Fungicidal activity of tributyltin alkylsulfate esters

Tributyltin alkyl sulfate esters, e.g. tributyltin dodecyl sulfate, tributyltin hexadecyl sulfate and tributyltin octadecyl sulfate, were synthesized from the reaction of bis(tributyltin) oxide and appropriate alkyl hydrogen sulfates. The resulting tributyltin alkyl sulfate esters were found to exhibit fungicidal activity on Penicillium, Aspergillus and Syncephalustrum species.     

Surfactant-based extraction methods

This review covers recent developments in surfactant-based extraction methods, with the aim of highlighting some of the most important aspects of micellar systems together with their applications in analysis. It also compares the phase-transfer methodology of different surfactant-based extraction methods (e.g., cloud-point extraction) with coacervative extraction methods using different kinds of surfactant. It includes factors affecting the extraction efficiency of the methods in some recent applications.     

防霉剂2-溴代肉桂醛的合成新工艺研究

研究了以水、水-乙酸混和溶剂,弱碱乙酸钠作为消除剂合成防霉剂2-溴代肉桂醛的新工艺,探讨了合成的最佳工艺条件.实验结果表明,该工艺具有反应条件温和易控制、产率高、成本低、环境污染小的优点,提供的工艺条件更适合于2-溴代肉桂醛的工业规模生产.     

杀菌剂苯醚甲环唑的制备

研究杀菌剂苯醚甲环唑的制备.以2,4-二氯苯乙酮为起始原料,经醚化、溴化、缩酮化、亲核取代4步反应制得苯醚甲环唑.醚化反应采用一步法,酚的成盐与醚化反应同时进行,收率可达93.6%.在醚化产物(Ⅲ)的甲基上进行溴化反应得到溴化产物(Ⅳ),产率89.1%.化合物(Ⅳ)与1,2-丙二醇反应得到缩酮产物(Ⅴ),产率89.6%.化合物(Ⅴ)与1H-1,2,4-三氮唑进行亲核取代反应得到目标产物(Ⅵ),产率69.0%.对各步反应的工艺进行了改进,总收率高达51.6%.     

Structure–Activity relationships of effect of aryltin compounds on Ceratocystis ulmi

The effect of aryltin compounds (Ar₄Sn and Ar₃SnCl) on the growth of Ceratocystis ulmi, the causative agent of Dutch elm disease, was studied in shake culture. In all cases, the triaryltins were more effective than the tetra-aryltins as inhibitors of C. ulmi in vitro. Furthermore, substitution on the phenyl ring at the meta- and para- positions in the triaryltins did not have a major effect on the biocidal activity for the substituted triaryltins. Quantitative structure–activity relationships (QSARs) gave support to the idea that the species responsible for the inhibition of the fungus is the triaryltin cation. The QSARs further suggest that the interaction of the triaryltin cation with the fungal cell wall of C. ulmi is by a non-specific mechanism.     

杀菌剂嘧霉胺盐的合成及毒力测试

目的 探寻新的优良杀菌剂。方法 以嘧霉胺和有生物活性的酸为原料．室温下反应1h。结果 合成了16个有生物活性的嘧霉胺盐，其中15个为首次报道的新化合物，结构组成经元素分析、IR及^1H NMR确证，并测定了它们对4种植物枯萎病菌的室内毒力作用。结论 反应条件温和，产率高，且多数化合物具有较好的抑菌和杀菌作用。     

涂料防霉剂N-(4-溴-2-甲基苯基)氯乙酰胺的合成与应用

以2-甲基苯胺为原料，经氯乙酰化和溴化两步反应合成涂料防霉剂N-(4-溴-2-甲基苯基)氯乙酰胺（BMPCA），总收率达57.3%。并对该防霉剂的应用作了一定的研究，结果表明：其对涂料中几种常见的霉菌具有较好的防治作用。     

Synthesis and crystal structure of <Emphasis Type="Italic">N</Emphasis>-(6methoxylbenzothiazol-2-yl)-1-(4-fluorophenyl)<Emphasis Type="Italic">O</Emphasis>,<Emphasis Type="Italic">O</Emphasis>-dipropyl-<Emphasis Type="Italic">α</Emphasis>-aminophosphonate

Molecular and crystal structure of N-(6-methoxybenzothiazol-2-yl)-1-(4-fluorophenyl)-O,O-dipropyl-α-aminophosphonate, C₂₁H₂₆FN₂O₄PS, have been determined by single-crystal X-ray diffraction study. The title compound is tetragonal, with a = 21.35(3) Å, c = 20.16(5) Å, Z = 16, D _x = 1.308 Mg/m³, μ(MoKα) = 0.247 mm^?1, and space group is I4₁/a. The structure was solved by direct method and refined to a final R = 0.0687 for 2370 reflections with I > 2σ(I). The compound shows a fully delocalized benzothiazole system with a sp² hybridization of the N(2). There is a strong intermolecular hydrogen bond between P=O and NH. The crystal structure is stabilized by a strong intermolecular N–H?sO hydrogen bond.     

10种药剂防治甜瓜霜霉病的效果试验

10种杀菌剂田间实验结果表明,72%禾本克霜WP(1.2g/kg)、64%杀毒钒WP(1.6g/kg)、72%达克宁WP(1.2g/kg)、50%雷多米尔-锰锌WP(0.83g/kg)和53%金雷多米尔-锰锌WG(0.9g/kg)对甜瓜霜霉病都有较好的防治效果,防效分别为87.3%～96.8%、71.3%、～100%、77.8%～91.8%、65.1%～100%、65.1%～89.7%,是当前防治甜瓜霜霉病较好的药剂.     

恶霉灵为活性组分的聚合杀菌剂的合成

由3－羟基－5－甲基异恶唑（恶霉灵）与甲苯1，4－二异氰酸酯合成了3－（ 3′－异氰酸酯基－4′－甲基苯胺基羰基）氧基－5－甲基异恶唑，以苯乙烯－马 来酸酐的交替共聚物为化学载体，经乙二胺搭桥合成了以恶霉灵为活性组分的聚合 杀菌剂。用IR光谱，^1H NMR、质谱和元素分析等表征了化学结构，讨论了影响反 应的因素。