of P450 2D6, possible active site residues were identified by fitting the substrates debrisoquine and dextrometorphan into the proposed active site. Both substrates could be positioned into a planar pocket near the heme region formed by residues Val370, Pro371, Leu372, Trp316, and part of the oxygen binding site of P450 2D6. Furthermore, the carboxylate group of either Asp100 or Asp301 was identified as a possible candidate for the proposed interaction with basic nitrogen atom(s) of the substrates. These findings are in accordance with a recently published predictive model for substrates of P450 2D6 [Koymans et al., Chem. Res. Toxicol., 5 (1992) 211]. 相似文献
45.
含氟β-氨基酸及其衍生物具有特殊的生理活性, 其合成方法的研究近年来受到广泛关注. 以直接氟化法和间接氟化法分类, 概述了含氟β-氨基酸及其衍生物的合成方法及最新研究进展, 对一些已知化合物的生理活性及药用价值作了初步归纳. 相似文献
46.
Structural tuning of coordination polymers by 4-connecting metal node and secondary building process
Due to variation in ligand's conformation, metal node's connecting geometry, and secondary building process by anions, bat-like, dumbell-like, diamondoid, or pillar-layer topologies are achieved. 相似文献
47.
综述了近年来利用一些新型的含氟砌块,通过它们的环加成反应来高效地合成 含氟杂环化合物的研究,其中包括以下两个部分:(1)用1,3—偶极环加成反应合 成五元含氟杂环化合物;(2)用杂原于Diels-Alder反应合成六元含氟杂环化合物. 相似文献
48.
历史人类学的产生及其意义 总被引:2,自引:0,他引:2
廖杨 《文山师范高等专科学校学报》2005,18(1):1-4
历史人类学是在批判人类学的“无时间感”中提出来的。它大体上经过三个主要发展阶段。中国本土人类学的学术渊源虽然有所不同,但并不排斥“历史”视野。历史人类学本质上是历史的批判,但它又拯救了历史。历史人类学产生的意义,不仅在于指出一些主流的历史决定论自身的历史缺陷,而且还体现为人类学的文化论与历史学的过程论的协调 相似文献
49.
对于施工企业执行建造合同准则的思考 总被引:2,自引:0,他引:2
文章从执行建造合同准则给施工企业会计核算带来的影响入手,对施工企业执行建造合同准则面临的困难和应做的准备工作做了阐述,指出执行建造合同准则,一方面可以促使企业改进成本管理水平,另一方面,如果相应制度和措施滞后,也会影响会计信息的准确性。 相似文献
50.
随着智能建筑数量增加和功能提高,智能建筑逐渐走进人们的生活。本文介绍智能建筑的构成和由DS1820构成的单线多点的自动测试系统的硬件结构和软件流程。 相似文献