Keggin Heteropolyacid Catalyzed Synthesis of Isoxazolo[5,4-d]pyrimidine-4,6(5H,7H)-diones at Room Temperature

Isoxazolo[5,4‐d]pyrimidine‐4,6(5H,7H)diones 2a – 2f have been synthesized from the reaction of ethyl 5‐amino‐3‐methyl‐4‐isoxazole carboxylate ( 1 ) with aryl isocyanates in the presence of Keggin heteropolyacid H₃[PW₁₂O₄₀] as a green solid acid catalyst at room temperature in a one‐pot process in good yields.     

Dehydrogenation activity and structure of polyaniline supported heteropolyacid catalysts

Polyaniline(PAN) supported H₆P₂W₁₈O₆₂(PW) , H₃PMo₁₂O₄₀ (PMo) and H₄PMo₁₁VO₄₀(PMoV) catalysts were prepared and their activities for hexanol conversion were tested. IR, XRD, ICP and SEM measurements proved that the heteropolyacids (HPA) could be supported on this type of polymer. The PAN supported HPA catalysts exhibit higher redox activities and low acid-base activities for the hexanol conversion. The redox activities increase with increasing amount of the heteropolyacid. Substitution of Mo ion by V ion results in an increase of redox activities of the catalysts. This revised version was published online in June 2006 with corrections to the Cover Date.     

正己烷在Pt-Ce促进的氧化硅担载的杂多酸金属氧酸盐上的异构化

制备了用于正己烷临氢异构化的氧化硅担载的Keggin型杂多酸和还原态Pt-Ce氧化物催化剂.这些混合氧化物催化剂或单独使用,或与氧化硅担载的杂多酸催化剂一起使用.用X射线衍射、傅里叶变换红外光谱、傅里叶变换拉曼光谱、热重和N2物理吸附等方法表征在氧化、还原态和催化实验后的催化剂状态.本文的目的是在最佳反应条件(反应温度、还原温度和流量等)下,筛选出具有最好异构化收率的催化剂.结果表明,还原氧化物的存在不但有利于消除积炭,而且在反应期间能有效地维持氧化硅担载杂多酸的结构.从这些催化剂样品中,可以找到具有更好异构化活性和选择性的催化剂.     

含钒杂多酸催化发烟硫酸中甲烷液相部分氧化反应

 以H5PV2Mo10O40 为催化剂,在发烟硫酸中进行了甲烷液相部分氧化,考察了催化剂用量、反应温度、反应时间和发烟硫酸浓度等工艺条件对反应收率的影响. 甲烷在反应中首先转化为硫酸甲酯,硫酸甲酯随后水解为甲醇. 对于甲烷液相部分氧化反应,发烟硫酸中游离的SO3是非常重要的影响因素. 在工艺条件为催化剂用量7.0 mmol, 反应温度473 K, 反应压力3.5 MPa, 反应时间3 h和发烟硫酸中SO3含量50%时,甲烷转化率可达48.5%, 目的产物甲醇收率为41.5%.     

硅钨杂多酸与牛血红蛋白相互作用的研究

多金属氧酸盐作为抗艾滋病病毒、抗流感病毒和抗肿瘤的药物,引起了人们对多金属氧酸与蛋白质之间相互作用的极大关注。蛋白质空间结构的任何变化引起的构象变化都意味着蛋白质分子的活性改变,因此,蛋白质与内源性化合物及许多药物分子之间相互作用的研究一直受到人们关注[1￣3]。血红蛋白是动物及人体内执行输氧任务的蛋白质,是生命机体进行各种生理活动的主要承担者。血红蛋白分子中每条α链和β链含有的色氨酸(Trp)残基分别为α-14Trp、β-15Trp、β-37Trp。Alpert[4]等认为位于疏水腔内的β-37Trp是血红蛋白内源荧光的主要来源,同时β…     

分子筛负载HPA/TiO2催化剂的性能

报道了分子筛负载杂多酸和二氧化钛催化剂MS／HPA／TiO2的制备及其对品红溶液降解的效果，系统研究了催化品红溶液降解的优化条件。实验表明，MS／HPA／TiO2具有良好的催化活性且容易回收。当MS：HPA：TiO2=1：10：1，品红的浓度为0．005％（10mL），催化剂的用量为10mg，反应时间为10min，品红的降解率达到96．87％。     

有机合成中杂多酸催化应用研究十九年

简要概括了作民在课题组１９年间有机合成中以杂多酸为催化剂所开展的研究成果，其中包括从Ｃ４混合物中异丁烯选择低聚，低级烯烃与醋酸的直接酯化，由马豆醛制造喃、杂多酸为改性剂的骨架镍和骨架钴上不饱和醛选择加氢制不饱和醇等研究成果，拓宽了杂多酸的催化研究领域。     

One-pot Synthesis of 3-Aminoimidazo[1,2-a]pyridines Catalyzed by Heteropolyacids

Condensation of aldehydes, isonitriles and 2‐aminopyridines in the presence of H₃PMo₁₂O₄₀ affords different derivatives of 3‐aminoimidazo[1,2‐a]pyridine in good to excellent yields.     

Solvent-free synthesis of functionalized pyridine derivatives using Wells-Dawson heteropolyacid as catalyst

Wells-Dawson heteropolyacids (H₆P₂W₁₈O₆₂·24H₂O) were used as catalysts in the Hantzsch-like multicomponent condensation reaction with 3-formylchromones as aldehyde component, a β-ketoester and ammonium acetate, under solvent-free conditions at 80 °C. Although the desired products were obtained, functionalized pyridines were the main reaction product and became the alternative route to dihydropyridine ring formation. Based on the proposed mechanisms for the formation of each of the obtained products, the multicomponent reaction was modified to afford only the functionalized pyridines (60-99%). Our procedure represents a clean alternative for the synthesis of several highly functionalized pyridines.