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991.
Feng‐Li He Xudong Deng Ya‐Qing Zhou Tuo‐Di Zhang Ya‐Li Liu Ya‐Jing Ye Da‐Chuan Yin 《先进技术聚合物》2019,30(2):425-434
Wound dressing, which can release anti‐infectives in a controlled way, is taking an important role in the treatment and recovery of the open wound. An adequate release of antibiotics can prevent infections from microorganisms effectively. Among the new candidates of fabricating base materials for wound dressing, electrospinning fiber mats are attracting numerous attentions for their excellent performance in controlled drug delivery. The drug release behavior of electrospinning fiber mats can be tuned by changing the chemical components and the geometric structures of the mats. In this study, fiber mats with different geometric structures, which composed of poly‐ε‐caprolactone (PCL), polyethylene glycol (PEG), and ciprofloxacin (Cip) with different blending ratios, were successfully fabricated by direct‐writing melt electrospinning, and the release behavior of Cip were subsequently investigated in vitro. The results showed that the addition of PEG improved the hydrophilicity of the mats, which in turn affected the manner of drug release. The presence of PEG changed the releasing mechanism from a non‐Fickian diffusion into Fickian diffusion, which indicated that the diffusion of Cip from the composite fiber mats became the main factor of drug release instead of polymer degradation. Besides, with the same composition but different geometric structures, the drug release behavior is of significant difference. Therefore, all the Cip‐loaded composite fiber mats showed antibacterial activities but with different efficiency. In summary, the release of the drug could be controlled by adding PEG and changing the geometric structures according to the different requirement of wound dressings. 相似文献
992.
Jae Sang Lee Byung Ho Shin Byoung Yong Yoo Sun‐Young Nam Miji Lee Juhwan Choi Hansoo Park Young Bin Choy Chan Yeong Heo Won‐Gun Koh 《Macromolecular bioscience》2019,19(12)
The surface of poly(dimethylsiloxane) (PDMS) is grafted with poly(acrylic acid) (PAA) layers via surface‐initiated photopolymerization to suppress the capsular contracture resulting from a foreign body reaction. Owing to the nature of photo‐induced polymerization, various PAA micropatterns can be fabricated using photolithography. Hole and stripe micropatterns ≈100‐µm wide and 3‐µm thick are grafted onto the PDMS surface without delamination. The incorporation of PAA micropatterns provides not only chemical cues by hydrophilic PAA microdomains but also topographical cues by hole or stripe micropatterns. In vitro studies reveal that a PAA‐grafted PDMS surface has a lower proliferation of both macrophages (Raw 264.7) and fibroblasts (NIH 3T3) regardless of the pattern presence. However, PDMS with PAA micropatterns, especially stripe micropatterns, minimizes the aggregation of fibroblasts and their subsequent differentiation into myofibroblasts. An in vivo study also shows that PDMS samples with stripe micropatterns polarized macrophages into anti‐inflammatory M2 macrophages and most effectively inhibits capsular contracture, which is demonstrated by investigation of inflammation score, transforming‐growth‐factor‐β expression, number of macrophages, and myofibroblasts as well as the collagen density and capsule thickness. 相似文献
993.
The security of a multiparty quantum secret sharing protocol [L.F. Han, Y.M. Liu, J. Liu, Z.J. Zhang, Opt. Commun. 281 (2008) 2690] is reexamined. It is shown that any one dishonest participant can obtain all the transmitted secret bits by a special attack, where the controlled-(-iσy) gate is employed to invalidate the role of the random phase shift operation. Furthermore, a possible way to resist this attack is discussed. 相似文献
994.
995.
Direct visualization of the structural defects in two-dimensional (2D) semiconductors at a large scale plays a significant role in understanding their electrical/optical/magnetic properties, but is challenging. Although traditional atomic resolution imaging techniques, such as transmission electron microscopy and scanning tunneling microscopy, can directly image the structural defects, they provide only local-scale information and require complex setups. Here, we develop a simple, non-invasive wet etching method to directly visualize the structural defects in 2D semiconductors at a large scale, including both point defects and grain boundaries. Utilizing this method, we extract successfully the defects density in several different types of monolayer molybdenum disulfide samples, providing key insights into the device functions. Furthermore, the etching method we developed is anisotropic and tunable, opening up opportunities to obtain exotic edge states on demand. 相似文献
996.
以随机微分方程理论为依托,在经典Black-Scholes模型的基础上进行补充,对欧式期权市场中的投资策略进行了研究,给出了满足预算条件的消费行为的参数限定. 相似文献
997.
采用醇盐水解沉淀法制备超细纳米TiO2,平均晶粒尺寸为20 nm.通过X-射线衍射(XRD)和冷场扫描电镜(SEM)对样品的物相结构和形貌进行了表征,利用半导体测试仪Keithley 2400和精密数字电桥TH2828测试了样品在不同湿度环境下的直流伏安特性、交流电容和交流阻抗,分析其湿敏性能并讨论了湿敏机理. 相似文献
998.
投资学课程的时代背景及中国投资学教材的特点决定了投资学课程教学方式的特殊性.构建了一种基于概率测度的因素挖掘法的教学过程设计模式,将课程知识点的难易程度转化为授课时间分配比例,并与学生素质的量化分布一致.投资学课程教学设计案例表明,基于因素挖掘法的课程教学设计效果较传统教学模式有显著性提高. 相似文献
999.
王丰效 《吉林大学学报(理学版)》2019,57(3):487-492
在半群中引入(U,V) 区间值模糊双理想的概念, 并讨论其基本性质. 给出半群的(U,V) 区间值模糊双理想与模糊双理想以及区间值模糊双理想的关系, 证明半群的(U,V) 区间值模糊双理想的交仍然是半群的(U,V) 区间值模糊双理想, 并讨论半群的(U,V) 区间值模糊双理想直积的相关特性. 相似文献
1000.
采用基于高精度电流守恒格式的直接数值模拟方法,对轴向磁场作用下导电流体的湍流Taylor-Couette流动进行计算.在等电势边界条件的同心圆筒中,磁场与感生电流引起的反向周向速度分布、以及其对平均流动的影响被揭示出来.采用两种不同的湍流流场平均方法,将湍流中的全部脉动划分为平均流动(Taylor涡)的贡献和湍流的贡献.通过计算不同磁场强度下的湍动能的分布,对比分析轴向磁场对平均Taylor涡流和湍流两种贡献方式的影响. 相似文献